CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		Carnac(seed)
MCC	0.644	>	0.253
Average MCC ± 95% Confidence Intervals	0.610 ± 0.041	>	0.107 ± 0.067
Sensitivity	0.465	>	0.068
Positive Predictive Value	0.894	<	0.940
Total TP	2471	>	362
Total TN	4546432	<	4548811
Total FP	384	>	40
Total FP CONTRA	29	>	9
Total FP INCONS	264	>	14
Total FP COMP	91	>	17
Total FN	2843	<	4952
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Carnac(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	2471
Total TN	4546432
Total FP	384
Total FP CONTRA	29
Total FP INCONS	264
Total FP COMP	91
Total FN	2843

Total Scores
MCC	0.644
Average MCC ± 95% Confidence Intervals	0.610 ± 0.041
Sensitivity	0.465
Positive Predictive Value	0.894
Nr of predictions	62

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.77	0.59	1.00	44	34147	0	0	0	0	31
ASE_00002	RNaseP_arch links to Rfam database...	0.78	0.60	1.00	44	35467	0	0	0	0	29
ASE_00009	RNaseP_arch links to Rfam database...	0.74	0.60	0.93	40	26063	3	0	3	0	27
ASE_00014	RNaseP_arch links to Rfam database...	0.70	0.52	0.95	55	54227	3	0	3	0	51
ASE_00116	RNaseP_arch links to Rfam database...	0.82	0.68	0.98	45	31580	1	0	1	0	21
ASE_00120	RNaseP_arch links to Rfam database...	0.76	0.59	0.98	55	46915	2	0	1	1	39
ASE_00121	RNaseP_arch links to Rfam database...	0.77	0.61	0.98	56	45093	1	0	1	0	36
ASE_00145	RNaseP_arch links to Rfam database...	0.73	0.54	1.00	60	70065	0	0	0	0	51
ASE_00148	RNaseP_arch links to Rfam database...	0.59	0.37	0.95	57	112515	3	0	3	0	97
ASE_00154	RNaseP_arch links to Rfam database...	0.71	0.53	0.95	57	65281	3	0	3	0	50
ASE_00155	RNaseP_arch links to Rfam database...	0.65	0.42	1.00	60	93468	0	0	0	0	82
ASE_00187	RNaseP_arch links to Rfam database...	0.65	0.46	0.91	53	68577	5	1	4	0	62
ASE_00196	RNaseP_arch links to Rfam database...	0.77	0.63	0.96	47	31577	2	0	2	0	28
ASE_00205	RNaseP_arch links to Rfam database...	0.77	0.60	1.00	54	46002	1	0	0	1	36
ASE_00209	RNaseP_arch links to Rfam database...	0.79	0.64	0.98	56	43014	1	0	1	0	32
ASE_00210	RNaseP_arch links to Rfam database...	0.68	0.55	0.84	36	27218	9	0	7	2	29
ASE_00213	RNaseP_arch links to Rfam database...	0.78	0.62	0.98	41	27219	3	0	1	2	25
ASE_00222	RNaseP_arch links to Rfam database...	0.62	0.38	1.00	60	112041	0	0	0	0	97
ASE_00346	RNaseP_arch links to Rfam database...	0.57	0.44	0.74	43	48147	15	0	15	0	54
ASE_00359	RNaseP_arch links to Rfam database...	0.73	0.55	0.98	44	42733	2	0	1	1	36
ASE_00360	RNaseP_arch links to Rfam database...	0.82	0.69	0.98	45	29357	1	0	1	0	20
ASE_00417	RNaseP_arch links to Rfam database...	0.76	0.59	0.98	59	54555	1	0	1	0	41
ASE_00418	RNaseP_arch links to Rfam database...	0.77	0.60	0.98	45	38735	1	0	1	0	30
CRW_00013	Intron_gpI links to Rfam database...	0.46	0.23	0.90	27	103710	3	0	3	0	88
CRW_00016	Intron_gpI links to Rfam database...	0.45	0.23	0.90	27	77391	3	0	3	0	93
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00610	Intron_gpI links to Rfam database...	0.54	0.31	0.96	25	36289	3	0	1	2	56
CRW_00613	Intron_gpI links to Rfam database...	0.42	0.22	0.81	17	34959	6	0	4	2	61
CRW_00614	Intron_gpI links to Rfam database...	0.45	0.32	0.64	18	121743	11	2	8	1	39
CRW_00618	Intron_gpI links to Rfam database...	0.39	0.26	0.59	16	56253	11	2	9	0	45
CRW_00619	Intron_gpI links to Rfam database...	0.41	0.23	0.74	17	165002	7	0	6	1	56
CRW_00620	Intron_gpI links to Rfam database...	0.35	0.21	0.59	13	150953	16	0	9	7	50
CRW_00621	Intron_gpI links to Rfam database...	0.36	0.21	0.60	15	153156	11	2	8	1	56
CRW_00623	Intron_gpI links to Rfam database...	0.35	0.18	0.68	15	129773	9	1	6	2	68
CRW_00633	Intron_gpI links to Rfam database...	0.40	0.21	0.76	22	63517	7	2	5	0	84
CRW_00634	Intron_gpI links to Rfam database...	0.37	0.18	0.74	17	64597	12	0	6	6	77
CRW_00670	Intron_gpI links to Rfam database...	0.48	0.24	0.97	29	70095	1	0	1	0	91
CRW_00671	Intron_gpI links to Rfam database...	0.49	0.25	0.97	29	62805	1	0	1	0	88
CRW_00672	Intron_gpI links to Rfam database...	0.50	0.26	0.97	29	72360	1	0	1	0	82
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.14	0.63	17	83409	10	6	4	0	107
CRW_00676	Intron_gpI links to Rfam database...	0.32	0.15	0.68	17	93503	13	0	8	5	98
CRW_00692	Intron_gpI links to Rfam database...	0.34	0.17	0.68	15	68613	13	0	7	6	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.59	0.36	1.00	5	941	0	0	0	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	0.60	0.43	0.83	10	2689	2	0	2	0	13
PDB_00827	Intron_gpI links to Rfam database...	0.35	0.21	0.59	17	26999	12	2	10	0	64
PDB_01092	glmS links to Rfam database...	0.70	0.54	0.90	28	10122	4	0	3	1	24
RFA_00597	Telomerase-vert links to Rfam database...	0.71	0.61	0.84	66	97824	18	0	13	5	43
RFA_00598	Telomerase-vert links to Rfam database...	0.68	0.58	0.79	59	84591	25	0	16	9	42
RFA_00599	Telomerase-vert links to Rfam database...	0.79	0.66	0.95	73	101398	7	0	4	3	38
RFA_00600	Telomerase-vert links to Rfam database...	0.76	0.63	0.91	63	120226	15	0	6	9	37
RFA_00601	Telomerase-vert links to Rfam database...	0.79	0.67	0.93	76	99153	10	0	6	4	38
RFA_00602	Telomerase-vert links to Rfam database...	0.76	0.65	0.90	75	101392	11	0	8	3	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.49	0.32	0.75	9	4083	3	2	1	0	19
RFA_00636	HDV_ribozyme links to Rfam database...	0.49	0.32	0.75	9	3993	3	2	1	0	19
RFA_00767	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1878	3	0	3	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1878	3	0	3	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	2003	3	0	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	362
Total TN	4548811
Total FP	40
Total FP CONTRA	9
Total FP INCONS	14
Total FP COMP	17
Total FN	4952

Total Scores
MCC	0.253
Average MCC ± 95% Confidence Intervals	0.107 ± 0.067
Sensitivity	0.068
Positive Predictive Value	0.940
Nr of predictions	62

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]