CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(20)		RSpredict(seed)
MCC	0.526	>	0.166
Average MCC ± 95% Confidence Intervals	0.595 ± 0.129	>	0.205 ± 0.197
Sensitivity	0.384	>	0.052
Positive Predictive Value	0.723	>	0.539
Total TP	357	>	48
Total TN	493814	<	494219
Total FP	165	>	45
Total FP CONTRA	16	>	7
Total FP INCONS	121	>	34
Total FP COMP	28	>	4
Total FN	573	<	882
P-value	1.55268413083e-08

Comparison of performance of RNASampler(20) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

Total Scores
MCC	0.526
Average MCC ± 95% Confidence Intervals	0.595 ± 0.129
Sensitivity	0.384
Positive Predictive Value	0.723
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.77	0.59	1.00	20	4351	1	0	0	1	14

Total Scores
MCC	0.166
Average MCC ± 95% Confidence Intervals	0.205 ± 0.197
Sensitivity	0.052
Positive Predictive Value	0.539
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45448	3	0	3	0	89
ASE_00090	RNaseP_bact_a links to Rfam database...	0.04	0.01	0.17	1	55605	5	0	5	0	100
ASE_00135	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	63187	3	0	3	0	109
ASE_00153	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	57629	1	1	0	0	73
ASE_00215	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	48513	3	0	3	0	99
ASE_00328	RNaseP_bact_b links to Rfam database...	0.00	0.00	0.00	0	72760	15	0	11	4	112
ASE_00361	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	75463	3	0	3	0	127
ASE_00441	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	64258	3	0	3	0	112
PDB_00828	Purine links to Rfam database...	0.54	0.41	0.73	11	2470	4	2	2	0	16
PDB_00829	Purine links to Rfam database...	0.74	0.63	0.88	15	2261	2	2	0	0	9
PDB_01020	Purine links to Rfam database...	0.76	0.65	0.88	15	2261	2	2	0	0	8
PDB_01073	SAM links to Rfam database...	0.39	0.18	0.86	6	4364	1	0	1	0	28

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.