CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Afold		MXScarna(seed)
MCC	0.517	>	0.488
Average MCC ± 95% Confidence Intervals	0.507 ± 0.168	>	0.470 ± 0.168
Sensitivity	0.480	>	0.464
Positive Predictive Value	0.564	>	0.522
Total TP	146	>	141
Total TN	39323	>	39312
Total FP	134	<	136
Total FP CONTRA	12	<	21
Total FP INCONS	101	<	108
Total FP COMP	21	>	7
Total FN	158	<	163
P-value	1.70887622364e-08

Comparison of performance of Afold and MXScarna(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and MXScarna(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and MXScarna(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and MXScarna(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and MXScarna(seed)).

Total Scores
MCC	0.517
Average MCC ± 95% Confidence Intervals	0.507 ± 0.168
Sensitivity	0.480
Positive Predictive Value	0.564
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2677	25	1	23	1	23
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00829	Purine links to Rfam database...	0.82	0.71	0.94	17	2260	1	0	1	0	7
PDB_01092	glmS links to Rfam database...	0.69	0.60	0.79	31	10114	11	1	7	3	21
RFA_00632	HDV_ribozyme links to Rfam database...	0.40	0.39	0.41	11	4068	18	0	16	2	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	17	2	14	1	16
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	5	0	4	1	8
RFA_00768	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	8	1	6	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	10	3	5	2	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	12	1	10	1	10

Total Scores
MCC	0.488
Average MCC ± 95% Confidence Intervals	0.470 ± 0.168
Sensitivity	0.464
Positive Predictive Value	0.522
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2681	21	1	19	1	23
PDB_00828	Purine links to Rfam database...	0.82	0.67	1.00	18	2467	0	0	0	0	9
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01092	glmS links to Rfam database...	0.70	0.63	0.79	33	10111	12	2	7	3	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.25	0.25	0.27	7	4069	19	1	18	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.35	0.36	0.36	10	3977	18	2	16	0	18
RFA_00767	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	2	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	2	4	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.57	0.56	0.59	10	1999	7	2	5	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2000	19	2	14	3	16
RFA_00809	RydC links to Rfam database...	0.30	0.31	0.29	5	2128	12	1	11	0	11

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.