CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Fold		Carnac(seed)
MCC	0.494	>	0.253
Average MCC ± 95% Confidence Intervals	0.477 ± 0.055	>	0.107 ± 0.067
Sensitivity	0.497	>	0.068
Positive Predictive Value	0.491	<	0.940
Total TP	2643	>	362
Total TN	4543815	<	4548811
Total FP	3574	>	40
Total FP CONTRA	481	>	9
Total FP INCONS	2257	>	14
Total FP COMP	836	>	17
Total FN	2671	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Fold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Fold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Fold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Fold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Fold and Carnac(seed)).

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Performance of Fold - scored higher in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP	2643
Total TN	4543815
Total FP	3574
Total FP CONTRA	481
Total FP INCONS	2257
Total FP COMP	836
Total FN	2671

Total Scores
MCC	0.494
Average MCC ± 95% Confidence Intervals	0.477 ± 0.055
Sensitivity	0.497
Positive Predictive Value	0.491
Nr of predictions	62

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2. Individual counts for Fold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.84	0.81	0.87	61	34121	17	2	7	8	14
ASE_00002	RNaseP_arch links to Rfam database...	0.70	0.67	0.73	49	35444	21	4	14	3	24
ASE_00009	RNaseP_arch links to Rfam database...	0.38	0.37	0.38	25	26041	42	4	36	2	42
ASE_00014	RNaseP_arch links to Rfam database...	0.42	0.42	0.43	44	54182	67	2	57	8	62
ASE_00116	RNaseP_arch links to Rfam database...	0.20	0.20	0.20	13	31560	56	5	48	3	53
ASE_00120	RNaseP_arch links to Rfam database...	0.50	0.49	0.51	46	46880	45	4	41	0	48
ASE_00121	RNaseP_arch links to Rfam database...	0.25	0.25	0.25	23	45059	70	6	62	2	69
ASE_00145	RNaseP_arch links to Rfam database...	0.45	0.44	0.46	49	70018	68	7	51	10	62
ASE_00148	RNaseP_arch links to Rfam database...	0.67	0.66	0.69	101	112428	49	4	42	3	53
ASE_00154	RNaseP_arch links to Rfam database...	0.58	0.58	0.58	62	65234	49	4	41	4	45
ASE_00155	RNaseP_arch links to Rfam database...	0.60	0.59	0.60	84	93389	61	10	45	6	58
ASE_00187	RNaseP_arch links to Rfam database...	0.30	0.30	0.31	34	68524	84	7	70	7	81
ASE_00196	RNaseP_arch links to Rfam database...	0.80	0.79	0.81	59	31553	21	2	12	7	16
ASE_00205	RNaseP_arch links to Rfam database...	0.44	0.46	0.44	41	45962	56	8	45	3	49
ASE_00209	RNaseP_arch links to Rfam database...	0.40	0.39	0.41	34	42989	49	4	44	1	54
ASE_00210	RNaseP_arch links to Rfam database...	0.65	0.66	0.64	43	27194	25	6	18	1	22
ASE_00213	RNaseP_arch links to Rfam database...	0.74	0.73	0.76	48	27198	16	3	12	1	18
ASE_00222	RNaseP_arch links to Rfam database...	0.53	0.52	0.54	81	111950	70	8	62	0	76
ASE_00346	RNaseP_arch links to Rfam database...	0.53	0.53	0.54	51	48110	52	4	40	8	46
ASE_00359	RNaseP_arch links to Rfam database...	0.09	0.10	0.09	8	42688	82	9	73	0	72
ASE_00360	RNaseP_arch links to Rfam database...	0.31	0.31	0.31	20	29339	50	11	33	6	45
ASE_00417	RNaseP_arch links to Rfam database...	0.35	0.36	0.35	36	54511	70	9	59	2	64
ASE_00418	RNaseP_arch links to Rfam database...	0.20	0.21	0.20	16	38701	67	9	55	3	59
CRW_00013	Intron_gpI links to Rfam database...	0.21	0.21	0.21	24	103627	115	11	78	26	91
CRW_00016	Intron_gpI links to Rfam database...	0.79	0.75	0.83	90	77313	31	5	13	13	30
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.56	0.57	0.56	259	1085140	238	22	180	36	199
CRW_00610	Intron_gpI links to Rfam database...	0.43	0.43	0.42	35	36232	49	9	39	1	46
CRW_00613	Intron_gpI links to Rfam database...	0.89	0.85	0.93	66	34909	13	0	5	8	12
CRW_00614	Intron_gpI links to Rfam database...	0.13	0.16	0.11	9	121688	143	18	56	69	48
CRW_00618	Intron_gpI links to Rfam database...	0.19	0.20	0.18	12	56212	81	8	48	25	49
CRW_00619	Intron_gpI links to Rfam database...	0.36	0.37	0.34	27	164946	145	7	45	93	46
CRW_00620	Intron_gpI links to Rfam database...	0.26	0.30	0.23	19	150891	164	18	47	99	44
CRW_00621	Intron_gpI links to Rfam database...	0.41	0.41	0.42	29	153112	137	9	31	97	42
CRW_00623	Intron_gpI links to Rfam database...	0.19	0.19	0.20	16	129714	133	15	50	68	67
CRW_00633	Intron_gpI links to Rfam database...	0.44	0.43	0.44	46	63441	61	13	46	2	60
CRW_00634	Intron_gpI links to Rfam database...	0.28	0.30	0.26	28	64513	83	12	67	4	66
CRW_00670	Intron_gpI links to Rfam database...	0.54	0.55	0.54	66	70002	59	12	45	2	54
CRW_00671	Intron_gpI links to Rfam database...	0.71	0.68	0.74	79	62728	34	1	27	6	38
CRW_00672	Intron_gpI links to Rfam database...	0.75	0.77	0.74	85	72275	40	6	24	10	26
CRW_00674	Intron_gpI links to Rfam database...	0.66	0.67	0.66	83	83310	52	9	34	9	41
CRW_00676	Intron_gpI links to Rfam database...	0.55	0.57	0.54	66	93405	75	12	45	18	49
CRW_00692	Intron_gpI links to Rfam database...	0.23	0.24	0.21	22	68530	90	27	56	7	68
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2678	24	1	22	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.65	0.59	0.72	48	26961	21	0	19	2	33
PDB_01092	glmS links to Rfam database...	0.73	0.63	0.85	33	10114	8	0	6	2	19
RFA_00597	Telomerase-vert links to Rfam database...	0.27	0.29	0.26	32	97779	107	18	74	15	77
RFA_00598	Telomerase-vert links to Rfam database...	0.69	0.66	0.71	67	84572	57	4	23	30	34
RFA_00599	Telomerase-vert links to Rfam database...	0.73	0.74	0.72	82	101361	60	10	22	28	29
RFA_00600	Telomerase-vert links to Rfam database...	0.63	0.71	0.56	71	120169	87	30	25	32	29
RFA_00601	Telomerase-vert links to Rfam database...	0.42	0.46	0.39	52	99103	95	33	47	15	62
RFA_00602	Telomerase-vert links to Rfam database...	0.60	0.63	0.57	73	101347	77	23	32	22	43
RFA_00632	HDV_ribozyme links to Rfam database...	0.39	0.39	0.39	11	4067	17	2	15	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00767	Corona_pk3 links to Rfam database...	0.44	0.44	0.44	8	1873	10	1	9	0	10
RFA_00768	Corona_pk3 links to Rfam database...	0.45	0.44	0.47	8	1874	10	1	8	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	2001	8	0	5	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	3	1	0	2	8
RFA_00779	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2000	18	2	14	2	16
RFA_00809	RydC links to Rfam database...	0.37	0.38	0.38	6	2129	10	1	9	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Fold - scored higher in this pairwise comparison

1. Total counts & total scores for Fold

2. Individual counts for Fold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]