CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CMfinder(seed)		RSpredict(seed)
MCC	0.363	>	0.187
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081	>	0.229 ± 0.113
Sensitivity	0.184	>	0.067
Positive Predictive Value	0.716	>	0.523
Total TP	317	>	115
Total TN	1070143	<	1070366
Total FP	134	>	131
Total FP CONTRA	6	<	29
Total FP INCONS	120	>	76
Total FP COMP	8	<	26
Total FN	1402	<	1604
P-value	5.1503931209e-08

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Performance plots

Comparison of performance of CMfinder(seed) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and RSpredict(seed)).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	317
Total TN	1070143
Total FP	134
Total FP CONTRA	6
Total FP INCONS	120
Total FP COMP	8
Total FN	1402

Total Scores
MCC	0.363
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081
Sensitivity	0.184
Positive Predictive Value	0.716
Nr of predictions	26

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	115
Total TN	1070366
Total FP	131
Total FP CONTRA	29
Total FP INCONS	76
Total FP COMP	26
Total FN	1604

Total Scores
MCC	0.187
Average MCC ± 95% Confidence Intervals	0.229 ± 0.113
Sensitivity	0.067
Positive Predictive Value	0.523
Nr of predictions	26

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103737	3	0	3	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77418	3	0	3	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36310	5	0	5	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34979	1	0	1	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121764	17	0	7	10	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56279	1	0	1	0	61
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63541	5	0	5	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	1	0	0	1	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70124	4	0	1	3	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72386	7	0	4	3	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	1	0	0	1	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93527	2	0	1	1	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	3	0	0	3	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.71	0.57	0.89	8	937	1	0	1	0	6
PDB_00716	HDV_ribozyme links to Rfam database...	0.59	0.48	0.73	11	2686	4	0	4	0	12
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27026	2	0	2	0	81
PDB_01092	glmS links to Rfam database...	0.48	0.37	0.63	19	10123	13	1	10	2	33
RFA_00632	HDV_ribozyme links to Rfam database...	0.47	0.39	0.58	11	4076	8	3	5	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.62	0.54	0.71	15	3984	6	3	3	0	13
RFA_00769	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	4	2	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1997	9	6	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00779	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00808	RydC links to Rfam database...	0.60	0.50	0.73	8	2005	4	0	3	1	8
RFA_00809	RydC links to Rfam database...	0.37	0.31	0.45	5	2134	7	0	6	1	11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]