CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Contrafold		Carnac(seed)
MCC	0.568	>	0.253
Average MCC ± 95% Confidence Intervals	0.548 ± 0.046	>	0.107 ± 0.067
Sensitivity	0.557	>	0.068
Positive Predictive Value	0.579	<	0.940
Total TP	2960	>	362
Total TN	4544087	<	4548811
Total FP	2928	>	40
Total FP CONTRA	384	>	9
Total FP INCONS	1765	>	14
Total FP COMP	779	>	17
Total FN	2354	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Contrafold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP	2960
Total TN	4544087
Total FP	2928
Total FP CONTRA	384
Total FP INCONS	1765
Total FP COMP	779
Total FN	2354

Total Scores
MCC	0.568
Average MCC ± 95% Confidence Intervals	0.548 ± 0.046
Sensitivity	0.557
Positive Predictive Value	0.579
Nr of predictions	62

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.80	0.77	0.83	58	34121	21	3	9	9	17
ASE_00002	RNaseP_arch links to Rfam database...	0.59	0.56	0.61	41	35444	30	2	24	4	32
ASE_00009	RNaseP_arch links to Rfam database...	0.66	0.64	0.68	43	26043	23	1	19	3	24
ASE_00014	RNaseP_arch links to Rfam database...	0.53	0.53	0.53	56	54179	54	6	44	4	50
ASE_00116	RNaseP_arch links to Rfam database...	0.46	0.42	0.50	28	31570	31	0	28	3	38
ASE_00120	RNaseP_arch links to Rfam database...	0.60	0.57	0.64	54	46886	31	6	25	0	40
ASE_00121	RNaseP_arch links to Rfam database...	0.28	0.27	0.29	25	45063	64	6	56	2	67
ASE_00145	RNaseP_arch links to Rfam database...	0.60	0.59	0.60	66	70015	50	7	37	6	45
ASE_00148	RNaseP_arch links to Rfam database...	0.79	0.78	0.81	120	112426	34	5	24	5	34
ASE_00154	RNaseP_arch links to Rfam database...	0.74	0.72	0.76	77	65240	31	2	22	7	30
ASE_00155	RNaseP_arch links to Rfam database...	0.60	0.58	0.61	83	93392	56	4	49	3	59
ASE_00187	RNaseP_arch links to Rfam database...	0.38	0.37	0.40	42	68531	68	5	57	6	73
ASE_00196	RNaseP_arch links to Rfam database...	0.75	0.76	0.74	57	31549	26	2	18	6	18
ASE_00205	RNaseP_arch links to Rfam database...	0.45	0.46	0.45	41	45964	60	7	44	9	49
ASE_00209	RNaseP_arch links to Rfam database...	0.56	0.51	0.61	45	42997	31	3	26	2	43
ASE_00210	RNaseP_arch links to Rfam database...	0.58	0.60	0.57	39	27192	31	7	23	1	26
ASE_00213	RNaseP_arch links to Rfam database...	0.58	0.58	0.58	38	27196	30	5	22	3	28
ASE_00222	RNaseP_arch links to Rfam database...	0.72	0.71	0.74	111	111950	46	7	33	6	46
ASE_00346	RNaseP_arch links to Rfam database...	0.34	0.34	0.35	33	48111	67	4	57	6	64
ASE_00359	RNaseP_arch links to Rfam database...	0.49	0.48	0.51	38	42703	44	3	34	7	42
ASE_00360	RNaseP_arch links to Rfam database...	0.31	0.31	0.32	20	29341	43	8	34	1	45
ASE_00417	RNaseP_arch links to Rfam database...	0.47	0.47	0.47	47	54516	55	2	50	3	53
ASE_00418	RNaseP_arch links to Rfam database...	0.06	0.07	0.07	5	38706	72	5	65	2	70
CRW_00013	Intron_gpI links to Rfam database...	0.43	0.39	0.47	45	103644	80	11	40	29	70
CRW_00016	Intron_gpI links to Rfam database...	0.73	0.68	0.79	81	77319	37	0	21	16	39
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.77	0.78	351	1085153	140	12	85	43	107
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.49	0.51	40	36237	41	9	29	3	41
CRW_00613	Intron_gpI links to Rfam database...	0.79	0.77	0.81	60	34906	22	1	13	8	18
CRW_00614	Intron_gpI links to Rfam database...	0.24	0.25	0.23	14	121709	121	7	41	73	43
CRW_00618	Intron_gpI links to Rfam database...	0.20	0.21	0.19	13	56213	75	8	46	21	48
CRW_00619	Intron_gpI links to Rfam database...	0.45	0.40	0.52	29	164969	110	5	22	83	44
CRW_00620	Intron_gpI links to Rfam database...	0.18	0.22	0.15	14	150884	136	23	54	59	49
CRW_00621	Intron_gpI links to Rfam database...	0.37	0.35	0.38	25	153116	137	6	34	97	46
CRW_00623	Intron_gpI links to Rfam database...	0.25	0.20	0.31	17	129740	100	5	33	62	66
CRW_00633	Intron_gpI links to Rfam database...	0.58	0.55	0.62	58	63453	37	8	27	2	48
CRW_00634	Intron_gpI links to Rfam database...	0.58	0.59	0.57	55	64524	43	12	29	2	39
CRW_00670	Intron_gpI links to Rfam database...	0.76	0.71	0.83	85	70022	19	0	18	1	35
CRW_00671	Intron_gpI links to Rfam database...	0.73	0.70	0.77	82	62728	31	1	24	6	35
CRW_00672	Intron_gpI links to Rfam database...	0.53	0.52	0.55	58	72284	55	8	40	7	53
CRW_00674	Intron_gpI links to Rfam database...	0.70	0.66	0.74	82	83325	34	5	24	5	42
CRW_00676	Intron_gpI links to Rfam database...	0.42	0.44	0.40	51	93400	81	20	57	4	64
CRW_00692	Intron_gpI links to Rfam database...	0.45	0.44	0.47	40	68549	53	16	30	7	50
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.33	0.30	0.37	7	2682	13	0	12	1	16
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.90	53	26969	8	0	6	2	28
PDB_01092	glmS links to Rfam database...	0.70	0.65	0.76	34	10108	14	2	9	3	18
RFA_00597	Telomerase-vert links to Rfam database...	0.60	0.61	0.59	67	97789	69	16	31	22	42
RFA_00598	Telomerase-vert links to Rfam database...	0.47	0.47	0.48	47	84569	79	6	44	29	54
RFA_00599	Telomerase-vert links to Rfam database...	0.71	0.73	0.70	81	101359	59	10	25	24	30
RFA_00600	Telomerase-vert links to Rfam database...	0.67	0.72	0.62	72	120178	86	21	24	41	28
RFA_00601	Telomerase-vert links to Rfam database...	0.33	0.36	0.30	41	99097	108	37	60	11	73
RFA_00602	Telomerase-vert links to Rfam database...	0.63	0.67	0.58	78	101341	68	25	31	12	38
RFA_00632	HDV_ribozyme links to Rfam database...	0.38	0.39	0.37	11	4065	19	0	19	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.60	0.64	0.56	18	3973	14	4	10	0	10
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	2	0	0	2	8
RFA_00768	Corona_pk3 links to Rfam database...	0.45	0.44	0.47	8	1874	9	1	8	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1934	9	4	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	5	0	2	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	4	1	0	3	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	0	2	0	8
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	0	8	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

2. Individual counts for Contrafold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]