CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAfold - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAfold & NanoFolder [.zip] - may take several seconds...


Overview

Metric RNAfold NanoFolder
MCC 0.493 > 0.174
Average MCC ± 95% Confidence Intervals 0.488 ± 0.034 > 0.183 ± 0.028
Sensitivity 0.491 > 0.207
Positive Predictive Value 0.497 > 0.149
Total TP 5369 > 2258
Total TN 6809678 > 6805326
Total FP 6111 < 13384
Total FP CONTRA 944 < 2402
Total FP INCONS 4494 < 10499
Total FP COMP 673 > 483
Total FN 5563 < 8674
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAfold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAfold and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and NanoFolder).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 5369
Total TN 6809678
Total FP 6111
Total FP CONTRA 944
Total FP INCONS 4494
Total FP COMP 673
Total FN 5563
Total Scores
MCC 0.493
Average MCC ± 95% Confidence Intervals 0.488 ± 0.034
Sensitivity 0.491
Positive Predictive Value 0.497
Nr of predictions 112

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.26 0.28 0.24 18 50966 73 6 50 17 46
ASE_00083 0.79 0.75 0.83 83 62381 23 2 15 6 27
ASE_00122 0.28 0.27 0.29 24 43283 59 4 54 1 64
ASE_00185 0.80 0.76 0.84 97 73421 25 3 15 7 31
ASE_00190 0.50 0.48 0.52 43 45368 44 2 38 4 47
ASE_00196 0.75 0.73 0.76 55 31554 21 2 15 4 20
ASE_00221 0.58 0.53 0.64 62 64523 38 3 32 3 55
ASE_00227 0.30 0.29 0.32 38 78884 81 6 75 0 95
ASE_00228 0.60 0.60 0.59 52 46883 36 14 22 0 34
ASE_00229 0.60 0.60 0.61 52 42401 33 10 23 0 35
ASE_00231 0.69 0.69 0.70 66 47801 28 5 23 0 30
ASE_00234 0.58 0.53 0.63 68 75358 45 5 35 5 61
ASE_00238 0.62 0.61 0.63 70 64150 46 2 39 5 44
ASE_00248 0.47 0.43 0.51 49 62384 48 3 45 0 65
ASE_00250 0.61 0.59 0.64 77 78882 47 4 40 3 54
ASE_00254 0.74 0.72 0.77 59 36779 24 5 13 6 23
ASE_00255 0.47 0.45 0.50 59 74572 60 7 53 0 71
ASE_00257 0.64 0.64 0.64 62 50943 35 1 34 0 35
ASE_00267 0.32 0.31 0.34 27 45070 61 5 48 8 61
ASE_00270 0.64 0.63 0.66 81 72267 43 8 34 1 47
ASE_00274 0.48 0.47 0.51 48 55516 47 7 40 0 55
ASE_00277 0.38 0.38 0.38 35 48113 59 9 48 2 56
ASE_00279 0.70 0.66 0.74 67 53210 28 0 24 4 34
ASE_00285 0.71 0.67 0.75 82 68897 35 2 25 8 40
ASE_00287 0.72 0.67 0.77 69 54856 30 2 19 9 34
ASE_00294 0.79 0.75 0.83 128 114327 29 3 23 3 43
ASE_00295 0.53 0.49 0.57 64 73808 51 5 43 3 67
ASE_00298 0.47 0.45 0.50 51 67425 57 7 45 5 62
ASE_00318 0.63 0.60 0.65 71 80091 42 13 25 4 47
ASE_00335 0.48 0.47 0.50 54 75357 62 5 50 7 62
ASE_00339 0.53 0.52 0.53 62 80084 66 5 49 12 57
ASE_00340 0.75 0.74 0.76 63 45973 29 6 14 9 22
ASE_00343 0.31 0.31 0.31 35 83322 95 9 70 16 78
ASE_00367 0.32 0.34 0.31 29 42978 64 8 56 0 57
ASE_00370 0.65 0.63 0.67 53 41826 27 5 21 1 31
ASE_00372 0.70 0.69 0.72 69 51907 31 5 22 4 31
ASE_00375 0.57 0.54 0.60 59 60280 44 6 33 5 51
ASE_00376 0.52 0.50 0.54 53 56855 48 4 41 3 52
ASE_00377 0.68 0.66 0.70 71 57529 37 4 26 7 36
ASE_00386 0.53 0.53 0.53 51 50306 51 4 42 5 45
ASE_00393 0.37 0.35 0.39 33 47811 57 2 49 6 60
ASE_00412 0.46 0.45 0.48 47 58214 51 8 42 1 58
ASE_00413 0.39 0.42 0.36 34 44457 60 14 46 0 47
ASE_00416 0.69 0.67 0.72 85 77303 41 3 30 8 42
ASE_00417 0.36 0.37 0.35 37 54508 73 10 60 3 63
ASE_00422 0.70 0.68 0.72 64 46882 33 5 20 8 30
ASE_00428 0.53 0.51 0.55 64 76520 56 5 47 4 61
ASE_00429 - 0.39 0.38 0.41 25 28142 44 1 35 8 41
ASE_00430 0.63 0.62 0.65 60 46879 40 5 27 8 37
ASE_00434 0.57 0.55 0.58 61 68160 52 8 36 8 49
ASE_00437 0.42 0.40 0.44 54 79277 70 4 66 0 81
ASE_00451 0.49 0.46 0.52 58 70765 56 3 50 3 67
CRW_00648 - 0.60 0.64 0.57 94 137910 74 18 53 3 54
CRW_00654 - 0.70 0.68 0.72 84 78093 38 4 29 5 40
CRW_00658 - 0.45 0.46 0.45 47 74586 62 20 38 4 55
CRW_00663 - 0.14 0.15 0.13 9 26039 60 7 51 2 52
CRW_00664 - 0.05 0.05 0.04 4 53534 93 21 69 3 74
CRW_00671 0.60 0.59 0.61 69 62722 49 6 38 5 48
CRW_00672 0.48 0.50 0.47 55 72273 65 19 43 3 56
CRW_00674 0.53 0.53 0.52 66 83310 62 12 48 2 58
CRW_00676 0.54 0.56 0.52 64 93406 74 17 41 16 51
CRW_00685 - 0.38 0.42 0.34 44 156951 121 20 65 36 62
CRW_00688 - 0.85 0.86 0.84 49 21887 12 0 9 3 8
CRW_00721 - 0.52 0.60 0.46 41 58563 64 19 30 15 27
PDB_00078 - 0.47 0.45 0.50 52 49665 53 6 47 0 63
PDB_00278 - 0.12 0.13 0.12 9 24899 68 5 63 0 63
PDB_00571 0.17 0.16 0.19 4 3300 17 6 11 0 21
PDB_00701 - 0.47 0.46 0.49 50 45349 53 5 47 1 59
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00851 - 0.44 0.39 0.50 16 4721 16 0 16 0 25
PDB_00917 - 0.49 0.47 0.51 45 35157 49 4 39 6 50
PDB_01009 0.52 0.57 0.48 12 2460 13 5 8 0 9
RFA_00770 0.68 0.56 0.83 10 2004 5 0 2 3 8
RFA_00773 0.55 0.56 0.56 10 1935 8 2 6 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 18 2 13 3 16
TMR_00036 0.58 0.58 0.58 59 90423 73 10 33 30 42
TMR_00123 0.49 0.49 0.51 49 66333 53 10 38 5 52
TMR_00180 0.59 0.60 0.58 59 67060 53 7 35 11 40
TMR_00240 0.21 0.24 0.20 20 63088 85 23 59 3 65
TMR_00352 0.56 0.60 0.52 45 95179 80 17 25 38 30
TMR_00353 0.43 0.43 0.44 45 84152 74 15 43 16 60
TMR_00357 0.40 0.41 0.39 38 82931 75 22 37 16 54
TMR_00361 - 0.35 0.42 0.30 30 93428 88 29 41 18 42
TMR_00374 0.26 0.28 0.23 26 81699 88 23 62 3 66
TMR_00384 0.32 0.31 0.32 34 65597 78 6 66 6 74
TMR_00395 0.37 0.36 0.38 39 64517 68 5 59 4 70
TMR_00398 0.67 0.65 0.69 69 65241 37 2 29 6 37
TMR_00399 0.16 0.17 0.15 16 64871 97 27 66 4 78
TMR_00430 0.20 0.22 0.19 24 82495 102 23 79 0 85
TMR_00431 0.68 0.69 0.68 38 51947 63 8 10 45 17
TMR_00443 0.44 0.44 0.44 46 67057 60 14 44 2 58
TMR_00457 0.50 0.50 0.50 51 78504 58 12 39 7 51
TMR_00469 0.39 0.41 0.38 41 64511 68 11 57 0 59
TMR_00502 0.35 0.38 0.32 35 75358 83 17 56 10 58
TMR_00503 0.39 0.38 0.41 42 67794 68 5 55 8 69
TMR_00519 0.14 0.15 0.13 14 63083 103 16 77 10 81
TMR_00528 0.13 0.13 0.12 13 63081 106 12 84 10 84
TMR_00541 0.51 0.50 0.51 53 61672 59 5 46 8 52
TMR_00547 0.51 0.50 0.52 50 65245 48 3 43 2 50
TMR_00562 0.26 0.26 0.25 27 72665 88 13 66 9 75
TMR_00566 0.53 0.52 0.54 52 60629 54 5 40 9 48
TMR_00571 0.59 0.60 0.58 59 60624 48 8 35 5 40
TMR_00584 0.40 0.42 0.38 41 60967 73 8 59 6 56
TMR_00594 0.22 0.22 0.22 23 79295 88 14 69 5 81
TMR_00605 0.49 0.50 0.49 54 74194 58 21 36 1 54
TMR_00609 0.67 0.67 0.67 76 63433 39 8 29 2 37
TMR_00624 0.51 0.51 0.51 55 62373 65 5 48 12 53
TMR_00683 0.33 0.35 0.32 35 82917 79 17 59 3 65
TMR_00698 0.36 0.36 0.36 37 63087 69 17 49 3 67
TMR_00703 0.31 0.31 0.30 31 67426 75 14 57 4 68
TMR_00706 0.52 0.51 0.52 53 66328 53 6 43 4 50
TMR_00711 0.58 0.58 0.58 57 67797 46 14 28 4 41

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 2258
Total TN 6805326
Total FP 13384
Total FP CONTRA 2402
Total FP INCONS 10499
Total FP COMP 483
Total FN 8674
Total Scores
MCC 0.174
Average MCC ± 95% Confidence Intervals 0.183 ± 0.028
Sensitivity 0.207
Positive Predictive Value 0.149
Nr of predictions 112

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.02 0.03 0.02 2 50914 131 38 86 7 62
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00122 0.27 0.30 0.24 26 43258 84 13 68 3 62
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00196 0.49 0.57 0.42 43 31524 62 16 43 3 32
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00227 0.28 0.31 0.25 41 78840 122 20 102 0 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00231 0.37 0.42 0.33 40 47773 84 17 65 2 56
ASE_00234 0.25 0.27 0.23 35 75315 117 10 106 1 94
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00248 0.13 0.15 0.12 17 62340 124 9 115 0 97
ASE_00250 0.25 0.29 0.23 38 78835 135 17 113 5 93
ASE_00254 0.15 0.16 0.14 13 36761 88 3 79 6 69
ASE_00255 0.11 0.12 0.10 16 74530 146 16 129 1 114
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00274 0.00 0.00 0.00 0 55487 126 12 112 2 103
ASE_00277 0.10 0.12 0.08 11 48071 123 23 100 0 80
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00287 0.15 0.17 0.14 17 54824 107 14 91 2 86
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00295 0.14 0.16 0.13 21 73761 140 19 119 2 110
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00318 0.03 0.04 0.03 5 80039 156 21 135 0 113
ASE_00335 0.10 0.12 0.09 14 75304 151 22 126 3 102
ASE_00339 0.25 0.29 0.22 34 80042 129 20 104 5 85
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00343 0.14 0.17 0.12 19 83275 145 31 111 3 94
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00370 0.03 0.04 0.03 3 41796 109 18 88 3 81
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00375 0.12 0.14 0.11 15 60246 120 10 107 3 95
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00377 0.25 0.27 0.23 29 57505 98 10 86 2 78
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00413 0.08 0.10 0.07 8 44438 108 19 86 3 73
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00417 0.32 0.36 0.28 36 54486 98 18 75 5 64
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00429 - 0.08 0.09 0.07 6 28114 84 14 69 1 60
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00434 0.29 0.34 0.25 37 68116 122 20 92 10 73
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
CRW_00648 - 0.05 0.06 0.04 9 137864 213 24 178 11 139
CRW_00654 - 0.41 0.47 0.36 58 78049 105 18 85 2 66
CRW_00658 - 0.21 0.26 0.16 27 74527 137 28 109 0 75
CRW_00663 - 0.08 0.10 0.07 6 26014 90 17 69 4 55
CRW_00664 - 0.14 0.19 0.11 15 53486 134 42 85 7 63
CRW_00671 0.18 0.21 0.16 24 62682 130 23 106 1 93
CRW_00672 0.36 0.43 0.31 48 72233 114 35 74 5 63
CRW_00674 0.16 0.19 0.14 23 83274 142 19 120 3 101
CRW_00676 0.11 0.14 0.09 16 93347 169 29 136 4 99
CRW_00685 - 0.11 0.15 0.08 16 156867 212 64 133 15 90
CRW_00688 - 0.33 0.40 0.27 23 21859 64 21 42 1 34
CRW_00721 - 0.22 0.31 0.15 21 58515 133 46 71 16 47
PDB_00078 - 0.00 0.00 0.00 0 49644 126 10 116 0 115
PDB_00278 - 0.04 0.06 0.04 4 24875 98 13 84 1 68
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00701 - 0.04 0.05 0.04 5 45319 127 14 113 0 104
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_00851 - 0.16 0.17 0.17 7 4711 35 3 32 0 34
PDB_00917 - 0.31 0.34 0.29 32 35136 81 10 67 4 63
PDB_01009 0.27 0.33 0.23 7 2455 25 3 20 2 14
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0
TMR_00036 0.22 0.29 0.17 29 90359 153 37 100 16 72
TMR_00123 0.19 0.23 0.16 23 66283 126 20 104 2 78
TMR_00180 0.12 0.16 0.10 16 66999 149 35 111 3 83
TMR_00240 0.23 0.31 0.17 26 63041 128 39 84 5 59
TMR_00352 0.07 0.09 0.05 7 95133 171 39 87 45 68
TMR_00353 0.41 0.51 0.32 54 84087 127 49 65 13 51
TMR_00357 0.26 0.34 0.19 31 82869 146 44 84 18 61
TMR_00361 - 0.06 0.10 0.04 7 93368 174 64 89 21 65
TMR_00374 0.09 0.13 0.07 12 81631 174 44 123 7 80
TMR_00384 0.17 0.20 0.14 22 65550 133 26 105 2 86
TMR_00395 0.27 0.31 0.24 34 64478 115 10 98 7 75
TMR_00398 0.05 0.07 0.05 7 65197 139 24 113 2 99
TMR_00399 0.20 0.26 0.16 24 64833 130 38 85 7 70
TMR_00430 0.18 0.23 0.15 25 82450 148 34 112 2 84
TMR_00431 0.24 0.33 0.17 18 51899 127 26 60 41 37
TMR_00443 0.17 0.20 0.15 21 67018 126 24 98 4 83
TMR_00457 0.19 0.25 0.15 25 78443 141 39 99 3 77
TMR_00469 0.10 0.12 0.08 12 64469 145 27 112 6 88
TMR_00502 0.14 0.19 0.11 18 75303 150 45 100 5 75
TMR_00503 0.11 0.14 0.10 15 67741 141 20 120 1 96
TMR_00519 0.04 0.05 0.03 5 63046 141 33 106 2 90
TMR_00528 0.13 0.15 0.11 15 63051 131 20 104 7 82
TMR_00541 0.12 0.14 0.10 15 61630 139 22 109 8 90
TMR_00547 0.28 0.35 0.23 35 65188 122 37 81 4 65
TMR_00562 0.09 0.12 0.08 12 72617 147 27 115 5 90
TMR_00566 0.13 0.16 0.11 16 60582 132 22 106 4 84
TMR_00571 0.05 0.06 0.04 6 60577 149 19 124 6 93
TMR_00584 0.01 0.01 0.01 1 60922 159 33 119 7 96
TMR_00594 0.08 0.10 0.06 10 79238 156 30 123 3 94
TMR_00605 0.28 0.35 0.23 38 74141 129 36 90 3 70
TMR_00609 0.53 0.62 0.45 70 63391 89 28 57 4 43
TMR_00624 0.36 0.44 0.30 47 62325 111 27 82 2 61
TMR_00683 0.01 0.02 0.01 2 82854 176 50 122 4 98
TMR_00698 0.20 0.24 0.17 25 63042 124 27 96 1 79
TMR_00703 0.10 0.12 0.08 12 67376 140 26 114 0 87
TMR_00706 0.14 0.17 0.11 17 66281 133 29 103 1 86
TMR_00711 0.18 0.22 0.14 22 67740 137 41 93 3 76

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.