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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of CMfinder(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & CMfinder(seed) [.zip] - may take several seconds...


Overview

Metric Murlet(seed) CMfinder(seed)
MCC 0.488 > 0.443
Average MCC ± 95% Confidence Intervals 0.467 ± 0.124 > 0.456 ± 0.186
Sensitivity 0.321 < 0.333
Positive Predictive Value 0.748 > 0.597
Total TP 80 < 83
Total TN 33829 > 33797
Total FP 29 < 57
Total FP CONTRA 0 < 3
Total FP INCONS 27 < 53
Total FP COMP 2 > 1
Total FN 169 > 166
P-value 2.18293266588e-07

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Performance plots


  1. Comparison of performance of Murlet(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and CMfinder(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and CMfinder(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and CMfinder(seed)).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 80
Total TN 33829
Total FP 29
Total FP CONTRA 0
Total FP INCONS 27
Total FP COMP 2
Total FN 169
Total Scores
MCC 0.488
Average MCC ± 95% Confidence Intervals 0.467 ± 0.124
Sensitivity 0.321
Positive Predictive Value 0.748
Nr of predictions 11

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP 83
Total TN 33797
Total FP 57
Total FP CONTRA 3
Total FP INCONS 53
Total FP COMP 1
Total FN 166
Total Scores
MCC 0.443
Average MCC ± 95% Confidence Intervals 0.456 ± 0.186
Sensitivity 0.333
Positive Predictive Value 0.597
Nr of predictions 11

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.47 0.36 0.63 5 938 3 0 3 0 9
PDB_00716 -0.01 0.00 0.00 0 2688 13 0 13 0 23
PDB_01092 0.38 0.21 0.69 11 10137 6 0 5 1 41
RFA_00632 0.27 0.25 0.29 7 4071 17 0 17 0 21
RFA_00636 0.71 0.64 0.78 18 3982 5 2 3 0 10
RFA_00769 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00770 0.71 0.50 1.00 9 2007 0 0 0 0 9
RFA_00773 0.00 0.00 0.00 0 1949 4 0 4 0 18
RFA_00779 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.41 0.38 0.46 6 2132 7 1 6 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.