CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of MaxExpect - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & MaxExpect [.zip] - may take several seconds...


Overview

Metric Murlet(seed) MaxExpect
MCC 0.584 > 0.426
Average MCC ± 95% Confidence Intervals 0.476 ± 0.098 < 0.513 ± 0.124
Sensitivity 0.492 > 0.408
Positive Predictive Value 0.694 > 0.446
Total TP 354 > 293
Total TN 1015109 > 1014962
Total FP 180 < 382
Total FP CONTRA 6 < 45
Total FP INCONS 150 < 319
Total FP COMP 24 > 18
Total FN 365 < 426
P-value 2.05281399871e-08

^top




Performance plots


  1. Comparison of performance of Murlet(seed) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and MaxExpect).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and MaxExpect).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and MaxExpect).

^top





Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 354
Total TN 1015109
Total FP 180
Total FP CONTRA 6
Total FP INCONS 150
Total FP COMP 24
Total FN 365
Total Scores
MCC 0.584
Average MCC ± 95% Confidence Intervals 0.476 ± 0.098
Sensitivity 0.492
Positive Predictive Value 0.694
Nr of predictions 14

^top



2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01343 0.64 0.61 0.68 263 977515 145 6 117 22 171
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00767 0.47 0.33 0.67 6 1882 3 0 3 0 12
RFA_00768 0.41 0.28 0.63 5 1883 3 0 3 0 13
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10

^top



Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 293
Total TN 1014962
Total FP 382
Total FP CONTRA 45
Total FP INCONS 319
Total FP COMP 18
Total FN 426
Total Scores
MCC 0.426
Average MCC ± 95% Confidence Intervals 0.513 ± 0.124
Sensitivity 0.408
Positive Predictive Value 0.446
Nr of predictions 14

^top



2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01343 0.37 0.35 0.38 154 977498 261 31 218 12 280
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00716 -0.01 0.00 0.00 0 2678 24 1 22 1 23
PDB_01092 0.75 0.63 0.89 33 10116 6 0 4 2 19
RFA_00632 0.34 0.36 0.33 10 4065 20 2 18 0 18
RFA_00636 0.41 0.43 0.40 12 3975 18 2 16 0 16
RFA_00767 0.63 0.56 0.71 10 1877 4 0 4 0 8
RFA_00768 0.47 0.44 0.50 8 1875 8 1 7 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 0.63 0.56 0.71 10 2002 7 0 4 3 8
RFA_00773 0.59 0.56 0.63 10 1937 6 1 5 0 8
RFA_00779 0.61 0.56 0.67 10 1938 5 2 3 0 8
RFA_00808 0.62 0.56 0.69 9 2003 4 0 4 0 7
RFA_00809 0.37 0.38 0.38 6 2129 10 1 9 0 10

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.