CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		RNAwolf
MCC	0.553	>	0.296
Average MCC ± 95% Confidence Intervals	0.570 ± 0.039	>	0.328 ± 0.052
Sensitivity	0.434	>	0.315
Positive Predictive Value	0.705	>	0.281
Total TP	1981	>	1438
Total TN	2918978	>	2916673
Total FP	1029	<	4121
Total FP CONTRA	247	<	765
Total FP INCONS	580	<	2910
Total FP COMP	202	<	446
Total FN	2585	<	3128
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RNAwolf).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1981
Total TN	2918978
Total FP	1029
Total FP CONTRA	247
Total FP INCONS	580
Total FP COMP	202
Total FN	2585

Total Scores
MCC	0.553
Average MCC ± 95% Confidence Intervals	0.570 ± 0.039
Sensitivity	0.434
Positive Predictive Value	0.705
Nr of predictions	50

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.77	0.59	1.00	20	4351	1	0	0	1	14
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP	1438
Total TN	2916673
Total FP	4121
Total FP CONTRA	765
Total FP INCONS	2910
Total FP COMP	446
Total FN	3128

Total Scores
MCC	0.296
Average MCC ± 95% Confidence Intervals	0.328 ± 0.052
Sensitivity	0.315
Positive Predictive Value	0.281
Nr of predictions	50

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.19	0.19	0.19	17	45361	82	13	60	9	72
ASE_00090	RNaseP_bact_a links to Rfam database...	0.32	0.33	0.31	33	55504	91	4	70	17	68
ASE_00135	RNaseP_bact_a links to Rfam database...	0.45	0.46	0.45	50	63078	74	12	50	12	59
ASE_00153	RNaseP_nuc links to Rfam database...	0.33	0.38	0.29	28	57534	96	15	53	28	45
ASE_00215	RNaseP_bact_a links to Rfam database...	0.28	0.28	0.29	28	48418	83	6	64	13	71
ASE_00328	RNaseP_bact_b links to Rfam database...	0.51	0.49	0.53	55	72667	61	5	44	12	57
ASE_00361	RNaseP_bact_a links to Rfam database...	0.36	0.37	0.35	47	75333	94	11	75	8	80
ASE_00441	RNaseP_bact_a links to Rfam database...	0.45	0.46	0.45	51	64147	73	3	60	10	61
PDB_00571	tRNA links to Rfam database...	0.89	0.84	0.95	21	3299	2	1	0	1	4
PDB_00828	Purine links to Rfam database...	0.85	0.81	0.88	22	2460	3	1	2	0	5
PDB_00829	Purine links to Rfam database...	0.78	0.75	0.82	18	2256	4	1	3	0	6
PDB_01020	Purine links to Rfam database...	0.84	0.83	0.86	19	2256	5	1	2	2	4
PDB_01073	SAM links to Rfam database...	0.17	0.18	0.17	6	4336	29	3	26	0	28
TMR_00017	tmRNA links to Rfam database...	0.27	0.26	0.27	27	67061	85	12	61	12	75
TMR_00018	tmRNA links to Rfam database...	0.34	0.37	0.32	34	64515	80	23	48	9	58
TMR_00042	tmRNA links to Rfam database...	0.24	0.24	0.24	24	62737	83	11	63	9	74
TMR_00046	tmRNA links to Rfam database...	0.38	0.42	0.35	40	62722	90	15	58	17	56
TMR_00048	tmRNA links to Rfam database...	0.51	0.55	0.47	52	64870	70	16	42	12	43
TMR_00080	tmRNA links to Rfam database...	0.19	0.22	0.17	21	70379	108	32	68	8	75
TMR_00082	tmRNA links to Rfam database...	0.30	0.33	0.28	32	67782	91	23	59	9	64
TMR_00123	tmRNA links to Rfam database...	0.21	0.23	0.21	23	66318	95	16	73	6	78
TMR_00137	tmRNA links to Rfam database...	0.30	0.34	0.27	30	60965	85	25	55	5	59
TMR_00142	tmRNA links to Rfam database...	0.30	0.33	0.28	34	70753	96	25	64	7	68
TMR_00207	tmRNA links to Rfam database...	0.26	0.27	0.25	28	72276	92	17	69	6	75
TMR_00257	tmRNA links to Rfam database...	0.26	0.29	0.24	28	67045	100	17	71	12	70
TMR_00271	tmRNA links to Rfam database...	0.19	0.21	0.18	19	64156	98	18	68	12	72
TMR_00332	tmRNA links to Rfam database...	0.27	0.29	0.25	29	67043	96	21	68	7	70
TMR_00366	tmRNA links to Rfam database...	0.25	0.27	0.23	27	67778	97	19	72	6	73
TMR_00378	tmRNA links to Rfam database...	0.17	0.20	0.15	19	67773	107	29	75	3	78
TMR_00404	tmRNA links to Rfam database...	0.20	0.22	0.18	20	67416	98	13	79	6	72
TMR_00427	tmRNA links to Rfam database...	0.15	0.15	0.14	15	67420	98	21	72	5	82
TMR_00443	tmRNA links to Rfam database...	0.23	0.25	0.22	26	67043	107	10	82	15	78
TMR_00451	tmRNA links to Rfam database...	0.15	0.17	0.13	15	63432	103	35	64	4	74
TMR_00458	tmRNA links to Rfam database...	0.32	0.33	0.30	31	63443	80	16	56	8	62
TMR_00469	tmRNA links to Rfam database...	0.17	0.19	0.16	19	64500	111	14	87	10	81
TMR_00472	tmRNA links to Rfam database...	0.26	0.27	0.25	26	64516	87	16	62	9	71
TMR_00519	tmRNA links to Rfam database...	0.14	0.15	0.13	14	63085	101	22	69	10	81
TMR_00520	tmRNA links to Rfam database...	0.17	0.18	0.16	18	63075	102	28	69	5	81
TMR_00522	tmRNA links to Rfam database...	0.27	0.30	0.24	29	63068	94	31	62	1	68
TMR_00528	tmRNA links to Rfam database...	0.23	0.25	0.22	24	63081	92	28	57	7	73
TMR_00540	tmRNA links to Rfam database...	0.26	0.28	0.24	29	73417	98	15	75	8	75
TMR_00568	tmRNA links to Rfam database...	0.39	0.39	0.39	39	60625	76	15	47	14	60
TMR_00571	tmRNA links to Rfam database...	0.50	0.51	0.50	50	60625	71	7	44	20	49
TMR_00580	tmRNA links to Rfam database...	0.43	0.45	0.41	45	60615	82	7	59	16	55
TMR_00584	tmRNA links to Rfam database...	0.27	0.28	0.26	27	60972	91	13	63	15	70
TMR_00586	tmRNA links to Rfam database...	0.47	0.49	0.44	48	60967	74	19	41	14	49
TMR_00616	tmRNA links to Rfam database...	0.36	0.39	0.34	39	67045	86	14	63	9	60
TMR_00699	tmRNA links to Rfam database...	0.23	0.25	0.22	25	67048	94	15	73	6	77
TMR_00702	tmRNA links to Rfam database...	0.13	0.14	0.12	14	67047	107	9	91	7	86
TMR_00703	tmRNA links to Rfam database...	0.21	0.23	0.20	23	67411	99	22	72	5	76

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

2. Individual counts for RNAwolf [ download as .csv ]