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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Vsfold4 [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Vsfold4
MCC 0.539 > 0.488
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138 > 0.463 ± 0.169
Sensitivity 0.501 > 0.445
Positive Predictive Value 0.586 > 0.543
Total TP 197 > 175
Total TN 48794 < 48808
Total FP 147 < 155
Total FP CONTRA 24 > 21
Total FP INCONS 115 < 126
Total FP COMP 8 = 8
Total FN 196 < 218
P-value 1.49381627234e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold4).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 197
Total TN 48794
Total FP 147
Total FP CONTRA 24
Total FP INCONS 115
Total FP COMP 8
Total FN 196
Total Scores
MCC 0.539
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138
Sensitivity 0.501
Positive Predictive Value 0.586
Nr of predictions 17

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00716 -0.01 0.00 0.00 0 2681 21 1 19 1 23
PDB_00828 0.82 0.67 1.00 18 2467 0 0 0 0 9
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.81 0.74 0.89 25 4343 4 1 2 1 9
PDB_01092 0.70 0.63 0.79 33 10111 12 2 7 3 19
RFA_00632 0.25 0.25 0.27 7 4069 19 1 18 0 21
RFA_00636 0.35 0.36 0.36 10 3977 18 2 16 0 18
RFA_00767 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00768 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.57 0.56 0.59 10 1999 7 2 5 0 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00779 0.57 0.56 0.59 10 1936 7 2 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 19 2 14 3 16
RFA_00809 0.30 0.31 0.29 5 2128 12 1 11 0 11

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 175
Total TN 48808
Total FP 155
Total FP CONTRA 21
Total FP INCONS 126
Total FP COMP 8
Total FN 218
Total Scores
MCC 0.488
Average MCC ± 95% Confidence Intervals 0.463 ± 0.169
Sensitivity 0.445
Positive Predictive Value 0.543
Nr of predictions 17

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.84 0.71 1.00 10 936 0 0 0 0 4
PDB_00716 0.17 0.17 0.18 4 2679 19 0 18 1 19
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.55 0.47 0.64 16 4346 10 0 9 1 18
PDB_01092 0.66 0.58 0.77 30 10114 10 2 7 1 22
RFA_00632 0.36 0.36 0.37 10 4068 17 3 14 0 18
RFA_00636 0.58 0.57 0.59 16 3978 11 1 10 0 12
RFA_00767 -0.01 0.00 0.00 0 1878 13 1 12 0 18
RFA_00768 -0.01 0.00 0.00 0 1875 16 1 15 0 18
RFA_00769 0.50 0.50 0.50 9 1935 9 4 5 0 9
RFA_00770 -0.01 0.00 0.00 0 2003 15 2 11 2 18
RFA_00773 -0.01 0.00 0.00 0 1936 19 1 16 2 18
RFA_00779 0.65 0.56 0.77 10 1940 3 2 1 0 8
RFA_00808 0.62 0.56 0.69 9 2003 4 3 1 0 7
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.