CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidHomfold‑LAST		CMfinder(seed)
MCC	0.651	>	0.363
Average MCC ± 95% Confidence Intervals	0.616 ± 0.061	>	0.399 ± 0.081
Sensitivity	0.493	>	0.184
Positive Predictive Value	0.860	>	0.716
Total TP	848	>	317
Total TN	1069600	<	1070143
Total FP	198	>	134
Total FP CONTRA	26	>	6
Total FP INCONS	112	<	120
Total FP COMP	60	>	8
Total FN	871	<	1402
P-value	5.23657817852e-08

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Performance plots

Comparison of performance of CentroidHomfold-LAST and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(seed)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP	848
Total TN	1069600
Total FP	198
Total FP CONTRA	26
Total FP INCONS	112
Total FP COMP	60
Total FN	871

Total Scores
MCC	0.651
Average MCC ± 95% Confidence Intervals	0.616 ± 0.061
Sensitivity	0.493
Positive Predictive Value	0.860
Nr of predictions	26

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.62	0.42	0.92	48	103688	4	0	4	0	67
CRW_00016	Intron_gpI links to Rfam database...	0.70	0.50	0.97	60	77359	2	0	2	0	60
CRW_00610	Intron_gpI links to Rfam database...	0.66	0.46	0.95	37	36276	2	0	2	0	44
CRW_00613	Intron_gpI links to Rfam database...	0.74	0.55	1.00	43	34937	0	0	0	0	35
CRW_00614	Intron_gpI links to Rfam database...	0.21	0.18	0.25	10	121731	73	7	23	43	47
CRW_00618	Intron_gpI links to Rfam database...	0.38	0.25	0.58	15	56254	20	1	10	9	46
CRW_00633	Intron_gpI links to Rfam database...	0.64	0.42	0.98	45	63500	2	1	0	1	61
CRW_00634	Intron_gpI links to Rfam database...	0.69	0.54	0.88	51	64562	7	1	6	0	43
CRW_00670	Intron_gpI links to Rfam database...	0.69	0.50	0.95	60	70062	3	0	3	0	60
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.48	0.92	56	62774	5	1	4	0	61
CRW_00672	Intron_gpI links to Rfam database...	0.69	0.50	0.96	55	72333	3	0	2	1	56
CRW_00674	Intron_gpI links to Rfam database...	0.76	0.57	1.00	71	83365	1	0	0	1	53
CRW_00676	Intron_gpI links to Rfam database...	0.73	0.55	0.98	63	93464	3	0	1	2	52
CRW_00692	Intron_gpI links to Rfam database...	0.82	0.70	0.95	63	68569	3	0	3	0	27
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.70	0.50	1.00	7	939	0	0	0	0	7
PDB_00716	HDV_ribozyme links to Rfam database...	0.25	0.22	0.29	5	2684	12	0	12	0	18
PDB_00827	Intron_gpI links to Rfam database...	0.73	0.54	0.98	44	26983	2	0	1	1	37
PDB_01092	glmS links to Rfam database...	0.74	0.60	0.91	31	10119	5	0	3	2	21
RFA_00632	HDV_ribozyme links to Rfam database...	0.51	0.50	0.52	14	4068	13	3	10	0	14
RFA_00636	HDV_ribozyme links to Rfam database...	0.64	0.64	0.64	18	3977	10	3	7	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1934	9	4	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.58	0.39	0.88	7	2008	1	0	1	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	2	4	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	4	0	4	0	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	317
Total TN	1070143
Total FP	134
Total FP CONTRA	6
Total FP INCONS	120
Total FP COMP	8
Total FN	1402

Total Scores
MCC	0.363
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081
Sensitivity	0.184
Positive Predictive Value	0.716
Nr of predictions	26

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]