CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAfold		CMfinder(seed)
MCC	0.466	>	0.363
Average MCC ± 95% Confidence Intervals	0.452 ± 0.090	>	0.399 ± 0.081
Sensitivity	0.466	>	0.184
Positive Predictive Value	0.468	<	0.716
Total TP	801	>	317
Total TN	1068873	<	1070143
Total FP	1090	>	134
Total FP CONTRA	192	>	6
Total FP INCONS	720	>	120
Total FP COMP	178	>	8
Total FN	918	<	1402
P-value	5.19332990918e-08

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Performance plots

Comparison of performance of RNAfold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAfold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and CMfinder(seed)).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP	801
Total TN	1068873
Total FP	1090
Total FP CONTRA	192
Total FP INCONS	720
Total FP COMP	178
Total FN	918

Total Scores
MCC	0.466
Average MCC ± 95% Confidence Intervals	0.452 ± 0.090
Sensitivity	0.466
Positive Predictive Value	0.468
Nr of predictions	26

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.21	0.22	0.21	25	103623	116	12	80	24	90
CRW_00016	Intron_gpI links to Rfam database...	0.64	0.62	0.67	74	77311	47	5	31	11	46
CRW_00610	Intron_gpI links to Rfam database...	0.21	0.21	0.22	17	36239	59	7	52	0	64
CRW_00613	Intron_gpI links to Rfam database...	0.65	0.60	0.70	47	34913	28	1	19	8	31
CRW_00614	Intron_gpI links to Rfam database...	0.16	0.19	0.14	11	121692	131	25	43	63	46
CRW_00618	Intron_gpI links to Rfam database...	0.12	0.13	0.12	8	56212	82	13	47	22	53
CRW_00633	Intron_gpI links to Rfam database...	0.44	0.43	0.45	46	63444	58	13	43	2	60
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.52	0.49	49	64519	57	10	42	5	45
CRW_00670	Intron_gpI links to Rfam database...	0.69	0.68	0.71	82	70009	36	9	25	2	38
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.59	0.61	69	62722	49	6	38	5	48
CRW_00672	Intron_gpI links to Rfam database...	0.48	0.50	0.47	55	72273	65	19	43	3	56
CRW_00674	Intron_gpI links to Rfam database...	0.53	0.53	0.52	66	83310	62	12	48	2	58
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	74	17	41	16	51
CRW_00692	Intron_gpI links to Rfam database...	0.40	0.42	0.38	38	68536	66	24	37	5	52
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2678	24	1	22	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.46	0.55	37	26961	31	1	29	1	44
PDB_01092	glmS links to Rfam database...	0.71	0.63	0.80	33	10112	10	1	7	2	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.38	0.39	0.37	11	4065	19	2	17	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00769	Corona_pk3 links to Rfam database...	0.52	0.56	0.50	10	1933	10	4	6	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	5	0	2	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	2	6	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	18	2	13	3	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	11	1	10	0	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	317
Total TN	1070143
Total FP	134
Total FP CONTRA	6
Total FP INCONS	120
Total FP COMP	8
Total FN	1402

Total Scores
MCC	0.363
Average MCC ± 95% Confidence Intervals	0.399 ± 0.081
Sensitivity	0.184
Positive Predictive Value	0.716
Nr of predictions	26

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

2. Individual counts for RNAfold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]