CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Carnac(seed)
MCC 0.563 > 0.552
Average MCC ± 95% Confidence Intervals 0.186 ± 0.591 > 0.182 ± 0.580
Sensitivity 0.338 > 0.327
Positive Predictive Value 0.938 > 0.932
Total TP 270 > 261
Total TN 1387498 < 1387506
Total FP 35 = 35
Total FP CONTRA 5 < 6
Total FP INCONS 13 = 13
Total FP COMP 17 > 16
Total FN 529 < 538
P-value 0.0

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Performance plots


  1. Comparison of performance of Carnac(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 270
Total TN 1387498
Total FP 35
Total FP CONTRA 5
Total FP INCONS 13
Total FP COMP 17
Total FN 529
Total Scores
MCC 0.563
Average MCC ± 95% Confidence Intervals 0.186 ± 0.591
Sensitivity 0.338
Positive Predictive Value 0.938
Nr of predictions 4

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00024 0.74 0.59 0.94 270 1085313 35 5 13 17 188
RFA_00599 0.00 0.00 0.00 0 101475 0 0 0 0 111
RFA_00601 0.00 0.00 0.00 0 99235 0 0 0 0 114
RFA_00602 0.00 0.00 0.00 0 101475 0 0 0 0 116

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 261
Total TN 1387506
Total FP 35
Total FP CONTRA 6
Total FP INCONS 13
Total FP COMP 16
Total FN 538
Total Scores
MCC 0.552
Average MCC ± 95% Confidence Intervals 0.182 ± 0.580
Sensitivity 0.327
Positive Predictive Value 0.932
Nr of predictions 4

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00024 0.73 0.57 0.93 261 1085321 35 6 13 16 197
RFA_00599 0.00 0.00 0.00 0 101475 0 0 0 0 111
RFA_00601 0.00 0.00 0.00 0 99235 0 0 0 0 114
RFA_00602 0.00 0.00 0.00 0 101475 0 0 0 0 116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.