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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Mastr(seed)
MCC 0.539 > 0.341
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138 > 0.295 ± 0.170
Sensitivity 0.501 > 0.176
Positive Predictive Value 0.586 < 0.670
Total TP 197 > 69
Total TN 48794 < 49027
Total FP 147 > 37
Total FP CONTRA 24 > 5
Total FP INCONS 115 > 29
Total FP COMP 8 > 3
Total FN 196 < 324
P-value 1.43692248862e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Mastr(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 197
Total TN 48794
Total FP 147
Total FP CONTRA 24
Total FP INCONS 115
Total FP COMP 8
Total FN 196
Total Scores
MCC 0.539
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138
Sensitivity 0.501
Positive Predictive Value 0.586
Nr of predictions 17

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00716 -0.01 0.00 0.00 0 2681 21 1 19 1 23
PDB_00828 0.82 0.67 1.00 18 2467 0 0 0 0 9
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.81 0.74 0.89 25 4343 4 1 2 1 9
PDB_01092 0.70 0.63 0.79 33 10111 12 2 7 3 19
RFA_00632 0.25 0.25 0.27 7 4069 19 1 18 0 21
RFA_00636 0.35 0.36 0.36 10 3977 18 2 16 0 18
RFA_00767 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00768 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.57 0.56 0.59 10 1999 7 2 5 0 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00779 0.57 0.56 0.59 10 1936 7 2 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 19 2 14 3 16
RFA_00809 0.30 0.31 0.29 5 2128 12 1 11 0 11

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 69
Total TN 49027
Total FP 37
Total FP CONTRA 5
Total FP INCONS 29
Total FP COMP 3
Total FN 324
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.295 ± 0.170
Sensitivity 0.176
Positive Predictive Value 0.670
Nr of predictions 17

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
PDB_00829 0.00 0.00 0.00 0 2278 0 0 0 0 24
PDB_01020 0.00 0.00 0.00 0 2278 0 0 0 0 23
PDB_01073 0.00 0.00 0.00 0 4371 0 0 0 0 34
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00767 0.67 0.50 0.90 9 1881 1 0 1 0 9
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.