CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	MXScarna(seed)		RNAwolf
MCC	0.539	>	0.487
Average MCC ± 95% Confidence Intervals	0.525 ± 0.138	>	0.502 ± 0.103
Sensitivity	0.501	>	0.461
Positive Predictive Value	0.586	>	0.523
Total TP	197	>	181
Total TN	48794	>	48784
Total FP	147	<	189
Total FP CONTRA	24	<	26
Total FP INCONS	115	<	139
Total FP COMP	8	<	24
Total FN	196	<	212
P-value	5.23753225208e-08

Comparison of performance of MXScarna(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and RNAwolf).

Total Scores
MCC	0.539
Average MCC ± 95% Confidence Intervals	0.525 ± 0.138
Sensitivity	0.501
Positive Predictive Value	0.586
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.59	0.36	1.00	5	941	0	0	0	0	9
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2681	21	1	19	1	23
PDB_00828	Purine links to Rfam database...	0.82	0.67	1.00	18	2467	0	0	0	0	9
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.83	0.70	1.00	16	2262	0	0	0	0	7
PDB_01073	SAM links to Rfam database...	0.81	0.74	0.89	25	4343	4	1	2	1	9
PDB_01092	glmS links to Rfam database...	0.70	0.63	0.79	33	10111	12	2	7	3	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.25	0.25	0.27	7	4069	19	1	18	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.35	0.36	0.36	10	3977	18	2	16	0	18
RFA_00767	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	2	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	2	4	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.57	0.56	0.59	10	1999	7	2	5	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.57	0.56	0.59	10	1936	7	2	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2000	19	2	14	3	16
RFA_00809	RydC links to Rfam database...	0.30	0.31	0.29	5	2128	12	1	11	0	11

Total Scores
MCC	0.487
Average MCC ± 95% Confidence Intervals	0.502 ± 0.103
Sensitivity	0.461
Positive Predictive Value	0.523
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.42	0.36	0.50	5	936	6	0	5	1	9
PDB_00716	HDV_ribozyme links to Rfam database...	0.68	0.57	0.81	13	2685	3	0	3	0	10
PDB_00828	Purine links to Rfam database...	0.85	0.81	0.88	22	2460	3	1	2	0	5
PDB_00829	Purine links to Rfam database...	0.78	0.75	0.82	18	2256	4	1	3	0	6
PDB_01020	Purine links to Rfam database...	0.84	0.83	0.86	19	2256	5	1	2	2	4
PDB_01073	SAM links to Rfam database...	0.17	0.18	0.17	6	4336	29	3	26	0	28
PDB_01092	glmS links to Rfam database...	0.43	0.38	0.49	20	10112	23	2	19	2	32
RFA_00632	HDV_ribozyme links to Rfam database...	0.25	0.25	0.27	7	4069	22	1	18	3	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.40	0.39	0.41	11	3978	19	1	15	3	17
RFA_00767	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	8	1	6	1	10
RFA_00768	Corona_pk3 links to Rfam database...	0.50	0.44	0.57	8	1877	8	1	5	2	10
RFA_00769	Corona_pk3 links to Rfam database...	0.41	0.44	0.38	8	1932	13	3	10	0	10
RFA_00770	Corona_pk3 links to Rfam database...	0.51	0.50	0.53	9	1999	12	2	6	4	9
RFA_00773	Corona_pk3 links to Rfam database...	0.42	0.39	0.47	7	1938	12	1	7	4	11
RFA_00779	Corona_pk3 links to Rfam database...	0.26	0.28	0.26	5	1934	14	6	8	0	13
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	2	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	6	0	4	2	10

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.