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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of CRWrnafold - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & CRWrnafold [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) CRWrnafold
MCC 0.539 > 0.527
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138 > 0.512 ± 0.153
Sensitivity 0.501 > 0.491
Positive Predictive Value 0.586 > 0.573
Total TP 197 > 193
Total TN 48794 > 48793
Total FP 147 < 157
Total FP CONTRA 24 > 21
Total FP INCONS 115 < 123
Total FP COMP 8 < 13
Total FN 196 < 200
P-value 5.95320262584e-05

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Performance plots


  1. Comparison of performance of MXScarna(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and CRWrnafold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and CRWrnafold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and CRWrnafold).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 197
Total TN 48794
Total FP 147
Total FP CONTRA 24
Total FP INCONS 115
Total FP COMP 8
Total FN 196
Total Scores
MCC 0.539
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138
Sensitivity 0.501
Positive Predictive Value 0.586
Nr of predictions 17

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00716 -0.01 0.00 0.00 0 2681 21 1 19 1 23
PDB_00828 0.82 0.67 1.00 18 2467 0 0 0 0 9
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.81 0.74 0.89 25 4343 4 1 2 1 9
PDB_01092 0.70 0.63 0.79 33 10111 12 2 7 3 19
RFA_00632 0.25 0.25 0.27 7 4069 19 1 18 0 21
RFA_00636 0.35 0.36 0.36 10 3977 18 2 16 0 18
RFA_00767 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00768 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.57 0.56 0.59 10 1999 7 2 5 0 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00779 0.57 0.56 0.59 10 1936 7 2 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 19 2 14 3 16
RFA_00809 0.30 0.31 0.29 5 2128 12 1 11 0 11

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 193
Total TN 48793
Total FP 157
Total FP CONTRA 21
Total FP INCONS 123
Total FP COMP 13
Total FN 200
Total Scores
MCC 0.527
Average MCC ± 95% Confidence Intervals 0.512 ± 0.153
Sensitivity 0.491
Positive Predictive Value 0.573
Nr of predictions 17

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00716 -0.01 0.00 0.00 0 2680 22 0 21 1 23
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.52 0.47 0.59 16 4344 12 1 10 1 18
PDB_01092 0.68 0.62 0.76 32 10111 12 1 9 2 20
RFA_00632 0.37 0.36 0.38 10 4069 19 0 16 3 18
RFA_00636 0.51 0.50 0.52 14 3978 13 3 10 0 14
RFA_00767 0.59 0.56 0.63 10 1875 6 3 3 0 8
RFA_00768 0.47 0.44 0.50 8 1875 8 1 7 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 -0.01 0.00 0.00 0 2002 17 1 13 3 18
RFA_00773 0.59 0.56 0.63 10 1937 6 1 5 0 8
RFA_00779 0.59 0.56 0.63 10 1937 6 3 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 18 2 14 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.