CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	McQFold		CMfinder(seed)
MCC	0.526	>	0.363
Average MCC ± 95% Confidence Intervals	0.636 ± 0.107	>	0.399 ± 0.081
Sensitivity	0.510	>	0.184
Positive Predictive Value	0.544	<	0.716
Total TP	876	>	317
Total TN	1068977	<	1070143
Total FP	883	>	134
Total FP CONTRA	167	>	6
Total FP INCONS	566	>	120
Total FP COMP	150	>	8
Total FN	843	<	1402
P-value	5.19332990918e-08

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Performance plots

Comparison of performance of McQFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP	876
Total TN	1068977
Total FP	883
Total FP CONTRA	167
Total FP INCONS	566
Total FP COMP	150
Total FN	843

Total Scores
MCC	0.526
Average MCC ± 95% Confidence Intervals	0.636 ± 0.107
Sensitivity	0.510
Positive Predictive Value	0.544
Nr of predictions	26

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.10	0.10	0.11	11	103641	107	9	79	19	104
CRW_00016	Intron_gpI links to Rfam database...	0.66	0.61	0.72	73	77320	38	5	23	10	47
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.48	0.51	39	36239	38	6	31	1	42
CRW_00613	Intron_gpI links to Rfam database...	0.81	0.73	0.89	57	34916	15	0	7	8	21
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	132	26	51	55	52
CRW_00618	Intron_gpI links to Rfam database...	0.37	0.39	0.34	24	56210	60	15	31	14	37
CRW_00633	Intron_gpI links to Rfam database...	0.74	0.72	0.77	76	63447	26	8	15	3	30
CRW_00634	Intron_gpI links to Rfam database...	0.44	0.41	0.47	39	64537	48	18	26	4	55
CRW_00670	Intron_gpI links to Rfam database...	0.54	0.53	0.55	63	70011	53	6	45	2	57
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.59	0.74	69	62742	28	5	19	4	48
CRW_00672	Intron_gpI links to Rfam database...	0.52	0.50	0.56	55	72291	48	9	35	4	56
CRW_00674	Intron_gpI links to Rfam database...	0.43	0.42	0.44	52	83319	69	14	51	4	72
CRW_00676	Intron_gpI links to Rfam database...	0.30	0.30	0.31	35	93414	85	9	70	6	80
CRW_00692	Intron_gpI links to Rfam database...	0.26	0.27	0.25	24	68538	77	23	50	4	66
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.68	0.70	0.67	16	2677	9	0	8	1	7
PDB_00827	Intron_gpI links to Rfam database...	0.68	0.59	0.79	48	26967	15	0	13	2	33
PDB_01092	glmS links to Rfam database...	0.81	0.75	0.89	39	10109	6	1	4	1	13
RFA_00632	HDV_ribozyme links to Rfam database...	0.88	0.89	0.86	25	4066	4	3	1	0	3
RFA_00636	HDV_ribozyme links to Rfam database...	0.73	0.71	0.74	20	3978	7	5	2	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.85	0.94	0.77	17	1931	5	4	1	0	1
RFA_00770	Corona_pk3 links to Rfam database...	0.88	0.78	1.00	14	2002	4	0	0	4	4
RFA_00773	Corona_pk3 links to Rfam database...	0.97	1.00	0.95	18	1934	5	1	0	4	0
RFA_00779	Corona_pk3 links to Rfam database...	0.97	0.94	1.00	17	1936	0	0	0	0	1
RFA_00808	RydC links to Rfam database...	1.00	1.00	1.00	16	2000	0	0	0	0	0
RFA_00809	RydC links to Rfam database...	0.79	0.81	0.76	13	2128	4	0	4	0	3

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	317
Total TN	1070143
Total FP	134
Total FP CONTRA	6
Total FP INCONS	120
Total FP COMP	8
Total FN	1402

Total Scores
MCC	0.363
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081
Sensitivity	0.184
Positive Predictive Value	0.716
Nr of predictions	26

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

2. Individual counts for McQFold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]