CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Murlet(20)		RNASampler(20)
MCC	0.580	>	0.555
Average MCC ± 95% Confidence Intervals	0.588 ± 0.036	>	0.573 ± 0.040
Sensitivity	0.475	>	0.438
Positive Predictive Value	0.709	>	0.705
Total TP	2068	>	1906
Total TN	2798996	<	2799211
Total FP	1022	>	999
Total FP CONTRA	200	<	247
Total FP INCONS	650	>	550
Total FP COMP	172	<	202
Total FN	2285	<	2447
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Murlet(20) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNASampler(20)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP	2068
Total TN	2798996
Total FP	1022
Total FP CONTRA	200
Total FP INCONS	650
Total FP COMP	172
Total FN	2285

Total Scores
MCC	0.580
Average MCC ± 95% Confidence Intervals	0.588 ± 0.036
Sensitivity	0.475
Positive Predictive Value	0.709
Nr of predictions	48

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.55	0.39	0.76	35	45405	14	3	8	3	54
ASE_00135	RNaseP_bact_a links to Rfam database...	0.34	0.24	0.49	26	63137	29	3	24	2	83
ASE_00153	RNaseP_nuc links to Rfam database...	0.34	0.23	0.50	17	57596	26	3	14	9	56
ASE_00215	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	31	48471	14	4	10	0	68
ASE_00328	RNaseP_bact_b links to Rfam database...	0.59	0.48	0.72	54	72696	27	5	16	6	58
ASE_00361	RNaseP_bact_a links to Rfam database...	0.57	0.39	0.82	50	75405	11	1	10	0	77
PDB_00571	tRNA links to Rfam database...	0.59	0.52	0.68	13	3302	7	0	6	1	12
PDB_00828	Purine links to Rfam database...	0.84	0.70	1.00	19	2466	0	0	0	0	8
PDB_00829	Purine links to Rfam database...	0.82	0.67	1.00	16	2262	0	0	0	0	8
PDB_01020	Purine links to Rfam database...	0.83	0.70	1.00	16	2262	0	0	0	0	7
PDB_01073	SAM links to Rfam database...	0.66	0.44	1.00	15	4356	1	0	0	1	19
TMR_00017	tmRNA links to Rfam database...	0.72	0.60	0.87	61	67091	13	0	9	4	41
TMR_00018	tmRNA links to Rfam database...	0.56	0.49	0.65	45	64551	29	6	18	5	47
TMR_00042	tmRNA links to Rfam database...	0.56	0.44	0.70	43	62774	19	1	17	1	55
TMR_00046	tmRNA links to Rfam database...	0.60	0.52	0.69	50	62763	23	6	16	1	46
TMR_00048	tmRNA links to Rfam database...	0.56	0.48	0.66	46	64910	29	9	15	5	49
TMR_00080	tmRNA links to Rfam database...	0.54	0.49	0.60	47	70422	35	12	19	4	49
TMR_00082	tmRNA links to Rfam database...	0.59	0.50	0.71	48	67828	25	7	13	5	48
TMR_00123	tmRNA links to Rfam database...	0.64	0.50	0.81	51	66367	17	3	9	5	50
TMR_00137	tmRNA links to Rfam database...	0.54	0.46	0.64	41	61011	28	5	18	5	48
TMR_00142	tmRNA links to Rfam database...	0.64	0.60	0.69	61	70788	34	12	15	7	41
TMR_00207	tmRNA links to Rfam database...	0.53	0.42	0.66	43	72325	26	4	18	4	60
TMR_00257	tmRNA links to Rfam database...	0.56	0.48	0.64	47	67088	29	4	22	3	51
TMR_00271	tmRNA links to Rfam database...	0.55	0.42	0.72	38	64208	20	1	14	5	53
TMR_00332	tmRNA links to Rfam database...	0.70	0.58	0.85	57	67094	16	0	10	6	42
TMR_00366	tmRNA links to Rfam database...	0.53	0.49	0.58	49	67811	43	8	28	7	51
TMR_00378	tmRNA links to Rfam database...	0.57	0.51	0.64	49	67820	37	9	18	10	48
TMR_00404	tmRNA links to Rfam database...	0.53	0.41	0.68	38	67472	21	8	10	3	54
TMR_00427	tmRNA links to Rfam database...	0.20	0.13	0.30	13	67485	30	4	26	0	84
TMR_00443	tmRNA links to Rfam database...	0.73	0.61	0.88	63	67089	13	0	9	4	41
TMR_00451	tmRNA links to Rfam database...	0.52	0.46	0.58	41	63475	36	8	22	6	48
TMR_00458	tmRNA links to Rfam database...	0.50	0.41	0.61	38	63484	29	4	20	5	55
TMR_00469	tmRNA links to Rfam database...	0.64	0.48	0.84	48	64563	10	3	6	1	52
TMR_00472	tmRNA links to Rfam database...	0.70	0.61	0.81	59	64547	15	8	6	1	38
TMR_00519	tmRNA links to Rfam database...	0.49	0.37	0.65	35	63136	23	2	17	4	60
TMR_00520	tmRNA links to Rfam database...	0.44	0.35	0.54	35	63125	36	5	25	6	64
TMR_00522	tmRNA links to Rfam database...	0.49	0.39	0.60	38	63127	29	8	17	4	59
TMR_00528	tmRNA links to Rfam database...	0.48	0.41	0.57	40	63120	36	7	23	6	57
TMR_00540	tmRNA links to Rfam database...	0.53	0.45	0.63	47	73461	28	8	20	0	57
TMR_00568	tmRNA links to Rfam database...	0.72	0.64	0.82	63	60649	18	3	11	4	36
TMR_00571	tmRNA links to Rfam database...	0.76	0.67	0.86	66	60649	15	2	9	4	33
TMR_00580	tmRNA links to Rfam database...	0.75	0.66	0.86	66	60649	15	2	9	4	34
TMR_00584	tmRNA links to Rfam database...	0.71	0.62	0.81	60	61001	17	4	10	3	37
TMR_00586	tmRNA links to Rfam database...	0.71	0.63	0.79	61	60998	20	5	11	4	36
TMR_00616	tmRNA links to Rfam database...	0.67	0.58	0.79	57	67089	16	6	9	1	42
TMR_00699	tmRNA links to Rfam database...	0.57	0.43	0.75	44	67102	19	1	14	4	58
TMR_00702	tmRNA links to Rfam database...	0.54	0.43	0.68	43	67098	25	3	17	5	57
TMR_00703	tmRNA links to Rfam database...	0.58	0.45	0.75	45	67468	19	3	12	4	54

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1906
Total TN	2799211
Total FP	999
Total FP CONTRA	247
Total FP INCONS	550
Total FP COMP	202
Total FN	2447

Total Scores
MCC	0.555
Average MCC ± 95% Confidence Intervals	0.573 ± 0.040
Sensitivity	0.438
Positive Predictive Value	0.705
Nr of predictions	48

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.77	0.59	1.00	20	4351	1	0	0	1	14
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

2. Individual counts for Murlet(20) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]