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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Murlet(20)
MCC 0.655 > 0.566
Average MCC ± 95% Confidence Intervals 0.666 ± 0.024 > 0.550 ± 0.026
Sensitivity 0.557 > 0.437
Positive Predictive Value 0.770 > 0.734
Total TP 8501 > 6671
Total TN 16923140 < 16925088
Total FP 3306 > 2703
Total FP CONTRA 392 > 270
Total FP INCONS 2149 < 2153
Total FP COMP 765 > 280
Total FN 6754 < 8584
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(20)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 8501
Total TN 16923140
Total FP 3306
Total FP CONTRA 392
Total FP INCONS 2149
Total FP COMP 765
Total FN 6754
Total Scores
MCC 0.655
Average MCC ± 95% Confidence Intervals 0.666 ± 0.024
Sensitivity 0.557
Positive Predictive Value 0.770
Nr of predictions 118

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.52 0.41 0.65 40 47833 24 4 18 2 57
ASE_00007 0.82 0.75 0.90 83 59593 12 4 5 3 27
ASE_00018 0.77 0.64 0.91 86 80507 11 2 6 3 48
ASE_00022 0.66 0.58 0.75 72 82932 31 5 19 7 52
ASE_00028 0.69 0.60 0.78 76 84569 29 5 16 8 50
ASE_00035 0.75 0.66 0.86 78 70409 18 3 10 5 40
ASE_00040 0.69 0.59 0.80 78 78906 22 4 15 3 55
ASE_00064 0.82 0.71 0.94 63 45384 7 1 3 3 26
ASE_00068 0.67 0.52 0.88 44 37625 8 1 5 2 41
ASE_00075 0.49 0.35 0.69 56 108730 31 3 22 6 106
ASE_00077 0.77 0.70 0.85 60 45079 14 4 7 3 26
ASE_00078 0.79 0.72 0.87 60 43002 13 2 7 4 23
ASE_00080 0.37 0.30 0.47 37 71552 44 6 36 2 86
ASE_00081 0.76 0.67 0.87 65 49695 13 2 8 3 32
ASE_00082 0.35 0.24 0.50 28 70444 31 1 27 3 88
ASE_00083 0.71 0.56 0.89 62 62411 11 1 7 3 48
ASE_00084 0.71 0.59 0.85 58 53560 14 1 9 4 41
ASE_00087 0.31 0.21 0.46 30 88345 36 0 35 1 114
ASE_00092 0.56 0.43 0.73 49 63479 21 2 16 3 64
ASE_00104 0.82 0.73 0.93 87 64167 10 2 5 3 32
ASE_00107 0.78 0.68 0.91 86 73058 12 2 7 3 41
ASE_00115 0.54 0.43 0.68 43 54552 23 1 19 3 58
ASE_00119 0.30 0.24 0.38 26 62767 43 2 40 1 82
ASE_00123 0.67 0.53 0.85 45 38450 10 2 6 2 40
ASE_00135 0.40 0.32 0.51 35 63121 35 4 30 1 74
ASE_00138 0.73 0.63 0.85 51 40410 13 3 6 4 30
ASE_00142 0.79 0.70 0.89 86 67064 14 3 8 3 36
ASE_00146 0.78 0.66 0.92 82 70787 10 2 5 3 42
ASE_00153 0.60 0.48 0.76 35 57584 26 0 11 15 38
ASE_00163 0.79 0.70 0.89 65 53228 11 2 6 3 28
ASE_00170 0.71 0.62 0.82 58 48757 16 2 11 3 35
ASE_00174 0.54 0.42 0.69 46 61008 24 3 18 3 63
ASE_00179 0.57 0.49 0.66 41 44191 24 4 17 3 43
ASE_00180 0.72 0.61 0.85 61 51288 14 2 9 3 39
ASE_00182 0.35 0.24 0.51 33 84190 33 3 29 1 103
ASE_00184 0.69 0.55 0.86 56 54550 12 0 9 3 46
ASE_00185 0.23 0.16 0.32 21 73470 46 8 37 1 107
ASE_00186 0.72 0.62 0.84 82 78905 21 2 14 5 50
ASE_00190 0.53 0.42 0.67 38 45394 23 5 14 4 52
ASE_00212 0.67 0.54 0.82 80 93864 20 2 15 3 68
ASE_00214 0.74 0.63 0.87 65 56205 13 2 8 3 38
ASE_00215 0.38 0.26 0.54 26 48468 23 2 20 1 73
ASE_00217 0.81 0.71 0.93 64 40401 8 2 3 3 26
ASE_00221 0.78 0.69 0.89 81 64529 13 2 8 3 36
ASE_00228 0.62 0.51 0.76 44 46913 18 2 12 4 42
ASE_00229 0.72 0.62 0.84 54 42422 13 1 9 3 33
ASE_00238 0.54 0.39 0.76 44 64203 17 3 11 3 70
ASE_00241 0.80 0.72 0.89 63 43885 11 2 6 3 24
ASE_00248 0.81 0.72 0.92 82 62392 11 2 5 4 32
ASE_00255 0.61 0.50 0.74 65 74603 26 5 18 3 65
ASE_00257 0.72 0.58 0.90 56 50978 9 4 2 3 41
ASE_00267 0.75 0.65 0.86 57 45084 12 2 7 3 31
ASE_00270 0.39 0.27 0.56 35 72328 32 0 27 5 93
ASE_00279 0.78 0.65 0.93 66 53230 8 2 3 3 35
ASE_00280 0.73 0.62 0.85 61 51931 14 1 10 3 37
ASE_00281 0.79 0.68 0.91 60 44485 9 2 4 3 28
ASE_00283 0.68 0.56 0.82 60 61703 16 2 11 3 47
ASE_00285 0.51 0.40 0.64 49 68930 30 2 25 3 73
ASE_00292 0.77 0.65 0.92 90 81712 11 3 5 3 48
ASE_00294 0.67 0.51 0.87 88 114380 16 2 11 3 83
ASE_00297 0.62 0.50 0.77 49 52911 18 0 15 3 49
ASE_00298 0.55 0.42 0.72 47 67463 21 4 14 3 66
ASE_00318 0.63 0.54 0.74 64 80113 37 6 17 14 54
ASE_00328 0.73 0.66 0.80 74 72679 31 5 13 13 38
ASE_00332 0.74 0.63 0.88 87 81711 15 2 10 3 51
ASE_00335 0.72 0.66 0.78 76 75369 33 6 15 12 40
ASE_00340 0.51 0.45 0.59 38 45992 31 3 23 5 47
ASE_00353 0.69 0.56 0.86 60 57900 13 1 9 3 47
ASE_00361 0.66 0.46 0.94 59 75403 7 1 3 3 68
ASE_00362 0.76 0.66 0.88 60 48137 12 2 6 4 31
ASE_00363 0.77 0.63 0.94 59 51297 7 1 3 3 35
ASE_00364 0.70 0.57 0.87 60 54216 12 1 8 3 45
ASE_00366 0.58 0.48 0.70 47 58586 23 6 14 3 51
ASE_00367 0.79 0.71 0.88 61 43002 11 2 6 3 25
ASE_00372 0.57 0.45 0.71 45 51940 21 2 16 3 55
ASE_00376 0.65 0.55 0.76 58 56877 21 2 16 3 47
ASE_00382 0.79 0.71 0.88 60 41837 11 2 6 3 24
ASE_00384 0.72 0.61 0.85 56 48450 13 1 9 3 36
ASE_00386 0.75 0.61 0.92 59 50339 8 1 4 3 37
ASE_00387 0.60 0.50 0.71 52 55872 25 2 19 4 52
ASE_00388 0.74 0.64 0.85 57 45686 14 2 8 4 32
ASE_00390 0.78 0.68 0.89 58 42130 10 2 5 3 27
ASE_00393 0.68 0.57 0.82 53 47830 15 1 11 3 40
ASE_00394 0.73 0.62 0.87 58 46904 12 1 8 3 35
ASE_00395 0.82 0.71 0.94 60 41552 7 1 3 3 24
ASE_00396 0.75 0.66 0.85 55 41551 12 2 8 2 28
ASE_00397 0.74 0.61 0.90 64 54544 10 2 5 3 41
ASE_00398 0.65 0.52 0.82 54 55879 15 0 12 3 50
ASE_00400 0.45 0.37 0.56 39 57900 33 2 29 2 67
ASE_00402 0.83 0.74 0.94 63 42419 7 1 3 3 22
ASE_00404 0.78 0.67 0.90 57 43008 10 2 4 4 28
ASE_00406 0.79 0.68 0.93 64 48759 8 2 3 3 30
ASE_00411 0.59 0.48 0.72 43 49395 20 2 15 3 46
ASE_00412 0.55 0.42 0.72 44 58250 20 1 16 3 61
ASE_00416 0.69 0.60 0.80 76 77326 23 3 16 4 51
ASE_00419 0.59 0.49 0.72 50 54877 20 3 16 1 53
ASE_00422 0.58 0.49 0.69 46 46904 24 3 18 3 48
ASE_00423 0.81 0.72 0.90 79 56865 13 3 6 4 30
ASE_00428 0.69 0.60 0.80 75 76542 22 5 14 3 50
ASE_00430 0.55 0.45 0.68 44 46906 24 1 20 3 53
ASE_00437 0.58 0.50 0.69 67 79304 33 2 28 3 68
ASE_00448 0.80 0.72 0.88 81 64169 14 2 9 3 31
ASE_00451 0.77 0.66 0.88 83 70782 14 2 9 3 42
CRW_00177 0.68 0.61 0.77 287 1178505 117 12 76 29 186
CRW_00250 0.71 0.64 0.78 307 1198533 120 11 75 34 171
CRW_00278 0.68 0.60 0.78 271 1129907 113 9 69 35 179
CRW_00280 0.70 0.63 0.79 284 1117899 114 10 67 37 169
CRW_00411 0.49 0.47 0.52 231 1615062 273 41 169 63 265
CRW_00414 0.46 0.43 0.49 213 1665792 286 43 177 66 282
CRW_00789 0.71 0.63 0.80 280 1137437 111 7 62 42 167
PDB_00828 0.82 0.67 1.00 18 2467 0 0 0 0 9
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.81 0.74 0.89 25 4343 4 1 2 1 9
PDB_01105 0.66 0.55 0.80 299 1433595 117 1 76 40 241
RFA_00599 0.54 0.51 0.57 57 101375 62 5 38 19 54
RFA_00601 0.74 0.73 0.75 83 99124 49 4 24 21 31
RFA_00602 0.69 0.68 0.69 79 101361 50 5 30 15 37

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 6671
Total TN 16925088
Total FP 2703
Total FP CONTRA 270
Total FP INCONS 2153
Total FP COMP 280
Total FN 8584
Total Scores
MCC 0.566
Average MCC ± 95% Confidence Intervals 0.550 ± 0.026
Sensitivity 0.437
Positive Predictive Value 0.734
Nr of predictions 118

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.46 0.34 0.61 33 47841 21 1 20 0 64
ASE_00007 0.71 0.57 0.89 63 59614 8 2 6 0 47
ASE_00018 0.61 0.45 0.82 60 80528 13 3 10 0 74
ASE_00022 0.67 0.50 0.89 62 82958 15 0 8 7 62
ASE_00028 0.56 0.40 0.77 51 84600 15 5 10 0 75
ASE_00035 0.62 0.49 0.79 58 70427 17 4 11 2 60
ASE_00040 0.62 0.43 0.90 57 78940 6 0 6 0 76
ASE_00064 0.55 0.39 0.76 35 45405 14 3 8 3 54
ASE_00068 0.62 0.42 0.90 36 37635 4 3 1 0 49
ASE_00075 0.51 0.34 0.76 55 108739 19 1 16 2 107
ASE_00077 0.48 0.35 0.67 30 45105 18 0 15 3 56
ASE_00078 0.64 0.53 0.79 44 43015 12 3 9 0 39
ASE_00080 0.31 0.21 0.46 26 71574 31 3 28 0 97
ASE_00081 0.73 0.58 0.93 56 49710 5 0 4 1 41
ASE_00082 0.27 0.20 0.37 23 70438 42 2 37 3 93
ASE_00083 0.54 0.39 0.75 43 62424 14 2 12 0 67
ASE_00084 0.53 0.36 0.77 36 53581 12 0 11 1 63
ASE_00087 0.35 0.21 0.58 30 88358 22 0 22 0 114
ASE_00092 0.58 0.40 0.85 45 63493 10 0 8 2 68
ASE_00104 0.51 0.38 0.69 45 64196 20 1 19 0 74
ASE_00107 0.64 0.48 0.86 61 73082 13 2 8 3 66
ASE_00115 0.46 0.30 0.71 30 54573 12 1 11 0 71
ASE_00119 0.11 0.08 0.16 9 62779 48 2 45 1 99
ASE_00123 0.55 0.40 0.76 34 38458 11 0 11 0 51
ASE_00135 0.34 0.24 0.49 26 63137 29 3 24 2 83
ASE_00138 0.60 0.47 0.76 38 40420 13 0 12 1 43
ASE_00142 0.52 0.40 0.68 49 67089 23 1 22 0 73
ASE_00146 0.70 0.56 0.87 69 70797 13 0 10 3 55
ASE_00153 0.34 0.23 0.50 17 57596 26 3 14 9 56
ASE_00163 0.47 0.32 0.70 30 53258 13 0 13 0 63
ASE_00170 0.52 0.37 0.74 34 48782 12 0 12 0 59
ASE_00174 0.30 0.23 0.39 25 61011 43 2 37 4 84
ASE_00179 0.49 0.40 0.61 34 44197 22 0 22 0 50
ASE_00180 0.70 0.55 0.90 55 51299 6 2 4 0 45
ASE_00182 0.24 0.15 0.41 20 84206 31 1 28 2 116
ASE_00184 0.58 0.42 0.80 43 54561 11 2 9 0 59
ASE_00185 0.28 0.16 0.48 21 73492 23 0 23 0 107
ASE_00186 0.61 0.45 0.84 59 78933 11 1 10 0 73
ASE_00190 0.38 0.22 0.67 20 45421 12 0 10 2 70
ASE_00212 0.55 0.39 0.78 58 93887 16 1 15 0 90
ASE_00214 0.40 0.27 0.58 28 56232 21 1 19 1 75
ASE_00215 0.46 0.31 0.69 31 48471 14 4 10 0 68
ASE_00217 0.66 0.50 0.87 45 40418 7 1 6 0 45
ASE_00221 0.58 0.44 0.78 51 64555 14 0 14 0 66
ASE_00228 0.53 0.44 0.63 38 46911 23 1 21 1 48
ASE_00229 0.61 0.48 0.76 42 42431 13 3 10 0 45
ASE_00238 0.45 0.30 0.68 34 64211 16 2 14 0 80
ASE_00241 0.66 0.55 0.79 48 43895 16 2 11 3 39
ASE_00248 0.76 0.63 0.91 72 62402 7 0 7 0 42
ASE_00255 0.53 0.39 0.72 51 74620 21 1 19 1 79
ASE_00257 0.55 0.43 0.69 42 50979 19 0 19 0 55
ASE_00267 0.76 0.61 0.95 54 45093 4 2 1 1 34
ASE_00270 0.21 0.14 0.32 18 72333 41 0 39 2 110
ASE_00279 0.63 0.48 0.84 48 53244 9 1 8 0 53
ASE_00280 0.67 0.54 0.84 53 51940 10 3 7 0 45
ASE_00281 0.74 0.60 0.91 53 44493 5 0 5 0 35
ASE_00283 0.55 0.41 0.73 44 61716 16 0 16 0 63
ASE_00285 0.45 0.33 0.62 40 68941 25 1 24 0 82
ASE_00292 0.52 0.36 0.74 50 81742 18 1 17 0 88
ASE_00294 0.55 0.37 0.83 63 114405 14 4 9 1 108
ASE_00297 0.59 0.41 0.85 40 52928 10 0 7 3 58
ASE_00298 0.22 0.15 0.32 17 67475 36 4 32 0 96
ASE_00318 0.66 0.49 0.89 58 80135 16 2 5 9 60
ASE_00328 0.59 0.48 0.72 54 72696 27 5 16 6 58
ASE_00332 0.63 0.47 0.83 65 81732 13 2 11 0 73
ASE_00335 0.60 0.48 0.76 56 75392 19 5 13 1 60
ASE_00340 0.45 0.34 0.60 29 46008 22 3 16 3 56
ASE_00353 0.50 0.35 0.71 37 57918 15 0 15 0 70
ASE_00361 0.57 0.39 0.82 50 75405 11 1 10 0 77
ASE_00362 0.56 0.38 0.81 35 48162 12 0 8 4 56
ASE_00363 0.61 0.44 0.85 41 51312 7 0 7 0 53
ASE_00364 0.58 0.38 0.89 40 54240 5 0 5 0 65
ASE_00366 0.49 0.36 0.67 35 58601 19 0 17 2 63
ASE_00367 0.71 0.57 0.89 49 43016 6 2 4 0 37
ASE_00372 0.40 0.31 0.53 31 51944 28 3 25 0 69
ASE_00376 0.57 0.40 0.82 42 56902 9 2 7 0 63
ASE_00382 0.65 0.51 0.83 43 41853 9 2 7 0 41
ASE_00384 0.59 0.43 0.80 40 48466 10 2 8 0 52
ASE_00386 0.54 0.36 0.80 35 50359 9 1 8 0 61
ASE_00387 0.64 0.45 0.90 47 55893 5 0 5 0 57
ASE_00388 0.53 0.38 0.72 34 45706 16 1 12 3 55
ASE_00390 0.77 0.64 0.93 54 42137 6 1 3 2 31
ASE_00393 0.55 0.41 0.73 38 47843 15 3 11 1 55
ASE_00394 0.56 0.41 0.78 38 46922 11 1 10 0 55
ASE_00395 0.68 0.51 0.90 43 41568 5 0 5 0 41
ASE_00396 0.62 0.47 0.81 39 41568 9 0 9 0 44
ASE_00397 0.63 0.45 0.89 47 54562 9 1 5 3 58
ASE_00398 0.49 0.32 0.75 33 55901 12 0 11 1 71
ASE_00400 0.47 0.36 0.61 38 57908 25 3 21 1 68
ASE_00402 0.55 0.35 0.86 30 42451 5 2 3 0 55
ASE_00404 0.72 0.55 0.94 47 43021 4 0 3 1 38
ASE_00406 0.60 0.44 0.84 41 48779 8 0 8 0 53
ASE_00411 0.59 0.39 0.88 35 49415 5 0 5 0 54
ASE_00412 0.51 0.32 0.79 34 58268 11 0 9 2 71
ASE_00416 0.45 0.33 0.62 42 77353 26 1 25 0 85
ASE_00419 0.49 0.33 0.74 34 54900 12 2 10 0 69
ASE_00422 0.50 0.35 0.70 33 46924 14 0 14 0 61
ASE_00423 0.65 0.53 0.79 58 56880 15 0 15 0 51
ASE_00428 0.47 0.34 0.67 42 76573 21 4 17 0 83
ASE_00430 0.50 0.37 0.68 36 46918 17 0 17 0 61
ASE_00437 0.42 0.32 0.56 43 79324 34 3 31 0 92
ASE_00448 0.63 0.49 0.82 55 64194 12 3 9 0 57
ASE_00451 0.56 0.41 0.76 51 70809 16 1 15 0 74
CRW_00177 0.75 0.70 0.81 330 1178473 93 14 63 16 143
CRW_00250 0.75 0.68 0.84 325 1198537 73 14 50 9 153
CRW_00278 0.75 0.67 0.83 302 1129893 75 12 49 14 148
CRW_00280 0.78 0.72 0.85 328 1117874 75 11 47 17 125
CRW_00411 0.31 0.25 0.40 122 1615195 206 23 163 20 374
CRW_00414 0.33 0.29 0.36 146 1665818 288 38 223 27 349
CRW_00789 0.78 0.71 0.86 318 1137416 79 8 44 27 129
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19
PDB_01105 0.73 0.62 0.86 337 1433581 81 3 50 28 203
RFA_00599 0.44 0.34 0.58 38 101409 33 1 27 5 73
RFA_00601 0.31 0.23 0.42 26 99173 43 3 33 7 88
RFA_00602 0.24 0.16 0.35 19 101421 41 2 33 6 97

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.