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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & NanoFolder [.zip] - may take several seconds...


Overview

Metric Cylofold NanoFolder
MCC 0.784 > 0.242
Average MCC ± 95% Confidence Intervals 0.827 ± 0.197 > 0.273 ± 0.363
Sensitivity 0.720 > 0.273
Positive Predictive Value 0.857 > 0.228
Total TP 108 > 41
Total TN 16887 > 16833
Total FP 27 < 152
Total FP CONTRA 2 < 15
Total FP INCONS 16 < 124
Total FP COMP 9 < 13
Total FN 42 < 109
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and NanoFolder).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 108
Total TN 16887
Total FP 27
Total FP CONTRA 2
Total FP INCONS 16
Total FP COMP 9
Total FN 42
Total Scores
MCC 0.784
Average MCC ± 95% Confidence Intervals 0.827 ± 0.197
Sensitivity 0.720
Positive Predictive Value 0.857
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00851 - 0.45 0.39 0.53 16 4723 14 0 14 0 25
PDB_01009 0.90 0.90 0.90 19 2464 5 0 2 3 2
RFA_00770 0.88 0.78 1.00 14 2002 3 0 0 3 4
RFA_00773 0.97 1.00 0.95 18 1934 4 1 0 3 0

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 41
Total TN 16833
Total FP 152
Total FP CONTRA 15
Total FP INCONS 124
Total FP COMP 13
Total FN 109
Total Scores
MCC 0.242
Average MCC ± 95% Confidence Intervals 0.273 ± 0.363
Sensitivity 0.273
Positive Predictive Value 0.228
Nr of predictions 6

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_00851 - 0.16 0.17 0.17 7 4711 35 3 32 0 34
PDB_01009 0.27 0.33 0.23 7 2455 25 3 20 2 14
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.