Table of contents:
- Overview
- Performance Plots
- Performance of PETfold_pre2.0(seed)
- scored higher in this pairwise comparison
- Performance of HotKnots
- scored lower in this pairwise comparison
- Compile and download dataset for PETfold_pre2.0(seed) & HotKnots [.zip] - may take several seconds...
Overview
| Metric |
PETfold_pre2.0(seed) |
|
HotKnots |
|---|
| MCC |
0.729 |
>
|
0.575 |
| Average MCC ± 95% Confidence Intervals |
0.718
±
0.056
|
>
|
0.580
±
0.184
|
| Sensitivity |
0.649 |
>
|
0.563 |
| Positive Predictive Value |
0.824 |
>
|
0.594 |
| Total TP |
285 |
>
|
247 |
| Total TN |
54590 |
>
|
54520 |
| Total FP |
70 |
<
|
181 |
| Total FP CONTRA |
33 |
>
|
24 |
| Total FP INCONS |
28 |
<
|
145 |
| Total FP COMP |
9 |
<
|
12 |
| Total FN |
154 |
<
|
192 |
| P-value |
2.41358941668e-08 |
Performance plots
-
Comparison of performance of PETfold_pre2.0(seed) and HotKnots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data
(individual counts for PETfold_pre2.0(seed)
and HotKnots).
-
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data
(individual counts for PETfold_pre2.0(seed)
and HotKnots).
-
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and HotKnots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data
(individual counts for PETfold_pre2.0(seed)
and HotKnots).
Performance of PETfold_pre2.0(seed)
- scored higher in this pairwise comparison
1. Total counts & total scores for PETfold_pre2.0(seed)
| Total Base Pair Counts |
|---|
| Total TP |
285 |
| Total TN |
54590 |
| Total FP |
70 |
| Total FP CONTRA |
33 |
| Total FP INCONS |
28 |
| Total FP COMP |
9 |
| Total FN |
154 |
| Total Scores |
|---|
| MCC |
0.729 |
| Average MCC ± 95% Confidence Intervals |
0.718
±
0.056
|
| Sensitivity |
0.649 |
| Positive Predictive Value |
0.824 |
| Nr of predictions |
19 |
Performance of HotKnots
- scored lower in this pairwise comparison
1. Total counts & total scores for HotKnots
| Total Base Pair Counts |
|---|
| Total TP |
247 |
| Total TN |
54520 |
| Total FP |
181 |
| Total FP CONTRA |
24 |
| Total FP INCONS |
145 |
| Total FP COMP |
12 |
| Total FN |
192 |
| Total Scores |
|---|
| MCC |
0.575 |
| Average MCC ± 95% Confidence Intervals |
0.580
±
0.184
|
| Sensitivity |
0.563 |
| Positive Predictive Value |
0.594 |
| Nr of predictions |
19 |
Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based
on the paper by Gardener & Giegerich, 2004.
| 
