CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MaxExpect		Carnac(seed)
MCC	0.533	>	0.253
Average MCC ± 95% Confidence Intervals	0.511 ± 0.049	>	0.107 ± 0.067
Sensitivity	0.524	>	0.068
Positive Predictive Value	0.543	<	0.940
Total TP	2785	>	362
Total TN	4544063	<	4548811
Total FP	3104	>	40
Total FP CONTRA	402	>	9
Total FP INCONS	1946	>	14
Total FP COMP	756	>	17
Total FN	2529	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MaxExpect and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP	2785
Total TN	4544063
Total FP	3104
Total FP CONTRA	402
Total FP INCONS	1946
Total FP COMP	756
Total FN	2529

Total Scores
MCC	0.533
Average MCC ± 95% Confidence Intervals	0.511 ± 0.049
Sensitivity	0.524
Positive Predictive Value	0.543
Nr of predictions	62

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.63	0.61	0.66	46	34121	30	2	22	6	29
ASE_00002	RNaseP_arch links to Rfam database...	0.71	0.67	0.74	49	35445	20	2	15	3	24
ASE_00009	RNaseP_arch links to Rfam database...	0.36	0.34	0.38	23	26045	39	4	34	1	44
ASE_00014	RNaseP_arch links to Rfam database...	0.42	0.42	0.44	44	54184	65	2	55	8	62
ASE_00116	RNaseP_arch links to Rfam database...	0.32	0.30	0.34	20	31567	42	4	35	3	46
ASE_00120	RNaseP_arch links to Rfam database...	0.59	0.54	0.65	51	46892	30	3	25	2	43
ASE_00121	RNaseP_arch links to Rfam database...	0.25	0.25	0.25	23	45059	70	6	62	2	69
ASE_00145	RNaseP_arch links to Rfam database...	0.58	0.57	0.59	63	70018	48	4	40	4	48
ASE_00148	RNaseP_arch links to Rfam database...	0.71	0.69	0.72	107	112427	45	3	38	4	47
ASE_00154	RNaseP_arch links to Rfam database...	0.58	0.58	0.58	62	65234	49	4	41	4	45
ASE_00155	RNaseP_arch links to Rfam database...	0.53	0.51	0.54	73	93394	64	10	51	3	69
ASE_00187	RNaseP_arch links to Rfam database...	0.40	0.38	0.43	44	68532	66	6	53	7	71
ASE_00196	RNaseP_arch links to Rfam database...	0.78	0.77	0.79	58	31553	19	2	13	4	17
ASE_00205	RNaseP_arch links to Rfam database...	0.62	0.62	0.62	56	45965	39	7	28	4	34
ASE_00209	RNaseP_arch links to Rfam database...	0.40	0.39	0.43	34	42991	46	5	41	0	54
ASE_00210	RNaseP_arch links to Rfam database...	0.65	0.66	0.64	43	27194	24	6	18	0	22
ASE_00213	RNaseP_arch links to Rfam database...	0.72	0.71	0.73	47	27197	20	3	14	3	19
ASE_00222	RNaseP_arch links to Rfam database...	0.58	0.56	0.60	88	111955	58	4	54	0	69
ASE_00346	RNaseP_arch links to Rfam database...	0.43	0.41	0.45	40	48117	56	4	44	8	57
ASE_00359	RNaseP_arch links to Rfam database...	0.25	0.24	0.26	19	42704	55	5	50	0	61
ASE_00360	RNaseP_arch links to Rfam database...	0.29	0.28	0.31	18	29344	46	9	32	5	47
ASE_00417	RNaseP_arch links to Rfam database...	0.36	0.37	0.35	37	54510	69	9	59	1	63
ASE_00418	RNaseP_arch links to Rfam database...	0.19	0.20	0.19	15	38702	67	8	56	3	60
CRW_00013	Intron_gpI links to Rfam database...	0.42	0.37	0.47	43	103648	69	4	45	20	72
CRW_00016	Intron_gpI links to Rfam database...	0.51	0.47	0.57	56	77322	56	6	37	13	64
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.71	0.70	0.71	320	1085152	169	17	112	40	138
CRW_00610	Intron_gpI links to Rfam database...	0.46	0.46	0.47	37	36237	41	7	34	0	44
CRW_00613	Intron_gpI links to Rfam database...	0.85	0.82	0.89	64	34908	16	0	8	8	14
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.16	0.12	9	121696	125	18	48	59	48
CRW_00618	Intron_gpI links to Rfam database...	0.19	0.20	0.19	12	56217	69	7	44	18	49
CRW_00619	Intron_gpI links to Rfam database...	0.36	0.37	0.35	27	164947	145	7	44	94	46
CRW_00620	Intron_gpI links to Rfam database...	0.18	0.21	0.15	13	150890	150	18	54	78	50
CRW_00621	Intron_gpI links to Rfam database...	0.38	0.35	0.42	25	153121	125	6	29	90	46
CRW_00623	Intron_gpI links to Rfam database...	0.32	0.29	0.35	24	129727	109	5	39	65	59
CRW_00633	Intron_gpI links to Rfam database...	0.62	0.57	0.67	60	63457	32	8	21	3	46
CRW_00634	Intron_gpI links to Rfam database...	0.48	0.47	0.49	44	64531	49	9	36	4	50
CRW_00670	Intron_gpI links to Rfam database...	0.56	0.58	0.56	69	70001	57	12	43	2	51
CRW_00671	Intron_gpI links to Rfam database...	0.80	0.76	0.85	89	62730	20	1	15	4	28
CRW_00672	Intron_gpI links to Rfam database...	0.78	0.77	0.78	86	72280	32	6	18	8	25
CRW_00674	Intron_gpI links to Rfam database...	0.63	0.61	0.64	76	83318	45	8	34	3	48
CRW_00676	Intron_gpI links to Rfam database...	0.60	0.60	0.60	69	93413	64	12	34	18	46
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.32	31	68537	80	17	50	13	59
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2678	24	1	22	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.91	53	26970	7	0	5	2	28
PDB_01092	glmS links to Rfam database...	0.75	0.63	0.89	33	10116	6	0	4	2	19
RFA_00597	Telomerase-vert links to Rfam database...	0.24	0.26	0.23	28	97782	106	20	73	13	81
RFA_00598	Telomerase-vert links to Rfam database...	0.66	0.63	0.68	64	84572	59	3	27	29	37
RFA_00599	Telomerase-vert links to Rfam database...	0.72	0.72	0.71	80	101363	56	10	22	24	31
RFA_00600	Telomerase-vert links to Rfam database...	0.62	0.69	0.55	69	120170	89	30	26	33	31
RFA_00601	Telomerase-vert links to Rfam database...	0.49	0.52	0.46	59	99108	82	28	40	14	55
RFA_00602	Telomerase-vert links to Rfam database...	0.66	0.68	0.64	79	101352	64	17	27	20	37
RFA_00632	HDV_ribozyme links to Rfam database...	0.34	0.36	0.33	10	4065	20	2	18	0	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.41	0.43	0.40	12	3975	18	2	16	0	16
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.47	0.44	0.50	8	1875	8	1	7	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1934	9	4	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	2002	7	0	4	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1938	5	2	3	0	8
RFA_00808	RydC links to Rfam database...	0.62	0.56	0.69	9	2003	4	0	4	0	7
RFA_00809	RydC links to Rfam database...	0.37	0.38	0.38	6	2129	10	1	9	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

2. Individual counts for MaxExpect [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]