CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	ContextFold		Carnac(seed)
MCC	0.677	>	0.253
Average MCC ± 95% Confidence Intervals	0.621 ± 0.059	>	0.107 ± 0.067
Sensitivity	0.640	>	0.068
Positive Predictive Value	0.716	<	0.940
Total TP	3401	>	362
Total TN	4544449	<	4548811
Total FP	1911	>	40
Total FP CONTRA	281	>	9
Total FP INCONS	1065	>	14
Total FP COMP	565	>	17
Total FN	1913	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of ContextFold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ContextFold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Carnac(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP	3401
Total TN	4544449
Total FP	1911
Total FP CONTRA	281
Total FP INCONS	1065
Total FP COMP	565
Total FN	1913

Total Scores
MCC	0.677
Average MCC ± 95% Confidence Intervals	0.621 ± 0.059
Sensitivity	0.640
Positive Predictive Value	0.716
Nr of predictions	62

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.88	0.83	0.94	62	34125	7	0	4	3	13
ASE_00002	RNaseP_arch links to Rfam database...	0.64	0.60	0.69	44	35447	25	4	16	5	29
ASE_00009	RNaseP_arch links to Rfam database...	0.84	0.79	0.90	53	26047	6	0	6	0	14
ASE_00014	RNaseP_arch links to Rfam database...	0.70	0.65	0.75	69	54193	26	1	22	3	37
ASE_00116	RNaseP_arch links to Rfam database...	0.90	0.85	0.97	56	31568	2	0	2	0	10
ASE_00120	RNaseP_arch links to Rfam database...	0.82	0.73	0.92	69	46896	7	2	4	1	25
ASE_00121	RNaseP_arch links to Rfam database...	0.85	0.77	0.95	71	45075	5	2	2	1	21
ASE_00145	RNaseP_arch links to Rfam database...	0.80	0.78	0.81	87	70018	25	4	16	5	24
ASE_00148	RNaseP_arch links to Rfam database...	0.85	0.80	0.90	123	112438	17	2	12	3	31
ASE_00154	RNaseP_arch links to Rfam database...	0.69	0.66	0.72	71	65243	31	3	24	4	36
ASE_00155	RNaseP_arch links to Rfam database...	0.87	0.80	0.94	114	93407	12	0	7	5	28
ASE_00187	RNaseP_arch links to Rfam database...	0.78	0.71	0.85	82	68539	16	2	12	2	33
ASE_00196	RNaseP_arch links to Rfam database...	0.78	0.75	0.82	56	31558	14	2	10	2	19
ASE_00205	RNaseP_arch links to Rfam database...	0.64	0.61	0.68	55	45975	32	1	25	6	35
ASE_00209	RNaseP_arch links to Rfam database...	0.59	0.55	0.63	48	42995	28	1	27	0	40
ASE_00210	RNaseP_arch links to Rfam database...	0.70	0.69	0.71	45	27198	20	3	15	2	20
ASE_00213	RNaseP_arch links to Rfam database...	0.87	0.82	0.93	54	27203	6	0	4	2	12
ASE_00222	RNaseP_arch links to Rfam database...	0.75	0.69	0.82	108	111969	27	2	22	3	49
ASE_00346	RNaseP_arch links to Rfam database...	0.61	0.58	0.64	56	48118	32	2	29	1	41
ASE_00359	RNaseP_arch links to Rfam database...	0.73	0.69	0.79	55	42708	17	2	13	2	25
ASE_00360	RNaseP_arch links to Rfam database...	0.73	0.65	0.82	42	29352	9	0	9	0	23
ASE_00417	RNaseP_arch links to Rfam database...	0.83	0.76	0.90	76	54531	11	0	8	3	24
ASE_00418	RNaseP_arch links to Rfam database...	0.84	0.77	0.91	58	38717	9	0	6	3	17
CRW_00013	Intron_gpI links to Rfam database...	0.67	0.60	0.76	69	103649	34	4	18	12	46
CRW_00016	Intron_gpI links to Rfam database...	0.81	0.73	0.92	87	77326	14	3	5	6	33
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.95	0.92	0.98	423	1085170	15	3	5	7	35
CRW_00610	Intron_gpI links to Rfam database...	0.87	0.80	0.94	65	36246	7	1	3	3	16
CRW_00613	Intron_gpI links to Rfam database...	0.47	0.42	0.53	33	34918	36	3	26	7	45
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.14	0.14	8	121715	98	13	35	50	49
CRW_00618	Intron_gpI links to Rfam database...	0.21	0.21	0.21	13	56218	64	9	40	15	48
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	164974	131	8	43	80	73
CRW_00620	Intron_gpI links to Rfam database...	0.31	0.32	0.31	20	150910	112	14	31	67	43
CRW_00621	Intron_gpI links to Rfam database...	0.44	0.41	0.48	29	153121	120	6	25	89	42
CRW_00623	Intron_gpI links to Rfam database...	0.35	0.30	0.41	25	129734	101	6	30	65	58
CRW_00633	Intron_gpI links to Rfam database...	0.81	0.75	0.86	80	63453	15	4	9	2	26
CRW_00634	Intron_gpI links to Rfam database...	0.62	0.62	0.62	58	64526	36	9	27	0	36
CRW_00670	Intron_gpI links to Rfam database...	0.86	0.83	0.90	99	70015	11	4	7	0	21
CRW_00671	Intron_gpI links to Rfam database...	0.83	0.79	0.88	92	62731	12	3	9	0	25
CRW_00672	Intron_gpI links to Rfam database...	0.86	0.84	0.89	93	72285	13	4	8	1	18
CRW_00674	Intron_gpI links to Rfam database...	0.81	0.77	0.85	95	83324	19	1	16	2	29
CRW_00676	Intron_gpI links to Rfam database...	0.60	0.57	0.63	66	93424	41	9	29	3	49
CRW_00692	Intron_gpI links to Rfam database...	0.77	0.73	0.81	66	68554	24	6	9	9	24
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.42	0.36	0.50	5	936	5	0	5	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2687	14	0	14	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.79	0.65	0.96	53	26973	3	0	2	1	28
PDB_01092	glmS links to Rfam database...	0.70	0.63	0.77	33	10110	12	1	9	2	19
RFA_00597	Telomerase-vert links to Rfam database...	0.40	0.40	0.39	44	97791	79	14	54	11	65
RFA_00598	Telomerase-vert links to Rfam database...	0.45	0.45	0.46	45	84568	67	11	42	14	56
RFA_00599	Telomerase-vert links to Rfam database...	0.27	0.27	0.27	30	101365	98	14	66	18	81
RFA_00600	Telomerase-vert links to Rfam database...	0.23	0.24	0.21	24	120183	108	34	54	20	76
RFA_00601	Telomerase-vert links to Rfam database...	0.33	0.35	0.32	40	99109	96	28	58	10	74
RFA_00602	Telomerase-vert links to Rfam database...	0.52	0.53	0.51	61	101356	72	21	37	14	55
RFA_00632	HDV_ribozyme links to Rfam database...	0.25	0.25	0.26	7	4068	20	1	19	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.52	0.43	0.63	12	3986	7	0	7	0	16
RFA_00767	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	3	3	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1876	5	2	3	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	4	4	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	2001	5	2	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1938	5	2	3	0	8
RFA_00808	RydC links to Rfam database...	0.58	0.44	0.78	7	2007	2	0	2	0	9
RFA_00809	RydC links to Rfam database...	0.39	0.31	0.50	5	2135	6	0	5	1	11

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

2. Individual counts for ContextFold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]