CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & NanoFolder [.zip] - may take several seconds...


Overview

Metric IPknot NanoFolder
MCC 0.628 > 0.174
Average MCC ± 95% Confidence Intervals 0.625 ± 0.030 > 0.183 ± 0.028
Sensitivity 0.565 > 0.207
Positive Predictive Value 0.700 > 0.149
Total TP 6172 > 2258
Total TN 6811668 > 6805326
Total FP 3187 < 13384
Total FP CONTRA 523 < 2402
Total FP INCONS 2122 < 10499
Total FP COMP 542 > 483
Total FN 4760 < 8674
P-value 3.56938820447e-08

^top




Performance plots


  1. Comparison of performance of IPknot and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for IPknot and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and NanoFolder).

^top





Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 6172
Total TN 6811668
Total FP 3187
Total FP CONTRA 523
Total FP INCONS 2122
Total FP COMP 542
Total FN 4760
Total Scores
MCC 0.628
Average MCC ± 95% Confidence Intervals 0.625 ± 0.030
Sensitivity 0.565
Positive Predictive Value 0.700
Nr of predictions 112

^top



2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.28 0.31 0.26 20 50962 71 19 39 13 44
ASE_00083 0.77 0.72 0.82 79 62385 22 0 17 5 31
ASE_00122 0.73 0.65 0.83 57 43296 12 0 12 0 31
ASE_00185 0.79 0.69 0.92 88 73440 10 0 8 2 40
ASE_00190 0.75 0.58 0.98 52 45398 3 0 1 2 38
ASE_00196 0.76 0.75 0.78 56 31554 20 2 14 4 19
ASE_00221 0.61 0.46 0.82 54 64554 12 1 11 0 63
ASE_00227 0.33 0.29 0.37 39 78897 67 5 62 0 94
ASE_00228 0.78 0.74 0.82 64 46893 16 6 8 2 22
ASE_00229 0.73 0.63 0.83 55 42420 12 3 8 1 32
ASE_00231 0.74 0.66 0.83 63 47819 13 3 10 0 33
ASE_00234 0.58 0.49 0.70 63 75376 31 2 25 4 66
ASE_00238 0.64 0.54 0.75 62 64178 22 1 20 1 52
ASE_00248 0.71 0.61 0.84 69 62399 15 0 13 2 45
ASE_00250 0.67 0.53 0.85 69 78922 15 4 8 3 62
ASE_00254 0.76 0.68 0.85 56 36790 15 3 7 5 26
ASE_00255 0.72 0.62 0.85 80 74597 14 3 11 0 50
ASE_00257 0.76 0.63 0.91 61 50973 6 1 5 0 36
ASE_00267 0.54 0.42 0.70 37 45097 22 0 16 6 51
ASE_00270 0.76 0.73 0.79 93 72273 26 1 23 2 35
ASE_00274 0.64 0.55 0.75 57 55535 19 5 14 0 46
ASE_00277 0.59 0.53 0.66 48 48132 25 4 21 0 43
ASE_00279 0.73 0.62 0.86 63 53228 10 3 7 0 38
ASE_00285 0.80 0.75 0.86 91 68900 23 3 12 8 31
ASE_00287 0.72 0.69 0.76 71 54853 23 2 20 1 32
ASE_00294 0.78 0.68 0.90 117 114351 14 1 12 1 54
ASE_00295 0.72 0.63 0.84 82 73822 16 3 13 0 49
ASE_00298 0.57 0.51 0.64 58 67438 34 1 31 2 55
ASE_00318 0.52 0.43 0.64 51 80120 32 4 25 3 67
ASE_00335 0.68 0.59 0.78 68 75379 25 2 17 6 48
ASE_00339 0.72 0.63 0.82 75 80108 26 0 17 9 44
ASE_00340 0.76 0.75 0.77 64 45973 25 8 11 6 21
ASE_00343 0.77 0.67 0.87 76 83349 21 0 11 10 37
ASE_00367 0.62 0.55 0.71 47 43005 23 5 14 4 39
ASE_00370 0.49 0.43 0.55 36 41840 29 1 28 0 48
ASE_00372 0.74 0.68 0.80 68 51918 20 3 14 3 32
ASE_00375 0.79 0.70 0.89 77 60291 10 1 9 0 33
ASE_00376 0.62 0.57 0.68 60 56865 30 5 23 2 45
ASE_00377 0.77 0.74 0.81 79 57532 24 3 16 5 28
ASE_00386 0.65 0.60 0.70 58 50320 30 1 24 5 38
ASE_00393 0.72 0.65 0.81 60 47821 15 0 14 1 33
ASE_00412 0.56 0.47 0.67 49 58238 24 7 17 0 56
ASE_00413 0.47 0.46 0.49 37 44475 42 5 34 3 44
ASE_00416 0.71 0.60 0.84 76 77330 20 0 15 5 51
ASE_00417 0.43 0.41 0.46 41 54525 53 4 45 4 59
ASE_00422 0.69 0.65 0.74 61 46889 26 6 15 5 33
ASE_00428 0.65 0.59 0.72 74 76533 33 2 27 4 51
ASE_00429 - 0.59 0.56 0.62 37 28143 24 6 17 1 29
ASE_00430 0.76 0.68 0.85 66 46893 17 3 9 5 31
ASE_00434 0.70 0.60 0.81 66 68184 23 3 12 8 44
ASE_00437 0.55 0.41 0.74 56 79325 20 0 20 0 79
ASE_00451 0.75 0.66 0.85 82 70780 14 2 12 0 43
CRW_00648 - 0.73 0.68 0.79 101 137947 37 9 18 10 47
CRW_00654 - 0.86 0.77 0.96 96 78110 6 0 4 2 28
CRW_00658 - 0.59 0.58 0.60 59 74593 42 16 23 3 43
CRW_00663 - 0.03 0.03 0.04 2 26056 49 8 40 1 59
CRW_00664 - 0.21 0.21 0.23 16 53557 58 9 46 3 62
CRW_00671 0.82 0.74 0.92 86 62742 8 1 6 1 31
CRW_00672 0.76 0.72 0.80 80 72290 24 8 12 4 31
CRW_00674 0.75 0.69 0.83 85 83333 20 7 11 2 39
CRW_00676 0.47 0.44 0.51 51 93428 52 14 35 3 64
CRW_00685 - 0.60 0.58 0.63 61 156983 60 15 21 24 45
CRW_00688 - 0.83 0.81 0.85 46 21891 9 3 5 1 11
CRW_00721 - 0.73 0.62 0.86 42 58604 21 1 6 14 26
PDB_00078 - 0.54 0.52 0.57 60 49664 46 5 41 0 55
PDB_00278 - 0.42 0.38 0.48 27 24920 29 1 28 0 45
PDB_00571 0.79 0.76 0.83 19 3298 4 2 2 0 6
PDB_00701 - 0.38 0.37 0.39 40 45348 63 9 54 0 69
PDB_00828 0.90 0.81 1.00 22 2463 0 0 0 0 5
PDB_00851 - 0.45 0.39 0.53 16 4723 14 0 14 0 25
PDB_00917 - 0.58 0.54 0.64 51 35165 34 2 27 5 44
PDB_01009 0.71 0.81 0.63 17 2458 10 5 5 0 4
RFA_00770 0.64 0.50 0.82 9 2005 4 0 2 2 9
RFA_00773 0.61 0.56 0.67 10 1938 8 1 4 3 8
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
TMR_00036 0.65 0.59 0.71 60 90441 51 6 18 27 41
TMR_00123 0.85 0.77 0.93 78 66346 11 0 6 5 23
TMR_00180 0.69 0.66 0.73 65 67072 36 5 19 12 34
TMR_00240 0.62 0.58 0.67 49 63117 30 10 14 6 36
TMR_00352 0.25 0.23 0.28 17 95205 77 11 33 33 58
TMR_00353 0.53 0.52 0.54 55 84154 56 15 31 10 50
TMR_00357 0.52 0.49 0.56 45 82948 53 16 19 18 47
TMR_00361 - 0.37 0.40 0.35 29 93445 72 21 33 18 43
TMR_00374 0.45 0.42 0.47 39 81727 48 7 37 4 53
TMR_00384 0.44 0.31 0.61 34 65647 26 0 22 4 74
TMR_00395 0.81 0.72 0.91 78 64534 13 4 4 5 31
TMR_00398 0.78 0.69 0.89 73 65259 15 0 9 6 33
TMR_00399 0.41 0.33 0.51 31 64919 37 11 19 7 63
TMR_00430 0.27 0.23 0.33 25 82545 51 13 38 0 84
TMR_00431 0.82 0.69 0.97 38 51964 34 1 0 33 17
TMR_00443 0.65 0.55 0.77 57 67087 24 8 9 7 47
TMR_00457 0.51 0.48 0.53 49 78514 48 5 38 5 53
TMR_00469 0.52 0.51 0.54 51 64525 48 16 28 4 49
TMR_00502 0.47 0.41 0.54 38 75396 39 7 25 7 55
TMR_00503 0.76 0.69 0.84 77 67804 23 3 12 8 34
TMR_00519 0.44 0.35 0.57 33 63132 35 7 18 10 62
TMR_00528 0.43 0.40 0.46 39 63106 55 11 34 10 58
TMR_00541 0.62 0.61 0.63 64 61674 44 3 35 6 41
TMR_00547 0.55 0.49 0.62 49 65262 32 1 29 2 51
TMR_00562 0.59 0.61 0.57 62 72663 53 13 33 7 40
TMR_00566 0.68 0.58 0.79 58 60653 22 2 13 7 42
TMR_00571 0.68 0.60 0.79 59 60651 24 2 14 8 40
TMR_00584 0.61 0.59 0.64 57 60986 36 3 29 4 40
TMR_00594 0.48 0.39 0.59 41 79332 31 6 22 3 63
TMR_00605 0.56 0.50 0.62 54 74218 37 8 25 4 54
TMR_00609 0.73 0.67 0.78 76 63449 21 4 17 0 37
TMR_00624 0.83 0.74 0.93 80 62395 14 3 3 8 28
TMR_00683 0.26 0.23 0.29 23 82949 65 14 42 9 77
TMR_00698 0.58 0.50 0.68 52 63113 28 6 19 3 52
TMR_00703 0.53 0.45 0.61 45 67454 34 3 26 5 54
TMR_00706 0.64 0.60 0.67 62 66338 33 3 27 3 41
TMR_00711 0.60 0.58 0.61 57 67803 39 12 24 3 41

^top



Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 2258
Total TN 6805326
Total FP 13384
Total FP CONTRA 2402
Total FP INCONS 10499
Total FP COMP 483
Total FN 8674
Total Scores
MCC 0.174
Average MCC ± 95% Confidence Intervals 0.183 ± 0.028
Sensitivity 0.207
Positive Predictive Value 0.149
Nr of predictions 112

^top



2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.02 0.03 0.02 2 50914 131 38 86 7 62
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00122 0.27 0.30 0.24 26 43258 84 13 68 3 62
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00196 0.49 0.57 0.42 43 31524 62 16 43 3 32
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00227 0.28 0.31 0.25 41 78840 122 20 102 0 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00231 0.37 0.42 0.33 40 47773 84 17 65 2 56
ASE_00234 0.25 0.27 0.23 35 75315 117 10 106 1 94
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00248 0.13 0.15 0.12 17 62340 124 9 115 0 97
ASE_00250 0.25 0.29 0.23 38 78835 135 17 113 5 93
ASE_00254 0.15 0.16 0.14 13 36761 88 3 79 6 69
ASE_00255 0.11 0.12 0.10 16 74530 146 16 129 1 114
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00274 0.00 0.00 0.00 0 55487 126 12 112 2 103
ASE_00277 0.10 0.12 0.08 11 48071 123 23 100 0 80
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00287 0.15 0.17 0.14 17 54824 107 14 91 2 86
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00295 0.14 0.16 0.13 21 73761 140 19 119 2 110
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00318 0.03 0.04 0.03 5 80039 156 21 135 0 113
ASE_00335 0.10 0.12 0.09 14 75304 151 22 126 3 102
ASE_00339 0.25 0.29 0.22 34 80042 129 20 104 5 85
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00343 0.14 0.17 0.12 19 83275 145 31 111 3 94
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00370 0.03 0.04 0.03 3 41796 109 18 88 3 81
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00375 0.12 0.14 0.11 15 60246 120 10 107 3 95
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00377 0.25 0.27 0.23 29 57505 98 10 86 2 78
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00413 0.08 0.10 0.07 8 44438 108 19 86 3 73
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00417 0.32 0.36 0.28 36 54486 98 18 75 5 64
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00429 - 0.08 0.09 0.07 6 28114 84 14 69 1 60
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00434 0.29 0.34 0.25 37 68116 122 20 92 10 73
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
CRW_00648 - 0.05 0.06 0.04 9 137864 213 24 178 11 139
CRW_00654 - 0.41 0.47 0.36 58 78049 105 18 85 2 66
CRW_00658 - 0.21 0.26 0.16 27 74527 137 28 109 0 75
CRW_00663 - 0.08 0.10 0.07 6 26014 90 17 69 4 55
CRW_00664 - 0.14 0.19 0.11 15 53486 134 42 85 7 63
CRW_00671 0.18 0.21 0.16 24 62682 130 23 106 1 93
CRW_00672 0.36 0.43 0.31 48 72233 114 35 74 5 63
CRW_00674 0.16 0.19 0.14 23 83274 142 19 120 3 101
CRW_00676 0.11 0.14 0.09 16 93347 169 29 136 4 99
CRW_00685 - 0.11 0.15 0.08 16 156867 212 64 133 15 90
CRW_00688 - 0.33 0.40 0.27 23 21859 64 21 42 1 34
CRW_00721 - 0.22 0.31 0.15 21 58515 133 46 71 16 47
PDB_00078 - 0.00 0.00 0.00 0 49644 126 10 116 0 115
PDB_00278 - 0.04 0.06 0.04 4 24875 98 13 84 1 68
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00701 - 0.04 0.05 0.04 5 45319 127 14 113 0 104
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_00851 - 0.16 0.17 0.17 7 4711 35 3 32 0 34
PDB_00917 - 0.31 0.34 0.29 32 35136 81 10 67 4 63
PDB_01009 0.27 0.33 0.23 7 2455 25 3 20 2 14
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0
TMR_00036 0.22 0.29 0.17 29 90359 153 37 100 16 72
TMR_00123 0.19 0.23 0.16 23 66283 126 20 104 2 78
TMR_00180 0.12 0.16 0.10 16 66999 149 35 111 3 83
TMR_00240 0.23 0.31 0.17 26 63041 128 39 84 5 59
TMR_00352 0.07 0.09 0.05 7 95133 171 39 87 45 68
TMR_00353 0.41 0.51 0.32 54 84087 127 49 65 13 51
TMR_00357 0.26 0.34 0.19 31 82869 146 44 84 18 61
TMR_00361 - 0.06 0.10 0.04 7 93368 174 64 89 21 65
TMR_00374 0.09 0.13 0.07 12 81631 174 44 123 7 80
TMR_00384 0.17 0.20 0.14 22 65550 133 26 105 2 86
TMR_00395 0.27 0.31 0.24 34 64478 115 10 98 7 75
TMR_00398 0.05 0.07 0.05 7 65197 139 24 113 2 99
TMR_00399 0.20 0.26 0.16 24 64833 130 38 85 7 70
TMR_00430 0.18 0.23 0.15 25 82450 148 34 112 2 84
TMR_00431 0.24 0.33 0.17 18 51899 127 26 60 41 37
TMR_00443 0.17 0.20 0.15 21 67018 126 24 98 4 83
TMR_00457 0.19 0.25 0.15 25 78443 141 39 99 3 77
TMR_00469 0.10 0.12 0.08 12 64469 145 27 112 6 88
TMR_00502 0.14 0.19 0.11 18 75303 150 45 100 5 75
TMR_00503 0.11 0.14 0.10 15 67741 141 20 120 1 96
TMR_00519 0.04 0.05 0.03 5 63046 141 33 106 2 90
TMR_00528 0.13 0.15 0.11 15 63051 131 20 104 7 82
TMR_00541 0.12 0.14 0.10 15 61630 139 22 109 8 90
TMR_00547 0.28 0.35 0.23 35 65188 122 37 81 4 65
TMR_00562 0.09 0.12 0.08 12 72617 147 27 115 5 90
TMR_00566 0.13 0.16 0.11 16 60582 132 22 106 4 84
TMR_00571 0.05 0.06 0.04 6 60577 149 19 124 6 93
TMR_00584 0.01 0.01 0.01 1 60922 159 33 119 7 96
TMR_00594 0.08 0.10 0.06 10 79238 156 30 123 3 94
TMR_00605 0.28 0.35 0.23 38 74141 129 36 90 3 70
TMR_00609 0.53 0.62 0.45 70 63391 89 28 57 4 43
TMR_00624 0.36 0.44 0.30 47 62325 111 27 82 2 61
TMR_00683 0.01 0.02 0.01 2 82854 176 50 122 4 98
TMR_00698 0.20 0.24 0.17 25 63042 124 27 96 1 79
TMR_00703 0.10 0.12 0.08 12 67376 140 26 114 0 87
TMR_00706 0.14 0.17 0.11 17 66281 133 29 103 1 86
TMR_00711 0.18 0.22 0.14 22 67740 137 41 93 3 76

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.