CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Vsfold4		CMfinder(seed)
MCC	0.402	>	0.359
Average MCC ± 95% Confidence Intervals	0.414 ± 0.087	>	0.398 ± 0.088
Sensitivity	0.370	>	0.186
Positive Predictive Value	0.439	<	0.698
Total TP	572	>	287
Total TN	843771	<	844664
Total FP	800	>	125
Total FP CONTRA	117	>	6
Total FP INCONS	615	>	118
Total FP COMP	68	>	1
Total FN	975	<	1260
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of Vsfold4 and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and CMfinder(seed)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	572
Total TN	843771
Total FP	800
Total FP CONTRA	117
Total FP INCONS	615
Total FP COMP	68
Total FN	975

Total Scores
MCC	0.402
Average MCC ± 95% Confidence Intervals	0.414 ± 0.087
Sensitivity	0.370
Positive Predictive Value	0.439
Nr of predictions	24

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.53	0.46	0.61	55	77331	44	4	31	9	65
CRW_00610	Intron_gpI links to Rfam database...	0.40	0.36	0.46	29	36252	37	5	29	3	52
CRW_00613	Intron_gpI links to Rfam database...	0.48	0.42	0.54	33	34919	34	2	26	6	45
CRW_00618	Intron_gpI links to Rfam database...	0.33	0.31	0.35	19	56225	57	6	30	21	42
CRW_00633	Intron_gpI links to Rfam database...	0.38	0.35	0.42	37	63457	52	6	46	0	69
CRW_00634	Intron_gpI links to Rfam database...	0.29	0.28	0.30	26	64533	68	8	53	7	68
CRW_00670	Intron_gpI links to Rfam database...	0.37	0.34	0.41	41	70025	60	3	56	1	79
CRW_00671	Intron_gpI links to Rfam database...	0.55	0.50	0.60	59	62736	40	2	38	0	58
CRW_00672	Intron_gpI links to Rfam database...	0.30	0.29	0.32	32	72291	71	14	53	4	79
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.26	0.33	32	83339	67	8	57	2	92
CRW_00676	Intron_gpI links to Rfam database...	0.34	0.34	0.34	39	93413	80	20	56	4	76
CRW_00692	Intron_gpI links to Rfam database...	0.26	0.24	0.28	22	68555	62	20	38	4	68
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.84	0.71	1.00	10	936	0	0	0	0	4
PDB_00716	HDV_ribozyme links to Rfam database...	0.17	0.17	0.18	4	2679	19	0	18	1	19
PDB_00827	Intron_gpI links to Rfam database...	0.65	0.54	0.79	44	26972	13	0	12	1	37
PDB_01092	glmS links to Rfam database...	0.66	0.58	0.77	30	10114	10	2	7	1	22
RFA_00632	HDV_ribozyme links to Rfam database...	0.36	0.36	0.37	10	4068	17	3	14	0	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.58	0.57	0.59	16	3978	11	1	10	0	12
RFA_00769	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	4	5	0	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	2003	15	2	11	2	18
RFA_00773	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1936	19	1	16	2	18
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	2	1	0	8
RFA_00808	RydC links to Rfam database...	0.62	0.56	0.69	9	2003	4	3	1	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	287
Total TN	844664
Total FP	125
Total FP CONTRA	6
Total FP INCONS	118
Total FP COMP	1
Total FN	1260

Total Scores
MCC	0.359
Average MCC ± 95% Confidence Intervals	0.398 ± 0.088
Sensitivity	0.186
Positive Predictive Value	0.698
Nr of predictions	24

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]