CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Multilign(20)		RNASampler(20)
MCC	0.610	>	0.555
Average MCC ± 95% Confidence Intervals	0.627 ± 0.040	>	0.573 ± 0.041
Sensitivity	0.557	>	0.436
Positive Predictive Value	0.669	<	0.708
Total TP	2375	>	1861
Total TN	2710013	<	2710933
Total FP	1460	>	963
Total FP CONTRA	287	>	228
Total FP INCONS	886	>	539
Total FP COMP	287	>	196
Total FN	1889	<	2403
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Multilign(20) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and RNASampler(20)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP	2375
Total TN	2710013
Total FP	1460
Total FP CONTRA	287
Total FP INCONS	886
Total FP COMP	287
Total FN	1889

Total Scores
MCC	0.610
Average MCC ± 95% Confidence Intervals	0.627 ± 0.040
Sensitivity	0.557
Positive Predictive Value	0.669
Nr of predictions	47

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.76	0.67	0.86	60	45381	21	0	10	11	29
ASE_00090	RNaseP_bact_a links to Rfam database...	0.52	0.46	0.60	46	55534	36	5	26	5	55
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.49	0.60	53	63102	40	6	29	5	56
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.37	0.39	27	57560	76	9	34	33	46
ASE_00215	RNaseP_bact_a links to Rfam database...	0.18	0.15	0.23	15	48450	55	4	47	4	84
ASE_00328	RNaseP_bact_b links to Rfam database...	0.76	0.67	0.87	75	72685	23	1	10	12	37
ASE_00361	RNaseP_bact_a links to Rfam database...	0.58	0.49	0.69	62	75376	29	3	25	1	65
ASE_00441	RNaseP_bact_a links to Rfam database...	0.66	0.57	0.77	64	64178	19	2	17	0	48
PDB_00571	tRNA links to Rfam database...	0.85	0.76	0.95	19	3301	1	1	0	0	6
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	2	0	0	2	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	3	0	0	3	6
PDB_01073	SAM links to Rfam database...	0.86	0.74	1.00	25	4346	1	0	0	1	9
TMR_00017	tmRNA links to Rfam database...	0.59	0.56	0.62	57	67069	39	8	27	4	45
TMR_00018	tmRNA links to Rfam database...	0.59	0.54	0.65	50	64543	31	7	20	4	42
TMR_00042	tmRNA links to Rfam database...	0.61	0.57	0.65	56	62749	34	7	23	4	42
TMR_00046	tmRNA links to Rfam database...	0.65	0.63	0.67	60	62746	35	9	20	6	36
TMR_00048	tmRNA links to Rfam database...	0.59	0.55	0.63	52	64898	38	6	24	8	43
TMR_00080	tmRNA links to Rfam database...	0.51	0.46	0.56	44	70422	34	10	24	0	52
TMR_00082	tmRNA links to Rfam database...	0.65	0.59	0.71	57	67816	30	7	16	7	39
TMR_00123	tmRNA links to Rfam database...	0.64	0.59	0.68	60	66342	34	4	24	6	41
TMR_00137	tmRNA links to Rfam database...	0.33	0.28	0.38	25	61009	44	9	32	3	64
TMR_00142	tmRNA links to Rfam database...	0.62	0.64	0.61	65	70769	49	12	30	7	37
TMR_00207	tmRNA links to Rfam database...	0.40	0.35	0.45	36	72310	49	6	38	5	67
TMR_00257	tmRNA links to Rfam database...	0.68	0.61	0.76	60	67082	27	4	15	8	38
TMR_00271	tmRNA links to Rfam database...	0.64	0.56	0.74	51	64192	20	6	12	2	40
TMR_00366	tmRNA links to Rfam database...	0.64	0.60	0.67	60	67807	40	12	17	11	40
TMR_00378	tmRNA links to Rfam database...	0.67	0.63	0.71	61	67810	38	5	20	13	36
TMR_00404	tmRNA links to Rfam database...	0.59	0.59	0.60	54	67438	49	12	24	13	38
TMR_00427	tmRNA links to Rfam database...	0.53	0.41	0.69	40	67470	22	7	11	4	57
TMR_00443	tmRNA links to Rfam database...	0.67	0.59	0.77	61	67082	22	4	14	4	43
TMR_00451	tmRNA links to Rfam database...	0.52	0.45	0.60	40	63479	31	7	20	4	49
TMR_00458	tmRNA links to Rfam database...	0.70	0.63	0.77	59	63469	21	4	14	3	34
TMR_00469	tmRNA links to Rfam database...	0.75	0.73	0.78	73	64526	30	7	14	9	27
TMR_00472	tmRNA links to Rfam database...	0.76	0.73	0.80	71	64531	23	7	11	5	26
TMR_00519	tmRNA links to Rfam database...	0.60	0.57	0.64	54	63106	34	12	18	4	41
TMR_00520	tmRNA links to Rfam database...	0.67	0.62	0.73	61	63106	31	4	19	8	38
TMR_00522	tmRNA links to Rfam database...	0.53	0.47	0.60	46	63113	36	9	22	5	51
TMR_00528	tmRNA links to Rfam database...	0.51	0.45	0.58	44	63114	37	10	22	5	53
TMR_00568	tmRNA links to Rfam database...	0.62	0.59	0.65	58	60637	40	8	23	9	41
TMR_00571	tmRNA links to Rfam database...	0.69	0.65	0.73	64	60638	34	10	14	10	35
TMR_00580	tmRNA links to Rfam database...	0.62	0.61	0.63	61	60629	46	10	26	10	39
TMR_00584	tmRNA links to Rfam database...	0.65	0.61	0.69	59	60989	36	6	21	9	38
TMR_00586	tmRNA links to Rfam database...	0.60	0.59	0.61	57	60982	43	11	25	7	40
TMR_00616	tmRNA links to Rfam database...	0.65	0.63	0.68	62	67070	35	7	22	6	37
TMR_00699	tmRNA links to Rfam database...	0.69	0.60	0.80	61	67085	16	2	13	1	41
TMR_00702	tmRNA links to Rfam database...	0.63	0.54	0.73	54	67087	26	7	13	6	46

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1861
Total TN	2710933
Total FP	963
Total FP CONTRA	228
Total FP INCONS	539
Total FP COMP	196
Total FN	2403

Total Scores
MCC	0.555
Average MCC ± 95% Confidence Intervals	0.573 ± 0.041
Sensitivity	0.436
Positive Predictive Value	0.708
Nr of predictions	47

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.77	0.59	1.00	20	4351	1	0	0	1	14
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

2. Individual counts for Multilign(20) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]