CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CentroidFold		RSpredict(seed)
MCC	0.695	>	0.514
Average MCC ± 95% Confidence Intervals	0.690 ± 0.085	>	0.515 ± 0.084
Sensitivity	0.608	>	0.427
Positive Predictive Value	0.799	>	0.625
Total TP	239	>	168
Total TN	48831	<	48861
Total FP	69	<	105
Total FP CONTRA	11	<	41
Total FP INCONS	49	<	60
Total FP COMP	9	>	4
Total FN	154	<	225
P-value	3.36130997681e-08

Comparison of performance of CentroidFold and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and RSpredict(seed)).

Total Scores
MCC	0.695
Average MCC ± 95% Confidence Intervals	0.690 ± 0.085
Sensitivity	0.608
Positive Predictive Value	0.799
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.33	0.30	0.37	7	2682	13	0	12	1	16
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.86	0.74	1.00	25	4346	1	0	0	1	9
PDB_01092	glmS links to Rfam database...	0.71	0.63	0.80	33	10112	10	1	7	2	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.67	0.61	0.74	17	4072	6	1	5	0	11
RFA_00636	HDV_ribozyme links to Rfam database...	0.64	0.64	0.64	18	3977	10	4	6	0	10
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.45	0.44	0.47	8	1874	9	1	8	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.64	0.50	0.82	9	2005	4	0	2	2	9
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	3	1	0	2	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	0	2	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.43	0.38	0.50	6	2133	6	0	6	0	10

Total Scores
MCC	0.514
Average MCC ± 95% Confidence Intervals	0.515 ± 0.084
Sensitivity	0.427
Positive Predictive Value	0.625
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.71	0.57	0.89	8	937	1	0	1	0	6
PDB_00716	HDV_ribozyme links to Rfam database...	0.59	0.48	0.73	11	2686	4	0	4	0	12
PDB_00828	Purine links to Rfam database...	0.54	0.41	0.73	11	2470	4	2	2	0	16
PDB_00829	Purine links to Rfam database...	0.74	0.63	0.88	15	2261	2	2	0	0	9
PDB_01020	Purine links to Rfam database...	0.76	0.65	0.88	15	2261	2	2	0	0	8
PDB_01073	SAM links to Rfam database...	0.39	0.18	0.86	6	4364	1	0	1	0	28
PDB_01092	glmS links to Rfam database...	0.48	0.37	0.63	19	10123	13	1	10	2	33
RFA_00632	HDV_ribozyme links to Rfam database...	0.47	0.39	0.58	11	4076	8	3	5	0	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.62	0.54	0.71	15	3984	6	3	3	0	13
RFA_00767	Corona_pk3 links to Rfam database...	0.19	0.17	0.23	3	1878	10	3	7	0	15
RFA_00768	Corona_pk3 links to Rfam database...	0.19	0.17	0.23	3	1878	10	3	7	0	15
RFA_00769	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	4	2	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1997	9	6	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00779	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00808	RydC links to Rfam database...	0.60	0.50	0.73	8	2005	4	0	3	1	8
RFA_00809	RydC links to Rfam database...	0.37	0.31	0.45	5	2134	7	0	6	1	11

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.