CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAshapes		CMfinder(seed)
MCC	0.540	>	0.359
Average MCC ± 95% Confidence Intervals	0.501 ± 0.092	>	0.398 ± 0.088
Sensitivity	0.531	>	0.186
Positive Predictive Value	0.550	<	0.698
Total TP	822	>	287
Total TN	843580	<	844664
Total FP	779	>	125
Total FP CONTRA	104	>	6
Total FP INCONS	569	>	118
Total FP COMP	106	>	1
Total FN	725	<	1260
P-value	5.1503931209e-08

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Performance plots

Comparison of performance of RNAshapes and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP	822
Total TN	843580
Total FP	779
Total FP CONTRA	104
Total FP INCONS	569
Total FP COMP	106
Total FN	725

Total Scores
MCC	0.540
Average MCC ± 95% Confidence Intervals	0.501 ± 0.092
Sensitivity	0.531
Positive Predictive Value	0.550
Nr of predictions	24

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.49	0.48	0.51	57	77309	66	7	48	11	63
CRW_00610	Intron_gpI links to Rfam database...	0.55	0.53	0.57	43	36240	37	3	29	5	38
CRW_00613	Intron_gpI links to Rfam database...	0.64	0.58	0.70	45	34916	28	1	18	9	33
CRW_00618	Intron_gpI links to Rfam database...	0.17	0.18	0.16	11	56213	77	9	47	21	50
CRW_00633	Intron_gpI links to Rfam database...	0.55	0.54	0.56	57	63445	45	8	36	1	49
CRW_00634	Intron_gpI links to Rfam database...	0.33	0.34	0.33	32	64522	75	8	58	9	62
CRW_00670	Intron_gpI links to Rfam database...	0.74	0.72	0.76	86	70012	32	0	27	5	34
CRW_00671	Intron_gpI links to Rfam database...	0.65	0.62	0.67	73	62726	43	1	35	7	44
CRW_00672	Intron_gpI links to Rfam database...	0.66	0.66	0.66	73	72279	45	8	30	7	38
CRW_00674	Intron_gpI links to Rfam database...	0.68	0.67	0.69	83	83316	41	6	31	4	41
CRW_00676	Intron_gpI links to Rfam database...	0.58	0.62	0.55	71	93398	67	17	42	8	44
CRW_00692	Intron_gpI links to Rfam database...	0.43	0.46	0.40	41	68533	70	18	43	9	49
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2678	24	1	22	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.64	0.56	0.74	45	26967	17	0	16	1	36
PDB_01092	glmS links to Rfam database...	0.54	0.50	0.58	26	10108	21	2	17	2	26
RFA_00632	HDV_ribozyme links to Rfam database...	0.34	0.36	0.33	10	4065	20	2	18	0	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00769	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1934	9	4	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	2001	8	0	5	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	4	1	0	3	8
RFA_00779	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	15	2	13	0	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	11	1	10	0	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	287
Total TN	844664
Total FP	125
Total FP CONTRA	6
Total FP INCONS	118
Total FP COMP	1
Total FN	1260

Total Scores
MCC	0.359
Average MCC ± 95% Confidence Intervals	0.398 ± 0.088
Sensitivity	0.186
Positive Predictive Value	0.698
Nr of predictions	24

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

2. Individual counts for RNAshapes [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]