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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Vsfold4 [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Vsfold4
MCC 0.837 > 0.784
Average MCC ± 95% Confidence Intervals 0.841 ± 0.068 > 0.800 ± 0.177
Sensitivity 0.752 > 0.684
Positive Predictive Value 0.935 > 0.901
Total TP 100 > 91
Total TN 14626 < 14632
Total FP 9 < 12
Total FP CONTRA 2 > 1
Total FP INCONS 5 < 9
Total FP COMP 2 = 2
Total FN 33 < 42
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(20) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Vsfold4).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 100
Total TN 14626
Total FP 9
Total FP CONTRA 2
Total FP INCONS 5
Total FP COMP 2
Total FN 33
Total Scores
MCC 0.837
Average MCC ± 95% Confidence Intervals 0.841 ± 0.068
Sensitivity 0.752
Positive Predictive Value 0.935
Nr of predictions 5

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.76 0.68 0.85 17 3301 3 1 2 0 8
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.89 0.79 1.00 19 2259 0 0 0 0 5
PDB_01020 0.88 0.78 1.00 18 2260 0 0 0 0 5
PDB_01073 0.81 0.76 0.87 26 4341 6 1 3 2 8

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 91
Total TN 14632
Total FP 12
Total FP CONTRA 1
Total FP INCONS 9
Total FP COMP 2
Total FN 42
Total Scores
MCC 0.784
Average MCC ± 95% Confidence Intervals 0.800 ± 0.177
Sensitivity 0.684
Positive Predictive Value 0.901
Nr of predictions 5

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.55 0.47 0.64 16 4346 10 0 9 1 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.