CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	NanoFolder		RSpredict(seed)
MCC	0.184	>	0.050
Average MCC ± 95% Confidence Intervals	0.202 ± 0.044	>	0.059 ± 0.036
Sensitivity	0.210	>	0.013
Positive Predictive Value	0.164	<	0.195
Total TP	1279	>	81
Total TN	3482322	<	3489695
Total FP	6672	>	368
Total FP CONTRA	922	>	31
Total FP INCONS	5588	>	304
Total FP COMP	162	>	33
Total FN	4812	<	6010
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of NanoFolder and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for NanoFolder and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and RSpredict(seed)).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	1279
Total TN	3482322
Total FP	6672
Total FP CONTRA	922
Total FP INCONS	5588
Total FP COMP	162
Total FN	4812

Total Scores
MCC	0.184
Average MCC ± 95% Confidence Intervals	0.202 ± 0.044
Sensitivity	0.210
Positive Predictive Value	0.164
Nr of predictions	60

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00017	RNaseP_nuc links to Rfam database...	0.02	0.03	0.02	2	50914	131	38	86	7	62
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00122	RNaseP_bact_a links to Rfam database...	0.27	0.30	0.24	26	43258	84	13	68	3	62
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00196	RNaseP_arch links to Rfam database...	0.49	0.57	0.42	43	31524	62	16	43	3	32
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00227	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	41	78840	122	20	102	0	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00231	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	40	47773	84	17	65	2	56
ASE_00234	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	35	75315	117	10	106	1	94
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00248	RNaseP_bact_a links to Rfam database...	0.13	0.15	0.12	17	62340	124	9	115	0	97
ASE_00250	RNaseP_bact_a links to Rfam database...	0.25	0.29	0.23	38	78835	135	17	113	5	93
ASE_00254	RNaseP_bact_a links to Rfam database...	0.15	0.16	0.14	13	36761	88	3	79	6	69
ASE_00255	RNaseP_bact_a links to Rfam database...	0.11	0.12	0.10	16	74530	146	16	129	1	114
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55487	126	12	112	2	103
ASE_00277	RNaseP_bact_a links to Rfam database...	0.10	0.12	0.08	11	48071	123	23	100	0	80
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00287	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	17	54824	107	14	91	2	86
ASE_00294	RNaseP_bact_a links to Rfam database...	0.12	0.13	0.12	23	114287	172	11	160	1	148
ASE_00295	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	21	73761	140	19	119	2	110
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00318	RNaseP_bact_b links to Rfam database...	0.03	0.04	0.03	5	80039	156	21	135	0	113
ASE_00335	RNaseP_bact_b links to Rfam database...	0.10	0.12	0.09	14	75304	151	22	126	3	102
ASE_00339	RNaseP_bact_a links to Rfam database...	0.25	0.29	0.22	34	80042	129	20	104	5	85
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00343	RNaseP_bact_a links to Rfam database...	0.14	0.17	0.12	19	83275	145	31	111	3	94
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00370	RNaseP_bact_a links to Rfam database...	0.03	0.04	0.03	3	41796	109	18	88	3	81
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00375	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	15	60246	120	10	107	3	95
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00377	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	29	57505	98	10	86	2	78
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00412	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	18	58183	111	14	96	1	87
ASE_00413	RNaseP_bact_a links to Rfam database...	0.08	0.10	0.07	8	44438	108	19	86	3	73
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00417	RNaseP_arch links to Rfam database...	0.32	0.36	0.28	36	54486	98	18	75	5	64
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00434	RNaseP_bact_b links to Rfam database...	0.29	0.34	0.25	37	68116	122	20	92	10	73
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.18	0.21	0.16	24	62682	130	23	106	1	93
CRW_00672	Intron_gpI links to Rfam database...	0.36	0.43	0.31	48	72233	114	35	74	5	63
CRW_00674	Intron_gpI links to Rfam database...	0.16	0.19	0.14	23	83274	142	19	120	3	101
CRW_00676	Intron_gpI links to Rfam database...	0.11	0.14	0.09	16	93347	169	29	136	4	99
PDB_00828	Purine links to Rfam database...	0.30	0.33	0.28	9	2453	23	0	23	0	18
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1996	24	0	20	4	18
RFA_00773	Corona_pk3 links to Rfam database...	0.93	1.00	0.86	18	1932	9	3	0	6	0
RFA_00808	RydC links to Rfam database...	0.83	1.00	0.70	16	1993	7	7	0	0	0
TMR_00357	tmRNA links to Rfam database...	0.26	0.34	0.19	31	82869	146	44	84	18	61

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	81
Total TN	3489695
Total FP	368
Total FP CONTRA	31
Total FP INCONS	304
Total FP COMP	33
Total FN	6010

Total Scores
MCC	0.050
Average MCC ± 95% Confidence Intervals	0.059 ± 0.036
Sensitivity	0.013
Positive Predictive Value	0.195
Nr of predictions	60

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00017	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	51038	2	0	2	0	64
ASE_00083	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	62477	5	0	4	1	110
ASE_00122	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	43360	6	0	5	1	88
ASE_00185	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	73531	5	0	5	0	128
ASE_00190	RNaseP_bact_b links to Rfam database...	0.00	0.00	0.00	0	45437	15	3	11	1	90
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00221	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	64617	3	0	3	0	117
ASE_00227	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	78993	10	3	7	0	133
ASE_00228	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	46967	4	0	4	0	86
ASE_00229	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	42482	4	1	3	0	87
ASE_00231	RNaseP_bact_a links to Rfam database...	0.07	0.02	0.22	2	47886	8	2	5	1	94
ASE_00234	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	75463	3	1	2	0	129
ASE_00238	RNaseP_bact_a links to Rfam database...	0.07	0.01	0.50	1	64259	1	0	1	0	113
ASE_00248	RNaseP_bact_a links to Rfam database...	0.11	0.03	0.43	3	62474	4	0	4	0	111
ASE_00250	RNaseP_bact_a links to Rfam database...	0.08	0.02	0.30	3	78993	7	0	7	0	128
ASE_00254	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	36850	6	1	5	0	82
ASE_00255	RNaseP_bact_a links to Rfam database...	0.12	0.03	0.50	4	74683	4	0	4	0	126
ASE_00257	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	51035	5	0	5	0	97
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45145	6	0	5	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	72388	3	0	2	1	128
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55608	3	0	3	0	103
ASE_00277	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	48203	2	0	2	0	91
ASE_00279	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	53299	2	0	2	0	101
ASE_00285	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	69000	6	0	6	0	122
ASE_00287	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	54939	7	0	7	0	103
ASE_00294	RNaseP_bact_a links to Rfam database...	0.08	0.02	0.31	4	114468	9	0	9	0	167
ASE_00295	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	73909	11	0	11	0	131
ASE_00298	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	67525	3	1	2	0	113
ASE_00318	RNaseP_bact_b links to Rfam database...	0.00	0.00	0.00	0	80184	21	0	16	5	118
ASE_00335	RNaseP_bact_b links to Rfam database...	0.00	0.00	0.00	0	75451	19	1	14	4	116
ASE_00339	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	80192	8	0	8	0	119
ASE_00340	RNaseP_bact_a links to Rfam database...	0.04	0.01	0.14	1	46049	6	0	6	0	84
ASE_00343	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	83429	8	1	6	1	113
ASE_00367	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	43067	5	0	4	1	86
ASE_00370	RNaseP_bact_a links to Rfam database...	0.10	0.02	0.40	2	41900	3	0	3	0	82
ASE_00372	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	51997	6	0	6	0	100
ASE_00375	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	60373	5	0	5	0	110
ASE_00376	RNaseP_bact_a links to Rfam database...	0.04	0.01	0.17	1	56947	5	0	5	0	104
ASE_00377	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	57628	2	0	2	0	107
ASE_00386	RNaseP_bact_a links to Rfam database...	0.10	0.03	0.33	3	50394	7	0	6	1	93
ASE_00393	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	47891	4	0	4	0	93
ASE_00412	RNaseP_bact_a links to Rfam database...	0.04	0.01	0.17	1	58305	5	1	4	0	104
ASE_00413	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	44546	5	0	5	0	81
ASE_00416	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	77412	9	0	9	0	127
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00422	RNaseP_bact_a links to Rfam database...	0.05	0.02	0.12	2	46954	19	1	14	4	92
ASE_00428	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	76629	8	0	7	1	125
ASE_00430	RNaseP_bact_a links to Rfam database...	0.07	0.02	0.25	2	46963	6	0	6	0	95
ASE_00434	RNaseP_bact_b links to Rfam database...	0.04	0.02	0.11	2	68246	20	1	16	3	108
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79395	7	0	6	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.11	0.03	0.36	4	70865	7	0	7	0	121
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72386	7	0	4	3	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	1	0	0	1	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93527	2	0	1	1	115
PDB_00828	Purine links to Rfam database...	0.54	0.41	0.73	11	2470	4	2	2	0	16
RFA_00770	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1997	9	6	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00808	RydC links to Rfam database...	0.60	0.50	0.73	8	2005	4	0	3	1	8
TMR_00357	tmRNA links to Rfam database...	0.25	0.09	0.73	8	83017	3	0	3	0	84

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]