CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ProbKnot - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for ProbKnot & NanoFolder [.zip] - may take several seconds...


Overview

Metric ProbKnot NanoFolder
MCC 0.548 > 0.174
Average MCC ± 95% Confidence Intervals 0.547 ± 0.034 > 0.183 ± 0.028
Sensitivity 0.540 > 0.207
Positive Predictive Value 0.558 > 0.149
Total TP 5898 > 2258
Total TN 6809909 > 6805326
Total FP 5552 < 13384
Total FP CONTRA 910 < 2402
Total FP INCONS 3768 < 10499
Total FP COMP 874 > 483
Total FN 5034 < 8674
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of ProbKnot and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ProbKnot and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ProbKnot and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for ProbKnot and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ProbKnot and NanoFolder).

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Performance of ProbKnot - scored higher in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 5898
Total TN 6809909
Total FP 5552
Total FP CONTRA 910
Total FP INCONS 3768
Total FP COMP 874
Total FN 5034
Total Scores
MCC 0.548
Average MCC ± 95% Confidence Intervals 0.547 ± 0.034
Sensitivity 0.540
Positive Predictive Value 0.558
Nr of predictions 112

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.17 0.20 0.15 13 50951 92 28 48 16 51
ASE_00083 0.68 0.66 0.70 73 62377 38 8 23 7 37
ASE_00122 0.69 0.64 0.76 56 43291 18 0 18 0 32
ASE_00185 0.76 0.72 0.81 92 73422 29 1 21 7 36
ASE_00190 0.62 0.61 0.63 55 45364 35 4 28 3 35
ASE_00196 0.79 0.79 0.79 59 31551 23 2 14 7 16
ASE_00221 0.65 0.56 0.75 66 64532 28 0 22 6 51
ASE_00227 0.55 0.54 0.56 72 78875 56 7 49 0 61
ASE_00228 0.57 0.55 0.59 47 46892 33 9 23 1 39
ASE_00229 0.69 0.66 0.72 57 42407 29 4 18 7 30
ASE_00231 0.62 0.60 0.63 58 47803 38 6 28 4 38
ASE_00234 0.59 0.55 0.63 71 75354 48 3 38 7 58
ASE_00238 0.72 0.65 0.80 74 64168 26 2 17 7 40
ASE_00248 0.40 0.37 0.44 42 62386 55 4 49 2 72
ASE_00250 0.62 0.59 0.66 77 78887 44 8 31 5 54
ASE_00254 0.37 0.33 0.42 27 36792 44 3 34 7 55
ASE_00255 0.55 0.54 0.56 70 74565 59 5 51 3 60
ASE_00257 0.66 0.63 0.70 61 50953 33 1 25 7 36
ASE_00267 0.64 0.59 0.69 52 45075 34 4 19 11 36
ASE_00270 0.80 0.79 0.82 101 72267 29 1 21 7 27
ASE_00274 0.64 0.56 0.73 58 55531 25 5 17 3 45
ASE_00277 0.44 0.44 0.44 40 48114 53 9 42 2 51
ASE_00279 0.50 0.49 0.52 49 53206 50 6 40 4 52
ASE_00285 0.78 0.71 0.85 87 68904 26 4 11 11 35
ASE_00287 0.73 0.70 0.76 72 54851 26 3 20 3 31
ASE_00294 0.75 0.67 0.85 115 114345 27 2 19 6 56
ASE_00295 0.61 0.60 0.62 78 73795 50 7 40 3 53
ASE_00298 0.50 0.48 0.52 54 67424 55 2 48 5 59
ASE_00318 0.63 0.64 0.63 75 80081 49 15 29 5 43
ASE_00335 0.60 0.59 0.61 69 75353 49 8 36 5 47
ASE_00339 0.67 0.61 0.74 72 80103 34 1 24 9 47
ASE_00340 0.72 0.72 0.72 61 45971 30 7 17 6 24
ASE_00343 0.70 0.69 0.71 78 83326 45 7 25 13 35
ASE_00367 0.57 0.55 0.60 47 42993 40 5 26 9 39
ASE_00370 0.73 0.70 0.77 59 41828 26 1 17 8 25
ASE_00372 0.67 0.65 0.68 65 51908 37 7 23 7 35
ASE_00375 0.82 0.77 0.87 85 60280 22 1 12 9 25
ASE_00376 0.65 0.65 0.65 68 56849 41 5 31 5 37
ASE_00377 0.75 0.74 0.76 79 57526 35 4 21 10 28
ASE_00386 0.54 0.54 0.54 52 50307 48 7 37 4 44
ASE_00393 0.47 0.42 0.53 39 47821 43 2 33 8 54
ASE_00412 0.49 0.48 0.52 50 58214 51 8 39 4 55
ASE_00413 0.64 0.67 0.62 54 44464 34 11 22 1 27
ASE_00416 0.70 0.67 0.73 85 77305 41 2 29 10 42
ASE_00417 0.36 0.37 0.35 37 54509 72 11 58 3 63
ASE_00422 0.79 0.77 0.81 72 46882 24 3 14 7 22
ASE_00428 0.78 0.75 0.82 94 76521 29 4 17 8 31
ASE_00429 - 0.56 0.52 0.61 34 28147 31 0 22 9 32
ASE_00430 0.77 0.74 0.81 72 46882 24 3 14 7 25
ASE_00434 0.62 0.61 0.64 67 68160 49 5 33 11 43
ASE_00437 0.43 0.41 0.47 55 79283 69 1 62 6 80
ASE_00451 0.62 0.60 0.65 75 70760 48 3 38 7 50
CRW_00648 - 0.61 0.61 0.61 90 137927 63 15 43 5 58
CRW_00654 - 0.68 0.68 0.69 84 78088 44 4 34 6 40
CRW_00658 - 0.49 0.50 0.48 51 74584 60 19 37 4 51
CRW_00663 - 0.00 0.00 0.00 0 26032 75 12 62 1 61
CRW_00664 - 0.21 0.24 0.19 19 53529 80 24 56 0 59
CRW_00671 0.79 0.77 0.80 90 62723 28 6 16 6 27
CRW_00672 0.76 0.78 0.74 87 72272 41 10 21 10 24
CRW_00674 0.68 0.67 0.70 83 83317 41 8 28 5 41
CRW_00676 0.59 0.58 0.60 67 93416 63 8 37 18 48
CRW_00685 - 0.37 0.40 0.35 42 156960 118 16 62 40 64
CRW_00688 - 0.87 0.86 0.89 49 21890 13 0 6 7 8
CRW_00721 - 0.60 0.63 0.57 43 58577 62 10 23 29 25
PDB_00078 - 0.74 0.70 0.78 80 49668 24 6 16 2 35
PDB_00278 - 0.14 0.14 0.14 10 24904 62 6 56 0 62
PDB_00571 0.60 0.60 0.60 15 3296 10 6 4 0 10
PDB_00701 - 0.10 0.10 0.10 11 45342 98 9 89 0 98
PDB_00828 0.86 0.78 0.95 21 2463 1 0 1 0 6
PDB_00851 - 0.45 0.39 0.53 16 4723 14 0 14 0 25
PDB_00917 - 0.52 0.46 0.58 44 35169 39 4 28 7 51
PDB_01009 0.54 0.57 0.52 12 2462 12 5 6 1 9
RFA_00770 0.59 0.56 0.63 10 2000 9 0 6 3 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00808 0.65 0.56 0.75 9 2004 3 0 3 0 7
TMR_00036 0.56 0.54 0.59 55 90431 67 9 30 28 46
TMR_00123 0.46 0.48 0.45 48 66324 63 13 45 5 53
TMR_00180 0.63 0.64 0.62 63 67059 54 8 31 15 36
TMR_00240 0.57 0.61 0.54 52 63093 51 21 24 6 33
TMR_00352 0.35 0.40 0.31 30 95170 99 22 44 33 45
TMR_00353 0.42 0.47 0.39 49 84128 98 21 57 20 56
TMR_00357 0.38 0.37 0.38 34 82939 75 16 39 20 58
TMR_00361 - 0.30 0.38 0.23 27 93413 106 34 54 18 45
TMR_00374 0.25 0.26 0.24 24 81711 90 17 58 15 68
TMR_00384 0.29 0.29 0.30 31 65599 79 4 69 6 77
TMR_00395 0.52 0.50 0.56 54 64523 47 6 37 4 55
TMR_00398 0.44 0.43 0.44 46 65236 63 7 52 4 60
TMR_00399 0.35 0.34 0.36 32 64891 64 12 45 7 62
TMR_00430 0.23 0.23 0.22 25 82509 87 17 70 0 84
TMR_00431 0.67 0.69 0.64 38 51944 69 7 14 48 17
TMR_00443 0.50 0.48 0.53 50 67066 52 13 32 7 54
TMR_00457 0.43 0.44 0.43 45 78501 65 18 42 5 57
TMR_00469 0.51 0.53 0.50 53 64514 57 18 35 4 47
TMR_00502 0.22 0.24 0.20 22 75355 100 18 71 11 71
TMR_00503 0.42 0.41 0.43 46 67788 69 5 57 7 65
TMR_00519 0.40 0.38 0.42 36 63105 64 10 39 15 59
TMR_00528 0.30 0.29 0.31 28 63099 73 18 45 10 69
TMR_00541 0.40 0.41 0.38 43 61664 79 8 61 10 62
TMR_00547 0.39 0.40 0.38 40 65236 68 5 60 3 60
TMR_00562 0.35 0.34 0.36 35 72674 71 15 47 9 67
TMR_00566 0.64 0.61 0.67 61 60635 39 4 26 9 39
TMR_00571 0.62 0.61 0.64 60 60632 46 6 28 12 39
TMR_00584 0.58 0.57 0.59 55 60982 53 5 33 15 42
TMR_00594 0.16 0.17 0.15 18 79278 111 26 79 6 86
TMR_00605 0.54 0.52 0.55 56 74204 51 14 31 6 52
TMR_00609 0.69 0.68 0.70 77 63436 41 5 28 8 36
TMR_00624 0.68 0.69 0.67 75 62369 48 9 28 11 33
TMR_00683 0.16 0.18 0.14 18 82900 118 25 85 8 82
TMR_00698 0.48 0.45 0.51 47 63098 48 12 33 3 57
TMR_00703 0.48 0.47 0.48 47 67430 56 11 40 5 52
TMR_00706 0.57 0.52 0.61 54 66342 38 7 27 4 49
TMR_00711 0.61 0.62 0.60 61 67795 51 14 26 11 37

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 2258
Total TN 6805326
Total FP 13384
Total FP CONTRA 2402
Total FP INCONS 10499
Total FP COMP 483
Total FN 8674
Total Scores
MCC 0.174
Average MCC ± 95% Confidence Intervals 0.183 ± 0.028
Sensitivity 0.207
Positive Predictive Value 0.149
Nr of predictions 112

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.02 0.03 0.02 2 50914 131 38 86 7 62
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00122 0.27 0.30 0.24 26 43258 84 13 68 3 62
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00196 0.49 0.57 0.42 43 31524 62 16 43 3 32
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00227 0.28 0.31 0.25 41 78840 122 20 102 0 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00231 0.37 0.42 0.33 40 47773 84 17 65 2 56
ASE_00234 0.25 0.27 0.23 35 75315 117 10 106 1 94
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00248 0.13 0.15 0.12 17 62340 124 9 115 0 97
ASE_00250 0.25 0.29 0.23 38 78835 135 17 113 5 93
ASE_00254 0.15 0.16 0.14 13 36761 88 3 79 6 69
ASE_00255 0.11 0.12 0.10 16 74530 146 16 129 1 114
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00274 0.00 0.00 0.00 0 55487 126 12 112 2 103
ASE_00277 0.10 0.12 0.08 11 48071 123 23 100 0 80
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00287 0.15 0.17 0.14 17 54824 107 14 91 2 86
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00295 0.14 0.16 0.13 21 73761 140 19 119 2 110
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00318 0.03 0.04 0.03 5 80039 156 21 135 0 113
ASE_00335 0.10 0.12 0.09 14 75304 151 22 126 3 102
ASE_00339 0.25 0.29 0.22 34 80042 129 20 104 5 85
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00343 0.14 0.17 0.12 19 83275 145 31 111 3 94
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00370 0.03 0.04 0.03 3 41796 109 18 88 3 81
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00375 0.12 0.14 0.11 15 60246 120 10 107 3 95
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00377 0.25 0.27 0.23 29 57505 98 10 86 2 78
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00413 0.08 0.10 0.07 8 44438 108 19 86 3 73
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00417 0.32 0.36 0.28 36 54486 98 18 75 5 64
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00429 - 0.08 0.09 0.07 6 28114 84 14 69 1 60
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00434 0.29 0.34 0.25 37 68116 122 20 92 10 73
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
CRW_00648 - 0.05 0.06 0.04 9 137864 213 24 178 11 139
CRW_00654 - 0.41 0.47 0.36 58 78049 105 18 85 2 66
CRW_00658 - 0.21 0.26 0.16 27 74527 137 28 109 0 75
CRW_00663 - 0.08 0.10 0.07 6 26014 90 17 69 4 55
CRW_00664 - 0.14 0.19 0.11 15 53486 134 42 85 7 63
CRW_00671 0.18 0.21 0.16 24 62682 130 23 106 1 93
CRW_00672 0.36 0.43 0.31 48 72233 114 35 74 5 63
CRW_00674 0.16 0.19 0.14 23 83274 142 19 120 3 101
CRW_00676 0.11 0.14 0.09 16 93347 169 29 136 4 99
CRW_00685 - 0.11 0.15 0.08 16 156867 212 64 133 15 90
CRW_00688 - 0.33 0.40 0.27 23 21859 64 21 42 1 34
CRW_00721 - 0.22 0.31 0.15 21 58515 133 46 71 16 47
PDB_00078 - 0.00 0.00 0.00 0 49644 126 10 116 0 115
PDB_00278 - 0.04 0.06 0.04 4 24875 98 13 84 1 68
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00701 - 0.04 0.05 0.04 5 45319 127 14 113 0 104
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_00851 - 0.16 0.17 0.17 7 4711 35 3 32 0 34
PDB_00917 - 0.31 0.34 0.29 32 35136 81 10 67 4 63
PDB_01009 0.27 0.33 0.23 7 2455 25 3 20 2 14
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0
TMR_00036 0.22 0.29 0.17 29 90359 153 37 100 16 72
TMR_00123 0.19 0.23 0.16 23 66283 126 20 104 2 78
TMR_00180 0.12 0.16 0.10 16 66999 149 35 111 3 83
TMR_00240 0.23 0.31 0.17 26 63041 128 39 84 5 59
TMR_00352 0.07 0.09 0.05 7 95133 171 39 87 45 68
TMR_00353 0.41 0.51 0.32 54 84087 127 49 65 13 51
TMR_00357 0.26 0.34 0.19 31 82869 146 44 84 18 61
TMR_00361 - 0.06 0.10 0.04 7 93368 174 64 89 21 65
TMR_00374 0.09 0.13 0.07 12 81631 174 44 123 7 80
TMR_00384 0.17 0.20 0.14 22 65550 133 26 105 2 86
TMR_00395 0.27 0.31 0.24 34 64478 115 10 98 7 75
TMR_00398 0.05 0.07 0.05 7 65197 139 24 113 2 99
TMR_00399 0.20 0.26 0.16 24 64833 130 38 85 7 70
TMR_00430 0.18 0.23 0.15 25 82450 148 34 112 2 84
TMR_00431 0.24 0.33 0.17 18 51899 127 26 60 41 37
TMR_00443 0.17 0.20 0.15 21 67018 126 24 98 4 83
TMR_00457 0.19 0.25 0.15 25 78443 141 39 99 3 77
TMR_00469 0.10 0.12 0.08 12 64469 145 27 112 6 88
TMR_00502 0.14 0.19 0.11 18 75303 150 45 100 5 75
TMR_00503 0.11 0.14 0.10 15 67741 141 20 120 1 96
TMR_00519 0.04 0.05 0.03 5 63046 141 33 106 2 90
TMR_00528 0.13 0.15 0.11 15 63051 131 20 104 7 82
TMR_00541 0.12 0.14 0.10 15 61630 139 22 109 8 90
TMR_00547 0.28 0.35 0.23 35 65188 122 37 81 4 65
TMR_00562 0.09 0.12 0.08 12 72617 147 27 115 5 90
TMR_00566 0.13 0.16 0.11 16 60582 132 22 106 4 84
TMR_00571 0.05 0.06 0.04 6 60577 149 19 124 6 93
TMR_00584 0.01 0.01 0.01 1 60922 159 33 119 7 96
TMR_00594 0.08 0.10 0.06 10 79238 156 30 123 3 94
TMR_00605 0.28 0.35 0.23 38 74141 129 36 90 3 70
TMR_00609 0.53 0.62 0.45 70 63391 89 28 57 4 43
TMR_00624 0.36 0.44 0.30 47 62325 111 27 82 2 61
TMR_00683 0.01 0.02 0.01 2 82854 176 50 122 4 98
TMR_00698 0.20 0.24 0.17 25 63042 124 27 96 1 79
TMR_00703 0.10 0.12 0.08 12 67376 140 26 114 0 87
TMR_00706 0.14 0.17 0.11 17 66281 133 29 103 1 86
TMR_00711 0.18 0.22 0.14 22 67740 137 41 93 3 76

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.