CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASLOpt		CMfinder(seed)
MCC	0.474	>	0.373
Average MCC ± 95% Confidence Intervals	0.514 ± 0.098	>	0.410 ± 0.092
Sensitivity	0.443	>	0.200
Positive Predictive Value	0.510	<	0.698
Total TP	579	>	261
Total TN	666976	<	667737
Total FP	612	>	114
Total FP CONTRA	82	>	5
Total FP INCONS	474	>	108
Total FP COMP	56	>	1
Total FN	729	<	1047
P-value	5.02343278931e-08

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Performance plots

Comparison of performance of RNASLOpt and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	579
Total TN	666976
Total FP	612
Total FP CONTRA	82
Total FP INCONS	474
Total FP COMP	56
Total FN	729

Total Scores
MCC	0.474
Average MCC ± 95% Confidence Intervals	0.514 ± 0.098
Sensitivity	0.443
Positive Predictive Value	0.510
Nr of predictions	22

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.48	0.45	0.52	54	77317	58	5	45	8	66
CRW_00610	Intron_gpI links to Rfam database...	0.06	0.06	0.07	5	36246	64	9	55	0	76
CRW_00613	Intron_gpI links to Rfam database...	0.59	0.50	0.70	39	34924	24	1	16	7	39
CRW_00618	Intron_gpI links to Rfam database...	0.21	0.21	0.21	13	56218	62	6	43	13	48
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.49	0.51	52	63444	52	5	45	2	54
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.50	0.51	47	64527	48	11	35	2	47
CRW_00670	Intron_gpI links to Rfam database...	0.45	0.43	0.47	52	70015	58	8	50	0	68
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.53	0.68	62	62744	32	2	27	3	55
CRW_00672	Intron_gpI links to Rfam database...	0.43	0.41	0.45	45	72291	57	6	48	3	66
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.33	31	68540	77	20	44	13	59
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2680	22	0	21	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.74	0.60	0.91	49	26974	7	0	5	2	32
PDB_01092	glmS links to Rfam database...	0.74	0.63	0.87	33	10115	7	1	4	2	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.59	0.57	0.62	16	4069	10	2	8	0	12
RFA_00636	HDV_ribozyme links to Rfam database...	0.65	0.64	0.67	18	3978	9	2	7	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.47	0.39	0.58	7	2004	5	1	4	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	261
Total TN	667737
Total FP	114
Total FP CONTRA	5
Total FP INCONS	108
Total FP COMP	1
Total FN	1047

Total Scores
MCC	0.373
Average MCC ± 95% Confidence Intervals	0.410 ± 0.092
Sensitivity	0.200
Positive Predictive Value	0.698
Nr of predictions	22

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]