CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(seed)		Carnac(seed)
MCC	0.654	>	0.253
Average MCC ± 95% Confidence Intervals	0.623 ± 0.042	>	0.107 ± 0.067
Sensitivity	0.534	>	0.068
Positive Predictive Value	0.802	<	0.940
Total TP	2839	>	362
Total TN	4545655	<	4548811
Total FP	976	>	40
Total FP CONTRA	140	>	9
Total FP INCONS	562	>	14
Total FP COMP	274	>	17
Total FN	2475	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	2839
Total TN	4545655
Total FP	976
Total FP CONTRA	140
Total FP INCONS	562
Total FP COMP	274
Total FN	2475

Total Scores
MCC	0.654
Average MCC ± 95% Confidence Intervals	0.623 ± 0.042
Sensitivity	0.534
Positive Predictive Value	0.802
Nr of predictions	62

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.68	0.57	0.80	43	34137	14	4	7	3	32
ASE_00002	RNaseP_arch links to Rfam database...	0.72	0.62	0.85	45	35458	13	3	5	5	28
ASE_00009	RNaseP_arch links to Rfam database...	0.79	0.75	0.85	50	26047	14	2	7	5	17
ASE_00014	RNaseP_arch links to Rfam database...	0.71	0.60	0.84	64	54209	16	3	9	4	42
ASE_00116	RNaseP_arch links to Rfam database...	0.77	0.71	0.84	47	31570	13	3	6	4	19
ASE_00120	RNaseP_arch links to Rfam database...	0.78	0.69	0.88	65	46897	14	3	6	5	29
ASE_00121	RNaseP_arch links to Rfam database...	0.76	0.68	0.84	63	45075	16	4	8	4	29
ASE_00145	RNaseP_arch links to Rfam database...	0.74	0.62	0.88	69	70047	13	3	6	4	42
ASE_00148	RNaseP_arch links to Rfam database...	0.59	0.42	0.84	64	112499	16	3	9	4	90
ASE_00154	RNaseP_arch links to Rfam database...	0.70	0.60	0.82	64	65263	18	3	11	4	43
ASE_00155	RNaseP_arch links to Rfam database...	0.66	0.49	0.88	69	93450	13	3	6	4	73
ASE_00187	RNaseP_arch links to Rfam database...	0.67	0.54	0.83	62	68560	17	4	9	4	53
ASE_00196	RNaseP_arch links to Rfam database...	0.74	0.69	0.80	52	31561	18	2	11	5	23
ASE_00205	RNaseP_arch links to Rfam database...	0.79	0.70	0.89	63	45985	13	4	4	5	27
ASE_00209	RNaseP_arch links to Rfam database...	0.81	0.75	0.88	66	42996	13	3	6	4	22
ASE_00210	RNaseP_arch links to Rfam database...	0.68	0.65	0.71	42	27202	24	2	15	7	23
ASE_00213	RNaseP_arch links to Rfam database...	0.78	0.74	0.83	49	27202	17	2	8	7	17
ASE_00222	RNaseP_arch links to Rfam database...	0.62	0.44	0.88	69	112023	13	3	6	4	88
ASE_00346	RNaseP_arch links to Rfam database...	0.60	0.53	0.68	51	48130	29	3	21	5	46
ASE_00359	RNaseP_arch links to Rfam database...	0.68	0.56	0.82	45	42723	15	3	7	5	35
ASE_00360	RNaseP_arch links to Rfam database...	0.78	0.72	0.84	47	29347	13	3	6	4	18
ASE_00417	RNaseP_arch links to Rfam database...	0.77	0.68	0.87	68	54537	14	3	7	4	32
ASE_00418	RNaseP_arch links to Rfam database...	0.71	0.61	0.82	46	38725	14	3	7	4	29
CRW_00013	Intron_gpI links to Rfam database...	0.41	0.25	0.66	29	103696	18	0	15	3	86
CRW_00016	Intron_gpI links to Rfam database...	0.40	0.24	0.66	29	77377	17	0	15	2	91
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.89	0.88	0.90	405	1085153	80	10	33	37	53
CRW_00610	Intron_gpI links to Rfam database...	0.54	0.38	0.76	31	36274	12	1	9	2	50
CRW_00613	Intron_gpI links to Rfam database...	0.40	0.29	0.55	23	34938	22	1	18	3	55
CRW_00614	Intron_gpI links to Rfam database...	0.49	0.39	0.63	22	121736	16	2	11	3	35
CRW_00618	Intron_gpI links to Rfam database...	0.38	0.28	0.52	17	56247	16	2	14	0	44
CRW_00619	Intron_gpI links to Rfam database...	0.46	0.29	0.72	21	164996	11	1	7	3	52
CRW_00620	Intron_gpI links to Rfam database...	0.36	0.25	0.52	16	150944	27	0	15	12	47
CRW_00621	Intron_gpI links to Rfam database...	0.35	0.25	0.49	18	153144	20	3	16	1	53
CRW_00623	Intron_gpI links to Rfam database...	0.43	0.28	0.68	23	129761	14	2	9	3	60
CRW_00633	Intron_gpI links to Rfam database...	0.38	0.24	0.61	25	63505	16	2	14	0	81
CRW_00634	Intron_gpI links to Rfam database...	0.31	0.19	0.50	18	64584	24	1	17	6	76
CRW_00670	Intron_gpI links to Rfam database...	0.51	0.31	0.84	37	70081	8	0	7	1	83
CRW_00671	Intron_gpI links to Rfam database...	0.52	0.32	0.84	37	62791	8	0	7	1	80
CRW_00672	Intron_gpI links to Rfam database...	0.52	0.32	0.84	36	72347	10	0	7	3	75
CRW_00674	Intron_gpI links to Rfam database...	0.25	0.15	0.45	18	83396	25	6	16	3	106
CRW_00676	Intron_gpI links to Rfam database...	0.29	0.16	0.53	18	93494	24	0	16	8	97
CRW_00692	Intron_gpI links to Rfam database...	0.32	0.20	0.53	18	68601	24	0	16	8	72
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.80	0.64	1.00	9	937	0	0	0	0	5
PDB_00716	HDV_ribozyme links to Rfam database...	0.68	0.57	0.81	13	2685	3	0	3	0	10
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.37	0.68	30	26984	14	2	12	0	51
PDB_01092	glmS links to Rfam database...	0.68	0.56	0.83	29	10118	8	0	6	2	23
RFA_00597	Telomerase-vert links to Rfam database...	0.75	0.72	0.80	78	97805	27	2	18	7	31
RFA_00598	Telomerase-vert links to Rfam database...	0.71	0.67	0.75	68	84575	39	2	21	16	33
RFA_00599	Telomerase-vert links to Rfam database...	0.88	0.86	0.90	95	101370	21	3	7	11	16
RFA_00600	Telomerase-vert links to Rfam database...	0.81	0.76	0.86	76	120207	25	2	10	13	24
RFA_00601	Telomerase-vert links to Rfam database...	0.87	0.84	0.89	96	99127	25	3	9	13	18
RFA_00602	Telomerase-vert links to Rfam database...	0.82	0.77	0.87	89	101373	22	3	10	9	27
RFA_00632	HDV_ribozyme links to Rfam database...	0.69	0.64	0.75	18	4071	6	2	4	0	10
RFA_00636	HDV_ribozyme links to Rfam database...	0.73	0.68	0.79	19	3981	5	2	3	0	9
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	3	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	3	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	2002	4	3	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00808	RydC links to Rfam database...	0.71	0.56	0.90	9	2006	1	1	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	4	0	4	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]