CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Carnac(seed)
MCC 0.776 > 0.552
Average MCC ± 95% Confidence Intervals 0.728 ± 0.204 > 0.182 ± 0.580
Sensitivity 0.752 > 0.327
Positive Predictive Value 0.800 < 0.932
Total TP 601 > 261
Total TN 1387035 < 1387506
Total FP 262 > 35
Total FP CONTRA 26 > 6
Total FP INCONS 124 > 13
Total FP COMP 112 > 16
Total FN 198 < 538
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Carnac(seed)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 601
Total TN 1387035
Total FP 262
Total FP CONTRA 26
Total FP INCONS 124
Total FP COMP 112
Total FN 198
Total Scores
MCC 0.776
Average MCC ± 95% Confidence Intervals 0.728 ± 0.204
Sensitivity 0.752
Positive Predictive Value 0.800
Nr of predictions 4

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00024 0.84 0.81 0.87 369 1085176 107 10 46 51 89
RFA_00599 0.55 0.52 0.58 58 101375 62 5 37 20 53
RFA_00601 0.81 0.80 0.81 91 99123 42 5 16 21 23
RFA_00602 0.72 0.72 0.73 83 101361 51 6 25 20 33

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 261
Total TN 1387506
Total FP 35
Total FP CONTRA 6
Total FP INCONS 13
Total FP COMP 16
Total FN 538
Total Scores
MCC 0.552
Average MCC ± 95% Confidence Intervals 0.182 ± 0.580
Sensitivity 0.327
Positive Predictive Value 0.932
Nr of predictions 4

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00024 0.73 0.57 0.93 261 1085321 35 6 13 16 197
RFA_00599 0.00 0.00 0.00 0 101475 0 0 0 0 111
RFA_00601 0.00 0.00 0.00 0 99235 0 0 0 0 114
RFA_00602 0.00 0.00 0.00 0 101475 0 0 0 0 116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.