CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Carnac(seed)		HotKnots
MCC	0.582	>	0.522
Average MCC ± 95% Confidence Intervals	0.456 ± 0.229	<	0.533 ± 0.255
Sensitivity	0.354	<	0.526
Positive Predictive Value	0.962	>	0.524
Total TP	101	<	150
Total TN	37613	>	37432
Total FP	5	<	146
Total FP CONTRA	3	<	11
Total FP INCONS	1	<	125
Total FP COMP	1	<	10
Total FN	184	>	135
P-value	1.62913390836e-08

Comparison of performance of Carnac(seed) and HotKnots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(seed) and HotKnots).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(seed) and HotKnots).
Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(seed) and HotKnots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(seed) and HotKnots).

Total Scores
MCC	0.582
Average MCC ± 95% Confidence Intervals	0.456 ± 0.229
Sensitivity	0.354
Positive Predictive Value	0.962
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

Total Scores
MCC	0.522
Average MCC ± 95% Confidence Intervals	0.533 ± 0.255
Sensitivity	0.526
Positive Predictive Value	0.524
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2678	24	1	22	1	23
PDB_01092	glmS links to Rfam database...	0.69	0.65	0.74	34	10107	13	0	12	1	18
RFA_00632	HDV_ribozyme links to Rfam database...	0.38	0.39	0.37	11	4065	19	2	17	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00767	Corona_pk3 links to Rfam database...	0.93	1.00	0.86	18	1870	3	3	0	0	0
RFA_00768	Corona_pk3 links to Rfam database...	1.00	1.00	1.00	18	1873	0	0	0	0	0
RFA_00769	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1934	21	0	19	2	18
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1999	20	0	17	3	18
RFA_00773	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1934	22	0	19	3	18
RFA_00779	Corona_pk3 links to Rfam database...	0.87	0.94	0.81	17	1932	4	3	1	0	1
RFA_00808	RydC links to Rfam database...	1.00	1.00	1.00	16	2000	0	0	0	0	0
RFA_00809	RydC links to Rfam database...	0.79	0.81	0.76	13	2128	4	0	4	0	3

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.