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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Afold [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Afold
MCC 0.725 > 0.453
Average MCC ± 95% Confidence Intervals 0.722 ± 0.015 > 0.504 ± 0.020
Sensitivity 0.597 > 0.449
Positive Predictive Value 0.879 > 0.458
Total TP 30594 > 22979
Total TN 108069777 > 108054370
Total FP 6059 < 30435
Total FP CONTRA 710 < 4084
Total FP INCONS 3487 < 23135
Total FP COMP 1862 < 3216
Total FN 20610 < 28225
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Afold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(20) and Afold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Afold).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 30594
Total TN 108069777
Total FP 6059
Total FP CONTRA 710
Total FP INCONS 3487
Total FP COMP 1862
Total FN 20610
Total Scores
MCC 0.725
Average MCC ± 95% Confidence Intervals 0.722 ± 0.015
Sensitivity 0.597
Positive Predictive Value 0.879
Nr of predictions 228

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.56 0.41 0.75 40 47842 13 0 13 0 57
ASE_00005 0.74 0.56 0.97 66 57902 2 0 2 0 51
ASE_00006 0.66 0.49 0.88 46 47534 6 0 6 0 47
ASE_00007 0.84 0.73 0.96 80 59602 3 0 3 0 30
ASE_00012 0.71 0.56 0.90 69 73843 11 2 6 3 54
ASE_00020 0.60 0.41 0.87 52 73860 8 5 3 0 74
ASE_00021 0.55 0.36 0.86 57 104130 12 2 7 3 103
ASE_00028 0.74 0.55 1.00 69 84597 3 0 0 3 57
ASE_00037 0.80 0.65 1.00 71 59269 1 0 0 1 39
ASE_00038 0.76 0.58 1.00 59 53569 0 0 0 0 42
ASE_00040 0.80 0.66 0.97 88 78912 5 0 3 2 45
ASE_00041 0.77 0.66 0.90 71 57551 8 0 8 0 37
ASE_00042 0.60 0.44 0.81 64 90021 15 0 15 0 81
ASE_00044 0.83 0.70 0.99 74 54540 1 0 1 0 31
ASE_00064 0.79 0.65 0.97 58 45391 2 0 2 0 31
ASE_00068 0.59 0.41 0.85 35 37634 6 0 6 0 50
ASE_00074 0.79 0.63 1.00 75 67821 1 0 0 1 44
ASE_00075 0.56 0.35 0.89 57 108747 12 1 6 5 105
ASE_00077 0.78 0.65 0.93 56 45090 4 1 3 0 30
ASE_00078 0.84 0.71 1.00 59 43012 0 0 0 0 24
ASE_00080 0.46 0.32 0.67 39 71573 19 1 18 0 84
ASE_00081 0.77 0.60 0.98 58 49711 1 0 1 0 39
ASE_00082 0.69 0.49 0.98 57 70442 7 0 1 6 59
ASE_00083 0.73 0.55 0.98 60 62420 1 0 1 0 50
ASE_00084 0.77 0.61 0.97 60 53566 2 1 1 0 39
ASE_00087 0.61 0.39 0.97 56 88352 2 0 2 0 88
ASE_00090 0.76 0.58 1.00 59 55552 0 0 0 0 42
ASE_00092 0.71 0.52 0.97 59 63485 2 1 1 0 54
ASE_00104 0.79 0.64 0.97 76 64183 2 0 2 0 43
ASE_00115 0.77 0.60 0.98 61 54553 1 0 1 0 40
ASE_00118 0.68 0.49 0.94 50 60673 4 1 2 1 52
ASE_00119 0.64 0.43 0.96 46 62787 2 1 1 0 62
ASE_00123 0.75 0.60 0.94 51 38449 3 1 2 0 34
ASE_00125 0.71 0.50 1.00 44 39296 0 0 0 0 44
ASE_00126 0.80 0.65 1.00 53 40417 1 0 0 1 29
ASE_00128 0.76 0.58 1.00 58 53243 0 0 0 0 42
ASE_00129 0.75 0.57 1.00 63 62772 0 0 0 0 48
ASE_00131 0.73 0.53 1.00 45 39295 0 0 0 0 40
ASE_00134 0.74 0.61 0.89 58 50338 7 0 7 0 37
ASE_00135 0.58 0.43 0.78 47 63130 13 0 13 0 62
ASE_00136 0.77 0.62 0.95 57 48145 3 0 3 0 35
ASE_00137 0.68 0.51 0.91 50 48461 6 0 5 1 48
ASE_00138 0.82 0.69 0.98 56 40413 1 1 0 0 25
ASE_00140 0.60 0.40 0.91 50 70821 5 3 2 0 75
ASE_00146 0.81 0.68 0.97 84 70789 3 0 3 0 40
ASE_00153 0.34 0.26 0.45 19 57588 23 4 19 0 54
ASE_00163 0.78 0.63 0.97 59 53240 2 1 1 0 34
ASE_00165 0.73 0.54 0.98 55 52919 2 0 1 1 46
ASE_00170 0.75 0.62 0.91 58 48764 6 1 5 0 35
ASE_00171 0.79 0.63 0.98 59 48456 2 0 1 1 35
ASE_00172 0.69 0.51 0.95 54 58939 3 2 1 0 52
ASE_00174 0.60 0.44 0.83 48 61017 10 1 9 0 61
ASE_00175 0.66 0.51 0.86 55 59967 9 1 8 0 52
ASE_00179 0.74 0.60 0.93 50 44199 5 2 2 1 34
ASE_00180 0.74 0.57 0.97 57 51301 2 1 1 0 43
ASE_00181 0.71 0.54 0.93 57 57569 6 1 3 2 49
ASE_00182 0.62 0.41 0.93 56 84195 4 1 3 0 80
ASE_00183 0.70 0.51 0.97 58 61365 2 1 1 0 55
ASE_00185 0.63 0.41 0.96 53 73481 2 1 1 0 75
ASE_00186 0.71 0.55 0.91 73 78923 10 0 7 3 59
ASE_00190 0.75 0.56 1.00 50 45401 2 0 0 2 40
ASE_00197 0.66 0.50 0.87 72 89170 12 0 11 1 73
ASE_00198 0.76 0.60 0.97 61 52587 2 0 2 0 41
ASE_00203 0.76 0.58 0.98 56 46608 1 0 1 0 40
ASE_00212 0.63 0.45 0.88 67 93885 10 0 9 1 81
ASE_00214 0.72 0.54 0.97 56 56222 3 1 1 1 47
ASE_00215 0.56 0.37 0.84 37 48472 7 0 7 0 62
ASE_00216 0.82 0.67 1.00 55 39285 0 0 0 0 27
ASE_00217 0.82 0.69 0.98 62 40407 2 0 1 1 28
ASE_00221 0.84 0.73 0.97 85 64532 3 0 3 0 32
ASE_00228 0.74 0.62 0.88 53 46911 8 3 4 1 33
ASE_00229 0.77 0.60 0.98 52 42433 3 0 1 2 35
ASE_00231 0.64 0.48 0.87 46 47842 7 0 7 0 50
ASE_00232 0.81 0.68 0.97 57 38444 2 2 0 0 27
ASE_00234 0.58 0.42 0.82 54 75400 12 5 7 0 75
ASE_00238 0.55 0.40 0.75 46 64200 15 3 12 0 68
ASE_00241 0.84 0.72 0.97 63 43891 2 0 2 0 24
ASE_00254 0.83 0.70 0.98 57 36798 1 0 1 0 25
ASE_00255 0.57 0.41 0.79 53 74624 14 0 14 0 77
ASE_00257 0.66 0.51 0.86 49 50983 8 2 6 0 48
ASE_00263 0.72 0.53 0.98 63 70436 1 1 0 0 57
ASE_00267 0.82 0.67 1.00 59 45091 1 0 0 1 29
ASE_00270 0.56 0.35 0.90 45 72340 6 0 5 1 83
ASE_00274 0.65 0.47 0.91 48 55558 5 3 2 0 55
ASE_00277 0.62 0.47 0.83 43 48153 9 2 7 0 48
ASE_00279 0.78 0.63 0.96 64 53234 3 0 3 0 37
ASE_00280 0.76 0.59 0.97 58 51943 2 1 1 0 40
ASE_00282 0.71 0.50 1.00 64 77751 0 0 0 0 63
ASE_00283 0.72 0.54 0.97 58 61716 2 0 2 0 49
ASE_00284 0.74 0.56 0.98 60 58250 1 0 1 0 48
ASE_00285 0.73 0.56 0.94 68 68934 4 2 2 0 54
ASE_00286 0.79 0.64 0.98 59 46605 1 0 1 0 33
ASE_00287 0.67 0.53 0.83 55 54880 11 0 11 0 48
ASE_00292 0.80 0.65 0.98 90 81718 3 0 2 1 48
ASE_00294 0.71 0.52 0.96 89 114388 5 0 4 1 82
ASE_00296 0.72 0.57 0.92 82 91717 8 1 6 1 63
ASE_00297 0.59 0.43 0.82 42 52924 9 2 7 0 56
ASE_00298 0.72 0.54 0.97 61 67465 2 1 1 0 52
ASE_00328 0.78 0.62 0.99 69 72701 6 0 1 5 43
ASE_00332 0.71 0.54 0.94 74 81731 5 0 5 0 64
ASE_00340 0.75 0.61 0.93 52 46000 8 0 4 4 33
ASE_00342 0.86 0.75 0.99 86 62394 1 0 1 0 29
ASE_00361 0.65 0.42 1.00 53 75413 0 0 0 0 74
ASE_00362 0.76 0.58 0.98 53 48151 2 0 1 1 38
ASE_00363 0.71 0.56 0.88 53 51300 7 0 7 0 41
ASE_00364 0.69 0.53 0.89 56 54222 7 1 6 0 49
ASE_00366 0.72 0.58 0.89 57 58589 7 1 6 0 41
ASE_00367 0.84 0.71 1.00 61 43010 1 0 0 1 25
ASE_00369 0.77 0.60 0.98 64 55880 1 0 1 0 43
ASE_00370 0.76 0.60 0.96 50 41853 2 0 2 0 34
ASE_00372 0.75 0.57 0.98 57 51945 1 0 1 0 43
ASE_00374 0.81 0.66 1.00 58 44792 0 0 0 0 30
ASE_00376 0.72 0.55 0.94 58 56891 4 0 4 0 47
ASE_00379 0.76 0.61 0.96 54 46000 3 1 1 1 35
ASE_00382 0.85 0.73 0.98 61 41843 2 0 1 1 23
ASE_00383 0.77 0.59 1.00 62 54553 0 0 0 0 43
ASE_00384 0.77 0.62 0.97 57 48457 2 1 1 0 35
ASE_00386 0.74 0.56 0.98 54 50348 1 0 1 0 42
ASE_00387 0.66 0.49 0.88 51 55887 7 0 7 0 53
ASE_00388 0.78 0.62 0.98 55 45697 2 0 1 1 34
ASE_00390 0.77 0.65 0.92 55 42135 5 2 3 0 30
ASE_00393 0.72 0.58 0.90 54 47835 6 0 6 0 39
ASE_00394 0.79 0.63 0.98 59 46911 1 0 1 0 34
ASE_00395 0.76 0.63 0.91 53 41558 5 0 5 0 31
ASE_00396 0.82 0.69 0.98 57 41558 1 0 1 0 26
ASE_00397 0.74 0.54 1.00 57 54558 0 0 0 0 48
ASE_00398 0.71 0.52 0.96 54 55889 2 0 2 0 50
ASE_00400 0.77 0.60 0.98 64 57905 2 0 1 1 42
ASE_00401 0.65 0.44 0.95 56 76969 3 1 2 0 70
ASE_00402 0.79 0.62 1.00 53 42433 0 0 0 0 32
ASE_00403 0.75 0.57 0.98 61 55883 1 0 1 0 46
ASE_00404 0.80 0.66 0.98 56 43014 2 0 1 1 29
ASE_00411 0.65 0.54 0.77 48 49393 14 6 8 0 41
ASE_00413 0.77 0.64 0.93 52 44495 5 3 1 1 29
ASE_00415 0.55 0.39 0.78 40 54895 11 0 11 0 63
ASE_00416 0.73 0.58 0.93 74 77341 6 1 5 0 53
ASE_00419 0.69 0.54 0.88 56 54882 8 3 5 0 47
ASE_00422 0.69 0.56 0.84 53 46908 11 0 10 1 41
ASE_00428 0.76 0.64 0.90 80 76547 9 1 8 0 45
ASE_00430 0.74 0.57 0.96 55 46914 2 0 2 0 42
ASE_00437 0.56 0.46 0.68 62 79310 29 0 29 0 73
ASE_00441 0.62 0.41 0.94 46 64212 4 0 3 1 66
ASE_00448 0.81 0.71 0.94 79 64177 5 0 5 0 33
ASE_00451 0.79 0.66 0.95 82 70790 4 0 4 0 43
CRW_00024 0.91 0.86 0.95 394 1085188 51 6 13 32 64
CRW_00048 0.86 0.80 0.93 374 1170812 45 10 19 16 96
CRW_00054 0.86 0.80 0.93 364 1107423 43 10 19 14 92
CRW_00059 0.85 0.78 0.93 368 1172351 42 9 18 15 105
CRW_00061 0.86 0.80 0.92 380 1181542 47 10 21 16 96
CRW_00068 0.85 0.80 0.91 365 1108906 48 11 23 14 92
CRW_00096 0.86 0.78 0.95 363 1178497 43 4 16 23 102
CRW_00140 0.86 0.80 0.92 372 1135875 46 11 20 15 91
CRW_00141 0.85 0.78 0.93 371 1201625 47 10 19 18 105
CRW_00150 0.86 0.80 0.92 372 1152515 48 10 24 14 94
CRW_00152 0.84 0.77 0.91 364 1180015 52 13 24 15 107
CRW_00166 0.86 0.78 0.94 364 1190809 45 4 19 22 104
CRW_00173 0.80 0.75 0.86 332 1082272 67 11 41 15 113
CRW_00177 0.83 0.75 0.92 356 1178493 48 7 24 17 117
CRW_00196 0.86 0.79 0.94 377 1207832 45 8 18 19 98
CRW_00230 0.86 0.79 0.94 378 1198524 39 8 16 15 100
CRW_00245 0.87 0.81 0.93 367 1105932 46 9 20 17 86
CRW_00248 0.85 0.77 0.92 375 1218735 46 11 20 15 109
CRW_00250 0.84 0.77 0.92 370 1198524 46 11 21 14 108
CRW_00256 0.84 0.77 0.91 360 1192345 51 10 25 16 108
CRW_00270 0.86 0.80 0.92 362 1111893 46 11 20 15 93
CRW_00271 0.84 0.77 0.91 355 1122363 48 8 25 15 107
CRW_00273 0.86 0.79 0.92 354 1085218 46 8 21 17 92
CRW_00275 0.87 0.81 0.93 371 1114870 46 9 21 16 86
CRW_00277 0.85 0.78 0.91 354 1110408 50 12 21 17 99
CRW_00278 0.84 0.78 0.91 351 1129869 54 7 29 18 99
CRW_00279 0.84 0.77 0.92 357 1180030 50 8 21 21 107
CRW_00280 0.84 0.79 0.89 357 1117860 63 9 34 20 96
CRW_00281 0.84 0.77 0.92 357 1144951 49 9 24 16 107
CRW_00284 0.84 0.77 0.91 350 1131377 50 7 26 17 106
CRW_00285 0.83 0.77 0.90 353 1117869 56 11 27 18 105
CRW_00289 0.82 0.75 0.91 356 1189260 53 9 28 16 120
CRW_00298 0.52 0.37 0.72 183 1620647 90 6 64 20 311
CRW_00301 0.47 0.34 0.64 178 1762223 133 11 91 31 341
CRW_00310 0.49 0.37 0.66 192 1805657 126 13 88 25 329
CRW_00326 0.57 0.40 0.80 201 1627859 78 6 44 28 301
CRW_00330 0.51 0.37 0.71 190 1988747 113 10 68 35 327
CRW_00332 0.48 0.34 0.67 161 1769781 123 8 71 44 316
CRW_00333 0.43 0.30 0.61 155 1892229 131 20 81 30 359
CRW_00345 0.51 0.36 0.72 181 1586621 96 8 61 27 317
CRW_00348 0.54 0.40 0.72 200 1615226 107 10 67 30 303
CRW_00358 0.53 0.39 0.73 196 1675098 99 8 63 28 311
CRW_00366 0.52 0.37 0.71 180 1579501 100 8 64 28 302
CRW_00370 0.58 0.41 0.83 208 1640515 64 4 39 21 298
CRW_00371 0.55 0.40 0.75 199 1611646 93 8 57 28 297
CRW_00372 0.50 0.37 0.69 182 1626042 112 11 71 30 316
CRW_00379 0.49 0.33 0.72 176 2126710 109 5 62 42 358
CRW_00386 0.51 0.35 0.73 182 1751006 96 7 61 28 333
CRW_00403 0.52 0.39 0.70 180 1606270 126 11 67 48 284
CRW_00411 0.51 0.38 0.68 189 1615224 117 8 82 27 307
CRW_00414 0.48 0.34 0.67 170 1665972 109 11 72 26 325
CRW_00466 0.86 0.79 0.93 364 1116372 45 9 20 16 94
CRW_00589 0.86 0.78 0.94 347 1094091 45 2 20 23 98
CRW_00590 0.86 0.79 0.93 359 1119369 53 3 25 25 93
CRW_00591 0.86 0.79 0.92 354 1098520 55 6 23 26 92
CRW_00598 0.49 0.34 0.70 169 1665982 103 5 69 29 322
CRW_00758 0.52 0.38 0.72 184 1640510 108 6 66 36 299
CRW_00759 0.51 0.38 0.69 181 1636884 113 8 72 33 300
CRW_00760 0.52 0.37 0.74 180 1638713 102 7 55 40 306
CRW_00772 0.79 0.73 0.85 295 945652 81 5 48 28 109
CRW_00789 0.83 0.76 0.91 340 1137411 63 5 30 28 107
CRW_00795 0.80 0.72 0.88 284 1152598 97 3 36 58 110
CRW_00849 0.82 0.76 0.88 357 1117854 65 10 39 16 113
CRW_01153 0.50 0.36 0.69 179 1606270 108 8 71 29 324
CRW_01171 0.49 0.36 0.67 183 1593733 116 11 78 27 323
CRW_01300 0.55 0.40 0.76 205 1693451 88 6 58 24 310
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00703 0.81 0.70 0.92 348 1073468 55 8 21 26 147
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_00854 0.77 0.65 0.90 348 1500393 73 4 33 36 187
PDB_01088 0.75 0.62 0.90 341 1471090 76 2 37 37 206
PDB_01103 0.77 0.64 0.92 361 1606134 59 8 25 26 201
PDB_01105 0.78 0.66 0.92 359 1433581 59 2 29 28 181
PDB_01120 0.79 0.68 0.92 357 1204739 53 7 25 21 170
PDB_01273 0.80 0.69 0.91 341 1117886 62 6 27 29 150
RFA_00599 0.89 0.83 0.96 92 101379 9 1 3 5 19
RFA_00601 0.90 0.86 0.93 98 99130 13 1 6 6 16
RFA_00602 0.87 0.84 0.91 97 101368 18 1 9 8 19
TMR_00038 0.68 0.56 0.82 62 71177 15 5 9 1 48
TMR_00046 0.53 0.45 0.63 43 62767 26 4 21 1 53
TMR_00048 0.66 0.53 0.82 50 64919 12 7 4 1 45
TMR_00458 0.65 0.54 0.79 50 63483 15 6 7 2 43
TMR_00568 0.77 0.68 0.87 67 60649 15 1 9 5 32

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 22979
Total TN 108054370
Total FP 30435
Total FP CONTRA 4084
Total FP INCONS 23135
Total FP COMP 3216
Total FN 28225
Total Scores
MCC 0.453
Average MCC ± 95% Confidence Intervals 0.504 ± 0.020
Sensitivity 0.449
Positive Predictive Value 0.458
Nr of predictions 228

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.51 0.52 0.51 50 47797 49 10 38 1 47
ASE_00005 0.61 0.56 0.66 66 57870 39 0 34 5 51
ASE_00006 0.66 0.67 0.65 62 47491 36 7 26 3 31
ASE_00007 0.56 0.53 0.59 58 59586 45 1 40 4 52
ASE_00012 0.41 0.39 0.43 48 73808 72 1 63 8 75
ASE_00020 0.57 0.54 0.60 68 73807 46 6 39 1 58
ASE_00021 0.54 0.51 0.59 81 104058 66 7 50 9 79
ASE_00028 0.58 0.56 0.61 70 84551 54 4 41 9 56
ASE_00037 0.34 0.32 0.37 35 59245 63 0 60 3 75
ASE_00038 0.53 0.52 0.54 53 53529 48 4 42 2 48
ASE_00040 0.50 0.47 0.53 63 78883 63 5 52 6 70
ASE_00041 0.53 0.51 0.55 55 57530 51 2 43 6 53
ASE_00042 0.44 0.42 0.47 61 89969 73 3 67 3 84
ASE_00044 0.74 0.70 0.78 74 54520 26 3 18 5 31
ASE_00064 0.43 0.43 0.44 38 45364 54 5 44 5 51
ASE_00068 0.33 0.32 0.36 27 37599 50 2 47 1 58
ASE_00074 0.48 0.47 0.50 56 67784 57 7 49 1 63
ASE_00075 0.65 0.59 0.72 95 108679 46 3 34 9 67
ASE_00077 0.52 0.51 0.54 44 45068 39 6 32 1 42
ASE_00078 0.67 0.67 0.67 56 42988 32 5 22 5 27
ASE_00080 0.50 0.48 0.52 59 71518 59 3 51 5 64
ASE_00081 0.46 0.45 0.46 44 49675 53 5 46 2 53
ASE_00082 0.57 0.54 0.61 63 70396 51 1 40 10 53
ASE_00083 0.71 0.67 0.76 74 62383 32 1 23 8 36
ASE_00084 0.72 0.71 0.73 70 53532 30 6 20 4 29
ASE_00087 0.56 0.51 0.61 74 88288 54 5 43 6 70
ASE_00090 0.46 0.47 0.47 47 55510 59 6 48 5 54
ASE_00092 0.68 0.65 0.72 73 63444 35 3 26 6 40
ASE_00104 0.53 0.50 0.56 60 64153 49 8 40 1 59
ASE_00115 0.55 0.54 0.56 55 54517 51 1 42 8 46
ASE_00118 0.38 0.38 0.39 39 60625 64 5 57 2 63
ASE_00119 0.63 0.60 0.67 65 62738 35 1 31 3 43
ASE_00123 0.44 0.42 0.46 36 38425 48 3 39 6 49
ASE_00125 0.64 0.63 0.65 55 39255 32 4 26 2 33
ASE_00126 0.74 0.74 0.73 61 40387 27 3 19 5 21
ASE_00128 0.74 0.72 0.77 72 53207 30 2 20 8 28
ASE_00129 0.77 0.74 0.80 82 62732 26 3 18 5 29
ASE_00131 0.62 0.55 0.70 47 39273 31 0 20 11 38
ASE_00134 0.43 0.42 0.44 40 50313 54 7 43 4 55
ASE_00135 0.45 0.44 0.45 48 63084 63 8 50 5 61
ASE_00136 0.69 0.65 0.72 60 48122 28 3 20 5 32
ASE_00137 0.44 0.43 0.45 42 48423 53 4 47 2 56
ASE_00138 0.51 0.49 0.53 40 40395 36 4 31 1 41
ASE_00140 0.62 0.57 0.67 71 70770 38 6 29 3 54
ASE_00146 0.55 0.52 0.59 64 70768 50 2 42 6 60
ASE_00153 0.66 0.67 0.65 49 57555 68 2 24 42 24
ASE_00163 0.64 0.63 0.66 59 53211 43 4 27 12 34
ASE_00165 0.64 0.60 0.67 61 52884 31 5 25 1 40
ASE_00170 0.70 0.68 0.72 63 48740 27 2 23 2 30
ASE_00171 0.70 0.69 0.71 65 48425 28 5 21 2 29
ASE_00172 0.62 0.61 0.63 65 58893 41 8 30 3 41
ASE_00174 0.59 0.57 0.62 62 60975 42 6 32 4 47
ASE_00175 0.59 0.59 0.59 63 59925 45 7 36 2 44
ASE_00179 0.64 0.65 0.62 55 44164 35 7 27 1 29
ASE_00180 0.71 0.69 0.74 69 51267 31 2 22 7 31
ASE_00181 0.54 0.53 0.55 56 57528 52 3 43 6 50
ASE_00182 0.60 0.58 0.62 79 84128 49 6 42 1 57
ASE_00183 0.71 0.70 0.72 79 61316 35 2 28 5 34
ASE_00185 0.72 0.70 0.74 89 73416 38 6 25 7 39
ASE_00186 0.73 0.69 0.78 91 78887 30 3 22 5 41
ASE_00190 0.49 0.46 0.52 41 45372 44 7 31 6 49
ASE_00197 0.49 0.46 0.52 67 89123 66 4 59 3 78
ASE_00198 0.61 0.59 0.64 60 52556 40 6 28 6 42
ASE_00203 0.70 0.69 0.72 66 46573 26 7 19 0 30
ASE_00212 0.70 0.67 0.74 99 93827 39 3 32 4 49
ASE_00214 0.72 0.72 0.73 74 56178 36 4 24 8 29
ASE_00215 0.54 0.51 0.57 50 48429 39 4 33 2 49
ASE_00216 0.67 0.68 0.66 56 39255 31 9 20 2 26
ASE_00217 0.40 0.37 0.45 33 40396 48 3 38 7 57
ASE_00221 0.49 0.45 0.54 53 64522 48 3 42 3 64
ASE_00228 0.52 0.53 0.50 46 46879 46 14 32 0 40
ASE_00229 0.61 0.61 0.62 53 42400 33 8 25 0 34
ASE_00231 0.65 0.65 0.65 62 47800 33 5 28 0 34
ASE_00232 0.63 0.64 0.61 54 38415 37 10 24 3 30
ASE_00234 0.58 0.53 0.62 69 75355 47 3 39 5 60
ASE_00238 0.59 0.59 0.60 67 64150 50 2 42 6 47
ASE_00241 0.49 0.49 0.49 43 43868 47 7 38 2 44
ASE_00254 0.49 0.46 0.52 38 36783 39 4 31 4 44
ASE_00255 0.64 0.62 0.66 80 74570 45 7 34 4 50
ASE_00257 0.55 0.55 0.55 53 50944 47 4 39 4 44
ASE_00263 0.62 0.63 0.62 76 70377 49 5 42 2 44
ASE_00267 0.32 0.31 0.34 27 45070 62 5 48 9 61
ASE_00270 0.76 0.73 0.80 94 72272 29 4 20 5 34
ASE_00274 0.45 0.44 0.46 45 55513 54 10 43 1 58
ASE_00277 0.38 0.38 0.38 35 48112 61 9 49 3 56
ASE_00279 0.68 0.66 0.71 67 53206 35 3 25 7 34
ASE_00280 0.36 0.36 0.37 35 51909 65 4 55 6 63
ASE_00282 0.56 0.55 0.57 70 77693 58 5 47 6 57
ASE_00283 0.75 0.73 0.77 78 61675 30 3 20 7 29
ASE_00284 0.62 0.60 0.64 65 58210 44 4 32 8 43
ASE_00285 0.75 0.70 0.80 86 68899 28 3 18 7 36
ASE_00286 0.43 0.42 0.43 39 46574 63 5 47 11 53
ASE_00287 0.59 0.55 0.63 57 54856 39 2 31 6 46
ASE_00292 0.62 0.58 0.66 80 81689 43 2 39 2 58
ASE_00294 0.74 0.68 0.80 117 114335 32 2 27 3 54
ASE_00296 0.25 0.24 0.27 35 91676 98 8 87 3 110
ASE_00297 0.50 0.50 0.51 49 52878 53 4 44 5 49
ASE_00298 0.28 0.27 0.29 31 67420 79 9 68 2 82
ASE_00328 0.40 0.41 0.40 46 72656 75 3 66 6 66
ASE_00332 0.56 0.54 0.59 75 81682 55 2 51 2 63
ASE_00340 0.76 0.73 0.78 62 45977 26 6 11 9 23
ASE_00342 0.57 0.54 0.60 62 62378 41 5 36 0 53
ASE_00361 0.51 0.49 0.53 62 75349 59 7 48 4 65
ASE_00362 0.61 0.60 0.61 55 48115 39 6 29 4 36
ASE_00363 0.53 0.54 0.53 51 51263 47 5 41 1 43
ASE_00364 0.42 0.42 0.43 44 54182 63 4 55 4 61
ASE_00366 0.54 0.56 0.53 55 58549 52 10 39 3 43
ASE_00367 0.28 0.29 0.27 25 42979 68 8 59 1 61
ASE_00369 0.56 0.55 0.58 59 55843 44 4 39 1 48
ASE_00370 0.63 0.63 0.62 53 41820 33 7 25 1 31
ASE_00372 0.63 0.62 0.65 62 51907 39 6 28 5 38
ASE_00374 0.53 0.52 0.54 46 44765 40 8 31 1 42
ASE_00376 0.48 0.46 0.50 48 56857 52 4 44 4 57
ASE_00379 0.57 0.55 0.60 49 45974 41 3 30 8 40
ASE_00382 0.49 0.49 0.50 41 41823 45 6 35 4 43
ASE_00383 0.58 0.55 0.62 58 54521 40 3 33 4 47
ASE_00384 0.41 0.39 0.43 36 48432 58 2 46 10 56
ASE_00386 0.65 0.65 0.65 62 50307 41 3 31 7 34
ASE_00387 0.43 0.43 0.43 45 55841 59 6 53 0 59
ASE_00388 0.43 0.42 0.44 37 45669 53 3 44 6 52
ASE_00390 0.44 0.42 0.47 36 42118 52 6 35 11 49
ASE_00393 0.37 0.35 0.39 33 47811 58 2 49 7 60
ASE_00394 0.69 0.68 0.70 63 46881 29 5 22 2 30
ASE_00395 0.65 0.63 0.68 53 41538 35 1 24 10 31
ASE_00396 0.16 0.16 0.16 13 41535 71 2 66 3 70
ASE_00397 0.54 0.54 0.54 57 54510 51 4 44 3 48
ASE_00398 0.61 0.58 0.65 60 55852 37 1 32 4 44
ASE_00400 0.53 0.53 0.54 56 57866 51 7 41 3 50
ASE_00401 0.52 0.53 0.51 67 76897 65 13 51 1 59
ASE_00402 0.41 0.40 0.43 34 42406 52 7 39 6 51
ASE_00403 0.44 0.42 0.47 45 55849 55 4 47 4 62
ASE_00404 0.55 0.54 0.57 46 42990 43 0 35 8 39
ASE_00411 0.35 0.35 0.35 31 49366 63 7 51 5 58
ASE_00413 0.55 0.58 0.52 47 44461 44 13 30 1 34
ASE_00415 0.51 0.51 0.51 53 54843 53 7 43 3 50
ASE_00416 0.65 0.61 0.68 78 77307 43 0 36 7 49
ASE_00419 0.75 0.73 0.78 75 54850 26 5 16 5 28
ASE_00422 0.44 0.44 0.45 41 46880 56 5 45 6 53
ASE_00428 0.51 0.50 0.53 62 76520 58 5 49 4 63
ASE_00430 0.64 0.63 0.66 61 46878 39 5 27 7 36
ASE_00437 0.42 0.39 0.46 53 79285 64 4 59 1 82
ASE_00441 0.77 0.72 0.83 81 64163 30 1 16 13 31
ASE_00448 0.22 0.22 0.23 25 64150 91 6 80 5 87
ASE_00451 0.61 0.57 0.66 71 70768 40 2 35 3 54
CRW_00024 0.78 0.77 0.79 351 1085158 132 17 75 40 107
CRW_00048 0.49 0.49 0.50 228 1170758 252 20 209 23 242
CRW_00054 0.46 0.46 0.46 208 1107368 260 31 209 20 248
CRW_00059 0.52 0.51 0.53 240 1172289 233 26 191 16 233
CRW_00061 0.55 0.54 0.55 259 1181483 231 27 184 20 217
CRW_00068 0.49 0.49 0.50 226 1108849 247 24 206 17 231
CRW_00096 0.46 0.46 0.47 214 1178420 264 32 214 18 251
CRW_00140 0.64 0.63 0.64 291 1135826 182 20 141 21 172
CRW_00141 0.59 0.58 0.60 274 1201566 212 26 159 27 202
CRW_00150 0.42 0.41 0.42 193 1152465 282 35 228 19 273
CRW_00152 0.64 0.62 0.65 293 1179965 180 30 128 22 178
CRW_00166 0.54 0.53 0.55 248 1190745 226 28 175 23 220
CRW_00173 0.29 0.29 0.29 127 1082216 323 37 276 10 318
CRW_00177 0.44 0.43 0.45 203 1178433 259 22 222 15 270
CRW_00196 0.47 0.46 0.48 220 1207772 267 24 219 24 255
CRW_00230 0.57 0.56 0.58 266 1198467 216 21 172 23 212
CRW_00245 0.38 0.38 0.38 172 1105880 289 44 232 13 281
CRW_00248 0.57 0.57 0.58 274 1218666 234 21 180 33 210
CRW_00250 0.44 0.44 0.45 210 1198459 274 34 223 17 268
CRW_00256 0.41 0.40 0.42 188 1192291 278 39 222 17 280
CRW_00270 0.44 0.43 0.45 196 1111850 260 40 200 20 259
CRW_00271 0.51 0.50 0.51 231 1122302 237 43 175 19 231
CRW_00273 0.59 0.58 0.60 258 1085174 195 26 143 26 188
CRW_00275 0.47 0.47 0.48 213 1114826 258 28 204 26 244
CRW_00277 0.38 0.38 0.38 172 1110338 300 45 240 15 281
CRW_00278 0.41 0.40 0.42 180 1129825 274 33 218 23 270
CRW_00279 0.51 0.49 0.53 229 1179985 227 29 173 25 235
CRW_00280 0.51 0.50 0.51 227 1117817 231 28 188 15 226
CRW_00281 0.30 0.30 0.29 138 1144872 347 41 290 16 326
CRW_00284 0.28 0.27 0.28 124 1131316 337 30 290 17 332
CRW_00285 0.72 0.71 0.74 325 1117819 142 23 93 26 133
CRW_00289 0.46 0.45 0.48 214 1189204 258 34 201 23 262
CRW_00298 0.19 0.20 0.18 99 1620353 490 81 367 42 395
CRW_00301 0.30 0.31 0.30 162 1761957 428 86 298 44 357
CRW_00310 0.29 0.30 0.28 157 1805386 453 81 326 46 364
CRW_00326 0.41 0.41 0.42 204 1627621 339 47 238 54 298
CRW_00330 0.32 0.32 0.31 167 1988474 452 69 305 78 350
CRW_00332 0.18 0.20 0.17 94 1769479 492 105 343 44 383
CRW_00333 0.29 0.30 0.28 153 1891946 449 74 312 63 361
CRW_00345 0.34 0.35 0.33 175 1586340 403 71 285 47 323
CRW_00348 0.25 0.25 0.24 127 1614982 437 68 326 43 376
CRW_00358 0.36 0.36 0.35 183 1674845 391 61 276 54 324
CRW_00366 0.35 0.36 0.33 174 1579230 395 88 261 46 308
CRW_00370 0.28 0.28 0.28 143 1640248 420 77 298 45 363
CRW_00371 0.29 0.29 0.28 145 1611389 409 77 299 33 351
CRW_00372 0.36 0.36 0.35 181 1625787 378 59 279 40 317
CRW_00379 0.42 0.43 0.41 227 2126401 423 55 270 98 307
CRW_00386 0.24 0.25 0.23 129 1750683 478 83 361 34 386
CRW_00403 0.31 0.31 0.30 146 1606035 431 65 282 84 318
CRW_00411 0.34 0.34 0.34 169 1615006 381 62 266 53 327
CRW_00414 0.27 0.28 0.26 140 1665694 436 77 314 45 355
CRW_00466 0.60 0.59 0.62 268 1116330 196 21 146 29 190
CRW_00589 0.18 0.18 0.18 78 1094024 374 34 324 16 367
CRW_00590 0.36 0.36 0.37 161 1119326 290 30 239 21 291
CRW_00591 0.57 0.56 0.59 251 1098476 205 23 153 29 195
CRW_00598 0.31 0.33 0.29 162 1665675 440 88 300 52 329
CRW_00758 0.29 0.30 0.29 144 1640268 416 66 288 62 339
CRW_00759 0.22 0.22 0.21 107 1636633 462 78 327 57 374
CRW_00760 0.28 0.29 0.28 140 1638458 411 74 283 54 346
CRW_00772 0.26 0.25 0.26 103 945610 313 37 250 26 301
CRW_00789 0.36 0.36 0.36 160 1137342 302 44 240 18 287
CRW_00795 0.21 0.22 0.21 85 1152511 379 51 274 54 309
CRW_00849 0.49 0.48 0.49 227 1117798 259 23 212 24 243
CRW_01153 0.32 0.32 0.32 160 1606024 390 54 290 46 343
CRW_01171 0.32 0.33 0.31 167 1593473 402 81 284 37 339
CRW_01300 0.36 0.37 0.35 189 1693186 392 71 274 47 326
PDB_00571 -0.01 0.00 0.00 0 3302 20 5 14 1 25
PDB_00703 0.53 0.50 0.56 246 1073408 220 17 174 29 249
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.82 0.71 0.94 17 2260 1 0 1 0 7
PDB_00854 0.55 0.53 0.56 284 1500271 276 22 201 53 251
PDB_01088 0.36 0.35 0.37 191 1470959 352 45 275 32 356
PDB_01103 0.56 0.54 0.58 306 1605999 254 32 191 31 256
PDB_01105 0.60 0.58 0.63 313 1433471 221 15 172 34 227
PDB_01120 0.46 0.43 0.49 228 1204659 250 31 210 9 299
PDB_01273 0.51 0.48 0.53 237 1117812 242 21 190 31 254
RFA_00599 0.67 0.70 0.64 78 101353 66 16 28 22 33
RFA_00601 0.09 0.11 0.08 12 99092 139 35 96 8 102
RFA_00602 0.50 0.53 0.47 62 101344 91 18 51 22 54
TMR_00038 0.25 0.25 0.25 28 71140 89 12 73 4 82
TMR_00046 0.47 0.48 0.46 46 62734 61 10 45 6 50
TMR_00048 0.35 0.37 0.34 35 64876 73 9 60 4 60
TMR_00458 0.22 0.22 0.23 20 63458 76 7 61 8 73
TMR_00568 0.57 0.57 0.58 56 60629 50 3 38 9 43

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.