CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(seed)		CMfinder(seed)
MCC	0.473	>	0.363
Average MCC ± 95% Confidence Intervals	0.546 ± 0.070	>	0.399 ± 0.081
Sensitivity	0.295	>	0.184
Positive Predictive Value	0.759	>	0.716
Total TP	507	>	317
Total TN	1069918	<	1070143
Total FP	229	>	134
Total FP CONTRA	23	>	6
Total FP INCONS	138	>	120
Total FP COMP	68	>	8
Total FN	1212	<	1402
P-value	5.19332990918e-08

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Performance plots

Comparison of performance of CentroidAlifold(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and CMfinder(seed)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	507
Total TN	1069918
Total FP	229
Total FP CONTRA	23
Total FP INCONS	138
Total FP COMP	68
Total FN	1212

Total Scores
MCC	0.473
Average MCC ± 95% Confidence Intervals	0.546 ± 0.070
Sensitivity	0.295
Positive Predictive Value	0.759
Nr of predictions	26

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.21	0.65	24	103703	17	1	12	4	91
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.20	0.65	24	77384	16	1	12	3	96
CRW_00610	Intron_gpI links to Rfam database...	0.51	0.33	0.77	27	36280	11	1	7	3	54
CRW_00613	Intron_gpI links to Rfam database...	0.48	0.32	0.71	25	34945	14	0	10	4	53
CRW_00614	Intron_gpI links to Rfam database...	0.43	0.30	0.63	17	121744	16	2	8	6	40
CRW_00618	Intron_gpI links to Rfam database...	0.41	0.28	0.61	17	56252	12	3	8	1	44
CRW_00633	Intron_gpI links to Rfam database...	0.31	0.17	0.58	18	63515	14	2	11	1	88
CRW_00634	Intron_gpI links to Rfam database...	0.35	0.20	0.61	19	64589	20	1	11	8	75
CRW_00670	Intron_gpI links to Rfam database...	0.49	0.28	0.89	33	70088	8	0	4	4	87
CRW_00671	Intron_gpI links to Rfam database...	0.50	0.28	0.89	33	62798	8	0	4	4	84
CRW_00672	Intron_gpI links to Rfam database...	0.51	0.30	0.89	33	72353	8	0	4	4	78
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.16	0.54	20	83399	20	6	11	3	104
CRW_00676	Intron_gpI links to Rfam database...	0.35	0.17	0.69	20	93499	20	0	9	11	95
CRW_00692	Intron_gpI links to Rfam database...	0.39	0.22	0.69	20	68606	20	0	9	11	70
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.80	0.64	1.00	9	937	0	0	0	0	5
PDB_00716	HDV_ribozyme links to Rfam database...	0.75	0.61	0.93	14	2686	1	0	1	0	9
PDB_00827	Intron_gpI links to Rfam database...	0.58	0.40	0.84	32	26990	6	1	5	0	49
PDB_01092	glmS links to Rfam database...	0.72	0.58	0.91	30	10120	4	0	3	1	22
RFA_00632	HDV_ribozyme links to Rfam database...	0.74	0.64	0.86	18	4074	3	2	1	0	10
RFA_00636	HDV_ribozyme links to Rfam database...	0.78	0.68	0.90	19	3984	2	2	0	0	9
RFA_00769	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	2006	0	0	0	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.65	0.56	0.75	9	2004	3	1	2	0	7
RFA_00809	RydC links to Rfam database...	0.43	0.38	0.50	6	2133	6	0	6	0	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	317
Total TN	1070143
Total FP	134
Total FP CONTRA	6
Total FP INCONS	120
Total FP COMP	8
Total FN	1402

Total Scores
MCC	0.363
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081
Sensitivity	0.184
Positive Predictive Value	0.716
Nr of predictions	26

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]