CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	ProbKnot		Carnac(seed)
MCC	0.529	>	0.253
Average MCC ± 95% Confidence Intervals	0.507 ± 0.048	>	0.107 ± 0.067
Sensitivity	0.523	>	0.068
Positive Predictive Value	0.535	<	0.940
Total TP	2781	>	362
Total TN	4544002	<	4548811
Total FP	3245	>	40
Total FP CONTRA	457	>	9
Total FP INCONS	1956	>	14
Total FP COMP	832	>	17
Total FN	2533	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of ProbKnot and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ProbKnot and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ProbKnot and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for ProbKnot and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ProbKnot and Carnac(seed)).

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Performance of ProbKnot - scored higher in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP	2781
Total TN	4544002
Total FP	3245
Total FP CONTRA	457
Total FP INCONS	1956
Total FP COMP	832
Total FN	2533

Total Scores
MCC	0.529
Average MCC ± 95% Confidence Intervals	0.507 ± 0.048
Sensitivity	0.523
Positive Predictive Value	0.535
Nr of predictions	62

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.63	0.61	0.65	46	34120	32	4	21	7	29
ASE_00002	RNaseP_arch links to Rfam database...	0.69	0.67	0.71	49	35442	28	4	16	8	24
ASE_00009	RNaseP_arch links to Rfam database...	0.38	0.37	0.40	25	26043	38	5	33	0	42
ASE_00014	RNaseP_arch links to Rfam database...	0.44	0.42	0.46	44	54190	57	2	49	6	62
ASE_00116	RNaseP_arch links to Rfam database...	0.39	0.36	0.43	24	31570	35	4	28	3	42
ASE_00120	RNaseP_arch links to Rfam database...	0.57	0.55	0.60	52	46884	35	7	28	0	42
ASE_00121	RNaseP_arch links to Rfam database...	0.25	0.25	0.26	23	45061	68	5	61	2	69
ASE_00145	RNaseP_arch links to Rfam database...	0.55	0.54	0.57	60	70019	51	7	39	5	51
ASE_00148	RNaseP_arch links to Rfam database...	0.69	0.66	0.73	101	112437	39	4	33	2	53
ASE_00154	RNaseP_arch links to Rfam database...	0.58	0.57	0.59	61	65237	46	4	39	3	46
ASE_00155	RNaseP_arch links to Rfam database...	0.54	0.52	0.56	74	93395	62	10	49	3	68
ASE_00187	RNaseP_arch links to Rfam database...	0.41	0.39	0.43	45	68531	66	7	52	7	70
ASE_00196	RNaseP_arch links to Rfam database...	0.79	0.79	0.79	59	31551	23	2	14	7	16
ASE_00205	RNaseP_arch links to Rfam database...	0.62	0.62	0.62	56	45965	39	6	29	4	34
ASE_00209	RNaseP_arch links to Rfam database...	0.43	0.40	0.46	35	42995	41	6	35	0	53
ASE_00210	RNaseP_arch links to Rfam database...	0.64	0.66	0.62	43	27192	28	6	20	2	22
ASE_00213	RNaseP_arch links to Rfam database...	0.71	0.70	0.73	46	27198	19	3	14	2	20
ASE_00222	RNaseP_arch links to Rfam database...	0.55	0.51	0.59	80	111965	58	5	51	2	77
ASE_00346	RNaseP_arch links to Rfam database...	0.46	0.44	0.48	43	48115	54	4	43	7	54
ASE_00359	RNaseP_arch links to Rfam database...	0.24	0.24	0.24	19	42698	61	7	54	0	61
ASE_00360	RNaseP_arch links to Rfam database...	0.32	0.31	0.33	20	29343	40	8	32	0	45
ASE_00417	RNaseP_arch links to Rfam database...	0.36	0.37	0.35	37	54509	72	11	58	3	63
ASE_00418	RNaseP_arch links to Rfam database...	0.19	0.20	0.19	15	38700	70	8	58	4	60
CRW_00013	Intron_gpI links to Rfam database...	0.39	0.37	0.42	43	103637	84	9	51	24	72
CRW_00016	Intron_gpI links to Rfam database...	0.48	0.45	0.50	54	77314	68	6	47	15	66
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.69	0.68	0.70	312	1085154	184	22	113	49	146
CRW_00610	Intron_gpI links to Rfam database...	0.44	0.44	0.43	36	36232	49	8	39	2	45
CRW_00613	Intron_gpI links to Rfam database...	0.84	0.82	0.86	64	34906	18	0	10	8	14
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.16	0.12	9	121698	120	17	47	56	48
CRW_00618	Intron_gpI links to Rfam database...	0.18	0.20	0.16	12	56207	83	15	46	22	49
CRW_00619	Intron_gpI links to Rfam database...	0.35	0.37	0.33	27	164943	151	8	47	96	46
CRW_00620	Intron_gpI links to Rfam database...	0.18	0.21	0.15	13	150891	156	19	52	85	50
CRW_00621	Intron_gpI links to Rfam database...	0.35	0.34	0.36	24	153114	139	8	35	96	47
CRW_00623	Intron_gpI links to Rfam database...	0.31	0.29	0.32	24	129721	122	7	43	72	59
CRW_00633	Intron_gpI links to Rfam database...	0.62	0.59	0.65	63	63449	38	9	25	4	43
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.49	0.52	46	64531	48	10	33	5	48
CRW_00670	Intron_gpI links to Rfam database...	0.57	0.58	0.56	70	70001	57	11	43	3	50
CRW_00671	Intron_gpI links to Rfam database...	0.79	0.77	0.80	90	62723	28	6	16	6	27
CRW_00672	Intron_gpI links to Rfam database...	0.76	0.78	0.74	87	72272	41	10	21	10	24
CRW_00674	Intron_gpI links to Rfam database...	0.68	0.67	0.70	83	83317	41	8	28	5	41
CRW_00676	Intron_gpI links to Rfam database...	0.59	0.58	0.60	67	93416	63	8	37	18	48
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.32	31	68537	84	18	49	17	59
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.78	0.79	0.79	11	932	3	0	3	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2680	22	0	21	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.76	0.67	0.86	54	26965	11	1	8	2	27
PDB_01092	glmS links to Rfam database...	0.73	0.63	0.85	33	10114	8	1	5	2	19
RFA_00597	Telomerase-vert links to Rfam database...	0.24	0.26	0.23	28	97782	111	22	71	18	81
RFA_00598	Telomerase-vert links to Rfam database...	0.62	0.58	0.66	59	84577	56	4	26	26	42
RFA_00599	Telomerase-vert links to Rfam database...	0.73	0.72	0.73	80	101366	58	10	19	29	31
RFA_00600	Telomerase-vert links to Rfam database...	0.62	0.70	0.55	70	120168	100	31	26	43	30
RFA_00601	Telomerase-vert links to Rfam database...	0.49	0.51	0.46	58	99110	84	27	40	17	56
RFA_00602	Telomerase-vert links to Rfam database...	0.66	0.68	0.65	79	101353	63	21	22	20	37
RFA_00632	HDV_ribozyme links to Rfam database...	0.40	0.39	0.41	11	4068	16	0	16	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.44	0.46	0.43	13	3975	17	0	17	0	15
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.44	0.44	0.44	8	1873	11	1	9	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1934	9	4	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	2000	9	0	6	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00808	RydC links to Rfam database...	0.65	0.56	0.75	9	2004	3	0	3	0	7
RFA_00809	RydC links to Rfam database...	0.35	0.38	0.33	6	2127	12	1	11	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of ProbKnot - scored higher in this pairwise comparison

1. Total counts & total scores for ProbKnot

2. Individual counts for ProbKnot [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]