CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		MaxExpect
MCC	0.553	>	0.469
Average MCC ± 95% Confidence Intervals	0.570 ± 0.039	>	0.490 ± 0.052
Sensitivity	0.434	<	0.455
Positive Predictive Value	0.705	>	0.484
Total TP	1981	<	2077
Total TN	2918978	>	2917498
Total FP	1029	<	2566
Total FP CONTRA	247	<	419
Total FP INCONS	580	<	1792
Total FP COMP	202	<	355
Total FN	2585	>	2489
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and MaxExpect).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and MaxExpect).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and MaxExpect).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1981
Total TN	2918978
Total FP	1029
Total FP CONTRA	247
Total FP INCONS	580
Total FP COMP	202
Total FN	2585

Total Scores
MCC	0.553
Average MCC ± 95% Confidence Intervals	0.570 ± 0.039
Sensitivity	0.434
Positive Predictive Value	0.705
Nr of predictions	50

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.77	0.59	1.00	20	4351	1	0	0	1	14
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP	2077
Total TN	2917498
Total FP	2566
Total FP CONTRA	419
Total FP INCONS	1792
Total FP COMP	355
Total FN	2489

Total Scores
MCC	0.469
Average MCC ± 95% Confidence Intervals	0.490 ± 0.052
Sensitivity	0.455
Positive Predictive Value	0.484
Nr of predictions	50

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.39	0.39	0.38	35	45359	64	6	51	7	54
ASE_00090	RNaseP_bact_a links to Rfam database...	0.67	0.67	0.67	68	55509	41	4	30	7	33
ASE_00135	RNaseP_bact_a links to Rfam database...	0.66	0.63	0.68	69	63089	39	1	31	7	40
ASE_00153	RNaseP_nuc links to Rfam database...	0.57	0.59	0.54	43	57551	71	8	28	35	30
ASE_00215	RNaseP_bact_a links to Rfam database...	0.60	0.58	0.63	57	48425	38	5	29	4	42
ASE_00328	RNaseP_bact_b links to Rfam database...	0.67	0.63	0.73	70	72675	40	4	22	14	42
ASE_00361	RNaseP_bact_a links to Rfam database...	0.54	0.53	0.56	67	75347	55	10	42	3	60
ASE_00441	RNaseP_bact_a links to Rfam database...	0.79	0.74	0.84	83	64162	21	1	15	5	29
PDB_00571	tRNA links to Rfam database...	0.42	0.36	0.50	9	3303	9	2	7	0	16
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.86	0.74	1.00	25	4346	1	0	0	1	9
TMR_00017	tmRNA links to Rfam database...	0.51	0.49	0.53	50	67067	50	10	34	6	52
TMR_00018	tmRNA links to Rfam database...	0.37	0.37	0.37	34	64527	63	11	48	4	58
TMR_00042	tmRNA links to Rfam database...	0.35	0.35	0.36	34	62740	64	3	58	3	64
TMR_00046	tmRNA links to Rfam database...	0.28	0.28	0.28	27	62740	72	11	57	4	69
TMR_00048	tmRNA links to Rfam database...	0.23	0.24	0.23	23	64880	83	15	62	6	72
TMR_00080	tmRNA links to Rfam database...	0.41	0.40	0.42	38	70409	53	14	39	0	58
TMR_00082	tmRNA links to Rfam database...	0.70	0.68	0.71	65	67805	31	8	18	5	31
TMR_00123	tmRNA links to Rfam database...	0.40	0.39	0.41	39	66335	61	11	45	5	62
TMR_00137	tmRNA links to Rfam database...	0.22	0.21	0.22	19	60990	74	9	57	8	70
TMR_00142	tmRNA links to Rfam database...	0.50	0.51	0.50	52	70771	65	10	43	12	50
TMR_00207	tmRNA links to Rfam database...	0.29	0.28	0.30	29	72294	71	7	60	4	74
TMR_00257	tmRNA links to Rfam database...	0.12	0.11	0.12	11	67072	82	7	71	4	87
TMR_00271	tmRNA links to Rfam database...	0.64	0.60	0.67	55	64179	37	6	21	10	36
TMR_00332	tmRNA links to Rfam database...	0.49	0.43	0.54	43	67082	41	7	29	5	56
TMR_00366	tmRNA links to Rfam database...	0.51	0.51	0.52	51	67798	58	12	35	11	49
TMR_00378	tmRNA links to Rfam database...	0.26	0.25	0.28	24	67810	73	14	48	11	73
TMR_00404	tmRNA links to Rfam database...	0.37	0.40	0.35	37	67422	80	26	43	11	55
TMR_00427	tmRNA links to Rfam database...	0.34	0.32	0.36	31	67441	61	13	43	5	66
TMR_00443	tmRNA links to Rfam database...	0.54	0.51	0.57	53	67068	47	11	29	7	51
TMR_00451	tmRNA links to Rfam database...	0.18	0.19	0.18	17	63449	84	20	60	4	72
TMR_00458	tmRNA links to Rfam database...	0.46	0.46	0.46	43	63453	57	9	41	7	50
TMR_00469	tmRNA links to Rfam database...	0.53	0.53	0.52	53	64519	52	17	31	4	47
TMR_00472	tmRNA links to Rfam database...	0.42	0.40	0.44	39	64532	60	8	41	11	58
TMR_00519	tmRNA links to Rfam database...	0.39	0.39	0.40	37	63098	66	12	43	11	58
TMR_00520	tmRNA links to Rfam database...	0.52	0.52	0.53	51	63094	55	14	31	10	48
TMR_00522	tmRNA links to Rfam database...	0.39	0.39	0.40	38	63095	66	13	44	9	59
TMR_00528	tmRNA links to Rfam database...	0.30	0.29	0.32	28	63102	70	16	44	10	69
TMR_00540	tmRNA links to Rfam database...	0.44	0.41	0.47	43	73444	60	11	38	11	61
TMR_00568	tmRNA links to Rfam database...	0.36	0.34	0.38	34	60636	62	4	52	6	65
TMR_00571	tmRNA links to Rfam database...	0.66	0.61	0.71	60	60642	38	2	22	14	39
TMR_00580	tmRNA links to Rfam database...	0.68	0.64	0.72	64	60637	36	2	23	11	36
TMR_00584	tmRNA links to Rfam database...	0.59	0.57	0.61	55	60985	47	3	32	12	42
TMR_00586	tmRNA links to Rfam database...	0.50	0.49	0.51	48	60980	57	8	39	10	49
TMR_00616	tmRNA links to Rfam database...	0.41	0.40	0.41	40	67064	62	12	45	5	59
TMR_00699	tmRNA links to Rfam database...	0.49	0.44	0.55	45	67079	42	4	33	5	57
TMR_00702	tmRNA links to Rfam database...	0.39	0.36	0.42	36	67075	55	12	38	5	64
TMR_00703	tmRNA links to Rfam database...	0.50	0.49	0.52	49	67433	51	6	40	5	50

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

2. Individual counts for MaxExpect [ download as .csv ]