CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of Fold - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & Fold [.zip] - may take several seconds...


Overview

Metric Murlet(seed) Fold
MCC 0.584 > 0.412
Average MCC ± 95% Confidence Intervals 0.476 ± 0.098 > 0.462 ± 0.145
Sensitivity 0.492 > 0.399
Positive Predictive Value 0.694 > 0.426
Total TP 354 > 287
Total TN 1015109 > 1014946
Total FP 180 < 412
Total FP CONTRA 6 < 53
Total FP INCONS 150 < 333
Total FP COMP 24 < 26
Total FN 365 < 432
P-value 1.96907987703e-08

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Performance plots


  1. Comparison of performance of Murlet(seed) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and Fold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and Fold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and Fold).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 354
Total TN 1015109
Total FP 180
Total FP CONTRA 6
Total FP INCONS 150
Total FP COMP 24
Total FN 365
Total Scores
MCC 0.584
Average MCC ± 95% Confidence Intervals 0.476 ± 0.098
Sensitivity 0.492
Positive Predictive Value 0.694
Nr of predictions 14

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01343 0.64 0.61 0.68 263 977515 145 6 117 22 171
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00767 0.47 0.33 0.67 6 1882 3 0 3 0 12
RFA_00768 0.41 0.28 0.63 5 1883 3 0 3 0 13
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10

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Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP 287
Total TN 1014946
Total FP 412
Total FP CONTRA 53
Total FP INCONS 333
Total FP COMP 26
Total FN 432
Total Scores
MCC 0.412
Average MCC ± 95% Confidence Intervals 0.462 ± 0.145
Sensitivity 0.399
Positive Predictive Value 0.426
Nr of predictions 14

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2. Individual counts for Fold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01343 0.37 0.36 0.38 158 977486 272 36 221 15 276
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00716 -0.01 0.00 0.00 0 2678 24 1 22 1 23
PDB_01092 0.73 0.63 0.85 33 10114 8 0 6 2 19
RFA_00632 0.39 0.39 0.39 11 4067 17 2 15 0 17
RFA_00636 0.42 0.43 0.43 12 3977 16 2 14 0 16
RFA_00767 0.44 0.44 0.44 8 1873 10 1 9 0 10
RFA_00768 0.45 0.44 0.47 8 1874 10 1 8 1 10
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.61 0.56 0.67 10 2001 8 0 5 3 8
RFA_00773 0.71 0.56 0.91 10 1942 3 1 0 2 8
RFA_00779 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 18 2 14 2 16
RFA_00809 0.37 0.38 0.38 6 2129 10 1 9 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.