CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	IPknot		Carnac(seed)
MCC	0.588	>	0.253
Average MCC ± 95% Confidence Intervals	0.567 ± 0.051	>	0.107 ± 0.067
Sensitivity	0.539	>	0.068
Positive Predictive Value	0.643	<	0.940
Total TP	2862	>	362
Total TN	4544744	<	4548811
Total FP	2113	>	40
Total FP CONTRA	309	>	9
Total FP INCONS	1281	>	14
Total FP COMP	523	>	17
Total FN	2452	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of IPknot and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for IPknot and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and Carnac(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP	2862
Total TN	4544744
Total FP	2113
Total FP CONTRA	309
Total FP INCONS	1281
Total FP COMP	523
Total FN	2452

Total Scores
MCC	0.588
Average MCC ± 95% Confidence Intervals	0.567 ± 0.051
Sensitivity	0.539
Positive Predictive Value	0.643
Nr of predictions	62

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.76	0.73	0.80	55	34122	20	3	11	6	20
ASE_00002	RNaseP_arch links to Rfam database...	0.68	0.62	0.75	45	35451	20	2	13	5	28
ASE_00009	RNaseP_arch links to Rfam database...	0.71	0.67	0.75	45	26046	15	0	15	0	22
ASE_00014	RNaseP_arch links to Rfam database...	0.56	0.50	0.63	53	54201	33	7	24	2	53
ASE_00116	RNaseP_arch links to Rfam database...	0.32	0.24	0.42	16	31588	25	1	21	3	50
ASE_00120	RNaseP_arch links to Rfam database...	0.62	0.55	0.69	52	46896	23	7	16	0	42
ASE_00121	RNaseP_arch links to Rfam database...	0.43	0.37	0.51	34	45083	34	4	29	1	58
ASE_00145	RNaseP_arch links to Rfam database...	0.63	0.53	0.75	59	70046	24	5	15	4	52
ASE_00148	RNaseP_arch links to Rfam database...	0.74	0.69	0.80	106	112443	26	3	23	0	48
ASE_00154	RNaseP_arch links to Rfam database...	0.70	0.64	0.76	68	65252	24	2	19	3	39
ASE_00155	RNaseP_arch links to Rfam database...	0.58	0.52	0.64	74	93412	45	4	38	3	68
ASE_00187	RNaseP_arch links to Rfam database...	0.53	0.43	0.65	49	68560	28	2	24	2	66
ASE_00196	RNaseP_arch links to Rfam database...	0.76	0.75	0.78	56	31554	20	2	14	4	19
ASE_00205	RNaseP_arch links to Rfam database...	0.53	0.49	0.59	44	45981	33	6	25	2	46
ASE_00209	RNaseP_arch links to Rfam database...	0.53	0.49	0.58	43	42997	31	5	26	0	45
ASE_00210	RNaseP_arch links to Rfam database...	0.58	0.58	0.58	38	27195	30	7	21	2	27
ASE_00213	RNaseP_arch links to Rfam database...	0.77	0.67	0.90	44	27212	5	1	4	0	22
ASE_00222	RNaseP_arch links to Rfam database...	0.66	0.62	0.70	98	111961	42	4	38	0	59
ASE_00346	RNaseP_arch links to Rfam database...	0.37	0.34	0.40	33	48123	51	3	46	2	64
ASE_00359	RNaseP_arch links to Rfam database...	0.51	0.43	0.61	34	42722	22	3	19	0	46
ASE_00360	RNaseP_arch links to Rfam database...	0.50	0.45	0.57	29	29352	22	3	19	0	36
ASE_00417	RNaseP_arch links to Rfam database...	0.43	0.41	0.46	41	54525	53	4	45	4	59
ASE_00418	RNaseP_arch links to Rfam database...	0.20	0.19	0.21	14	38714	55	2	51	2	61
CRW_00013	Intron_gpI links to Rfam database...	0.33	0.26	0.42	30	103669	55	7	34	14	85
CRW_00016	Intron_gpI links to Rfam database...	0.75	0.67	0.83	80	77325	26	6	10	10	40
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.83	0.77	0.89	352	1085204	78	4	41	33	106
CRW_00610	Intron_gpI links to Rfam database...	0.61	0.54	0.68	44	36250	21	6	15	0	37
CRW_00613	Intron_gpI links to Rfam database...	0.86	0.78	0.94	61	34915	13	1	3	9	17
CRW_00614	Intron_gpI links to Rfam database...	0.13	0.14	0.13	8	121707	95	15	41	39	49
CRW_00618	Intron_gpI links to Rfam database...	0.25	0.25	0.26	15	56223	56	5	37	14	46
CRW_00619	Intron_gpI links to Rfam database...	0.42	0.30	0.58	22	164987	82	4	12	66	51
CRW_00620	Intron_gpI links to Rfam database...	0.20	0.21	0.19	13	150907	93	14	41	38	50
CRW_00621	Intron_gpI links to Rfam database...	0.35	0.31	0.39	22	153125	120	4	30	86	49
CRW_00623	Intron_gpI links to Rfam database...	0.30	0.23	0.39	19	129746	89	5	25	59	64
CRW_00633	Intron_gpI links to Rfam database...	0.64	0.58	0.72	61	63461	25	5	19	1	45
CRW_00634	Intron_gpI links to Rfam database...	0.60	0.56	0.65	53	64538	30	10	19	1	41
CRW_00670	Intron_gpI links to Rfam database...	0.83	0.78	0.87	94	70017	14	6	8	0	26
CRW_00671	Intron_gpI links to Rfam database...	0.82	0.74	0.92	86	62742	8	1	6	1	31
CRW_00672	Intron_gpI links to Rfam database...	0.76	0.72	0.80	80	72290	24	8	12	4	31
CRW_00674	Intron_gpI links to Rfam database...	0.75	0.69	0.83	85	83333	20	7	11	2	39
CRW_00676	Intron_gpI links to Rfam database...	0.47	0.44	0.51	51	93428	52	14	35	3	64
CRW_00692	Intron_gpI links to Rfam database...	0.56	0.47	0.68	42	68573	21	7	13	1	48
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.71	0.71	0.71	10	932	4	0	4	0	4
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2680	21	0	21	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.79	0.65	0.95	53	26972	5	0	3	2	28
PDB_01092	glmS links to Rfam database...	0.73	0.63	0.85	33	10114	8	1	5	2	19
RFA_00597	Telomerase-vert links to Rfam database...	0.52	0.50	0.55	54	97804	55	4	41	10	55
RFA_00598	Telomerase-vert links to Rfam database...	0.49	0.48	0.51	48	84572	68	5	41	22	53
RFA_00599	Telomerase-vert links to Rfam database...	0.75	0.73	0.77	81	101370	40	8	16	16	30
RFA_00600	Telomerase-vert links to Rfam database...	0.22	0.22	0.21	22	120191	99	29	53	17	78
RFA_00601	Telomerase-vert links to Rfam database...	0.45	0.46	0.43	53	99113	82	25	44	13	61
RFA_00602	Telomerase-vert links to Rfam database...	0.42	0.43	0.40	50	101351	83	20	54	9	66
RFA_00632	HDV_ribozyme links to Rfam database...	0.42	0.36	0.50	10	4075	11	0	10	1	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.65	0.64	0.67	18	3978	9	3	6	0	10
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	1.00	1.00	1.00	18	1873	0	0	0	0	0
RFA_00769	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1934	9	4	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.64	0.50	0.82	9	2005	4	0	2	2	9
RFA_00773	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1938	8	1	4	3	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	4	0	4	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

2. Individual counts for IPknot [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]