CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	PknotsRG		CMfinder(seed)
MCC	0.544	>	0.363
Average MCC ± 95% Confidence Intervals	0.629 ± 0.121	>	0.399 ± 0.081
Sensitivity	0.551	>	0.184
Positive Predictive Value	0.539	<	0.716
Total TP	947	>	317
Total TN	1068828	<	1070143
Total FP	980	>	134
Total FP CONTRA	184	>	6
Total FP INCONS	627	>	120
Total FP COMP	169	>	8
Total FN	772	<	1402
P-value	5.19332990918e-08

^top

Performance plots

Comparison of performance of PknotsRG and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).

^top

Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP	947
Total TN	1068828
Total FP	980
Total FP CONTRA	184
Total FP INCONS	627
Total FP COMP	169
Total FN	772

Total Scores
MCC	0.544
Average MCC ± 95% Confidence Intervals	0.629 ± 0.121
Sensitivity	0.551
Positive Predictive Value	0.539
Nr of predictions	26

^top

2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.16	0.17	0.15	19	103617	114	25	79	10	96
CRW_00016	Intron_gpI links to Rfam database...	0.64	0.62	0.66	74	77309	50	5	33	12	46
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.49	0.49	40	36233	43	7	35	1	41
CRW_00613	Intron_gpI links to Rfam database...	0.64	0.59	0.69	46	34913	29	1	20	8	32
CRW_00614	Intron_gpI links to Rfam database...	0.09	0.11	0.07	6	121690	145	21	54	70	51
CRW_00618	Intron_gpI links to Rfam database...	0.11	0.11	0.10	7	56211	83	13	49	21	54
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.48	0.52	51	63447	50	10	38	2	55
CRW_00634	Intron_gpI links to Rfam database...	0.56	0.60	0.52	56	64513	53	17	34	2	38
CRW_00670	Intron_gpI links to Rfam database...	0.75	0.74	0.77	89	70009	30	5	22	3	31
CRW_00671	Intron_gpI links to Rfam database...	0.77	0.76	0.78	89	62721	30	6	19	5	28
CRW_00672	Intron_gpI links to Rfam database...	0.53	0.55	0.52	61	72273	60	21	35	4	50
CRW_00674	Intron_gpI links to Rfam database...	0.52	0.52	0.52	65	83310	63	12	49	2	59
CRW_00676	Intron_gpI links to Rfam database...	0.56	0.60	0.52	69	93396	67	13	50	4	46
CRW_00692	Intron_gpI links to Rfam database...	0.43	0.46	0.41	41	68536	66	18	40	8	49
PDB_00005	Tymo_tRNA-like links to Rfam database...	1.00	1.00	1.00	14	932	0	0	0	0	0
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2675	27	1	25	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.46	0.55	37	26961	31	1	29	1	44
PDB_01092	glmS links to Rfam database...	0.71	0.67	0.74	35	10106	13	2	10	1	17
RFA_00632	HDV_ribozyme links to Rfam database...	0.88	0.89	0.86	25	4066	6	2	2	2	3
RFA_00636	HDV_ribozyme links to Rfam database...	0.95	0.96	0.93	27	3976	4	2	0	2	1
RFA_00769	Corona_pk3 links to Rfam database...	0.97	1.00	0.95	18	1934	3	1	0	2	0
RFA_00770	Corona_pk3 links to Rfam database...	0.88	0.78	1.00	14	2002	3	0	0	3	4
RFA_00773	Corona_pk3 links to Rfam database...	0.97	1.00	0.95	18	1934	4	1	0	3	0
RFA_00779	Corona_pk3 links to Rfam database...	0.97	0.94	1.00	17	1936	2	0	0	2	1
RFA_00808	RydC links to Rfam database...	1.00	1.00	1.00	16	2000	0	0	0	0	0
RFA_00809	RydC links to Rfam database...	0.79	0.81	0.76	13	2128	4	0	4	0	3

^top

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	317
Total TN	1070143
Total FP	134
Total FP CONTRA	6
Total FP INCONS	120
Total FP COMP	8
Total FN	1402

Total Scores
MCC	0.363
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081
Sensitivity	0.184
Positive Predictive Value	0.716
Nr of predictions	26

^top

2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

2. Individual counts for PknotsRG [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]