CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASLOpt		Carnac(seed)
MCC	0.461	>	0.178
Average MCC ± 95% Confidence Intervals	0.484 ± 0.057	>	0.135 ± 0.088
Sensitivity	0.425	>	0.033
Positive Predictive Value	0.503	<	0.962
Total TP	1296	>	101
Total TN	1536316	<	1538786
Total FP	1368	>	5
Total FP CONTRA	153	>	3
Total FP INCONS	1126	>	1
Total FP COMP	89	>	1
Total FN	1755	<	2950
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASLOpt and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and Carnac(seed)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	1296
Total TN	1536316
Total FP	1368
Total FP CONTRA	153
Total FP INCONS	1126
Total FP COMP	89
Total FN	1755

Total Scores
MCC	0.461
Average MCC ± 95% Confidence Intervals	0.484 ± 0.057
Sensitivity	0.425
Positive Predictive Value	0.503
Nr of predictions	44

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.55	0.49	0.61	37	34130	30	3	21	6	38
ASE_00002	RNaseP_arch links to Rfam database...	0.64	0.58	0.71	42	35452	20	2	15	3	31
ASE_00009	RNaseP_arch links to Rfam database...	0.44	0.40	0.47	27	26049	30	3	27	0	40
ASE_00014	RNaseP_arch links to Rfam database...	0.59	0.54	0.64	57	54196	33	3	29	1	49
ASE_00116	RNaseP_arch links to Rfam database...	0.24	0.21	0.29	14	31577	35	3	32	0	52
ASE_00120	RNaseP_arch links to Rfam database...	0.68	0.63	0.75	59	46892	20	4	16	0	35
ASE_00121	RNaseP_arch links to Rfam database...	0.46	0.42	0.50	39	45072	39	6	33	0	53
ASE_00145	RNaseP_arch links to Rfam database...	0.45	0.40	0.51	44	70039	45	1	41	3	67
ASE_00154	RNaseP_arch links to Rfam database...	0.41	0.36	0.45	39	65255	48	3	44	1	68
ASE_00187	RNaseP_arch links to Rfam database...	0.46	0.43	0.50	49	68537	52	7	42	3	66
ASE_00196	RNaseP_arch links to Rfam database...	0.41	0.37	0.46	28	31565	36	2	31	3	47
ASE_00205	RNaseP_arch links to Rfam database...	0.43	0.41	0.46	37	45975	47	6	38	3	53
ASE_00209	RNaseP_arch links to Rfam database...	0.50	0.42	0.59	37	43008	26	2	24	0	51
ASE_00210	RNaseP_arch links to Rfam database...	0.36	0.34	0.38	22	27203	38	4	32	2	43
ASE_00213	RNaseP_arch links to Rfam database...	0.21	0.18	0.24	12	27210	41	2	37	2	54
ASE_00346	RNaseP_arch links to Rfam database...	0.53	0.47	0.61	46	48129	32	3	27	2	51
ASE_00359	RNaseP_arch links to Rfam database...	0.51	0.46	0.57	37	42713	28	2	26	0	43
ASE_00360	RNaseP_arch links to Rfam database...	0.43	0.38	0.49	25	29352	26	7	19	0	40
ASE_00417	RNaseP_arch links to Rfam database...	0.43	0.41	0.45	41	54523	53	4	47	2	59
ASE_00418	RNaseP_arch links to Rfam database...	0.07	0.07	0.07	5	38710	68	4	62	2	70
CRW_00016	Intron_gpI links to Rfam database...	0.48	0.45	0.52	54	77317	58	5	45	8	66
CRW_00610	Intron_gpI links to Rfam database...	0.06	0.06	0.07	5	36246	64	9	55	0	76
CRW_00613	Intron_gpI links to Rfam database...	0.59	0.50	0.70	39	34924	24	1	16	7	39
CRW_00618	Intron_gpI links to Rfam database...	0.21	0.21	0.21	13	56218	62	6	43	13	48
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.49	0.51	52	63444	52	5	45	2	54
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.50	0.51	47	64527	48	11	35	2	47
CRW_00670	Intron_gpI links to Rfam database...	0.45	0.43	0.47	52	70015	58	8	50	0	68
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.53	0.68	62	62744	32	2	27	3	55
CRW_00672	Intron_gpI links to Rfam database...	0.43	0.41	0.45	45	72291	57	6	48	3	66
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.33	31	68540	77	20	44	13	59
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2680	22	0	21	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.74	0.60	0.91	49	26974	7	0	5	2	32
PDB_01092	glmS links to Rfam database...	0.74	0.63	0.87	33	10115	7	1	4	2	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.59	0.57	0.62	16	4069	10	2	8	0	12
RFA_00636	HDV_ribozyme links to Rfam database...	0.65	0.64	0.67	18	3978	9	2	7	0	10
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1876	5	0	5	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.47	0.39	0.58	7	2004	5	1	4	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	101
Total TN	1538786
Total FP	5
Total FP CONTRA	3
Total FP INCONS	1
Total FP COMP	1
Total FN	2950

Total Scores
MCC	0.178
Average MCC ± 95% Confidence Intervals	0.135 ± 0.088
Sensitivity	0.033
Positive Predictive Value	0.962
Nr of predictions	44

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]