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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric PPfold(seed) NanoFolder
MCC 0.698 > 0.585
Average MCC ± 95% Confidence Intervals 0.702 ± 0.101 > 0.583 ± 1.279
Sensitivity 0.558 < 0.654
Positive Predictive Value 0.879 > 0.531
Total TP 29 < 34
Total TN 5952 > 5921
Total FP 4 < 40
Total FP CONTRA 2 < 10
Total FP INCONS 2 < 20
Total FP COMP 0 < 10
Total FN 23 > 18
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and NanoFolder).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 29
Total TN 5952
Total FP 4
Total FP CONTRA 2
Total FP INCONS 2
Total FP COMP 0
Total FN 23
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.702 ± 0.101
Sensitivity 0.558
Positive Predictive Value 0.879
Nr of predictions 3

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00770 0.68 0.56 0.83 10 2004 2 1 1 0 8
RFA_00773 0.68 0.56 0.83 10 1941 2 1 1 0 8
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 34
Total TN 5921
Total FP 40
Total FP CONTRA 10
Total FP INCONS 20
Total FP COMP 10
Total FN 18
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.583 ± 1.279
Sensitivity 0.654
Positive Predictive Value 0.531
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.