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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Vsfold5 [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Vsfold5
MCC 0.539 > 0.531
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138 > 0.517 ± 0.170
Sensitivity 0.501 = 0.501
Positive Predictive Value 0.586 > 0.569
Total TP 197 = 197
Total TN 48794 > 48784
Total FP 147 < 155
Total FP CONTRA 24 = 24
Total FP INCONS 115 < 125
Total FP COMP 8 > 6
Total FN 196 = 196
P-value 0.00909249161262

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold5).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 197
Total TN 48794
Total FP 147
Total FP CONTRA 24
Total FP INCONS 115
Total FP COMP 8
Total FN 196
Total Scores
MCC 0.539
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138
Sensitivity 0.501
Positive Predictive Value 0.586
Nr of predictions 17

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00716 -0.01 0.00 0.00 0 2681 21 1 19 1 23
PDB_00828 0.82 0.67 1.00 18 2467 0 0 0 0 9
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.81 0.74 0.89 25 4343 4 1 2 1 9
PDB_01092 0.70 0.63 0.79 33 10111 12 2 7 3 19
RFA_00632 0.25 0.25 0.27 7 4069 19 1 18 0 21
RFA_00636 0.35 0.36 0.36 10 3977 18 2 16 0 18
RFA_00767 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00768 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.57 0.56 0.59 10 1999 7 2 5 0 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00779 0.57 0.56 0.59 10 1936 7 2 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 19 2 14 3 16
RFA_00809 0.30 0.31 0.29 5 2128 12 1 11 0 11

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 197
Total TN 48784
Total FP 155
Total FP CONTRA 24
Total FP INCONS 125
Total FP COMP 6
Total FN 196
Total Scores
MCC 0.531
Average MCC ± 95% Confidence Intervals 0.517 ± 0.170
Sensitivity 0.501
Positive Predictive Value 0.569
Nr of predictions 17

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.78 0.79 0.79 11 932 3 1 2 0 3
PDB_00716 0.17 0.17 0.18 4 2679 19 0 18 1 19
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.83 0.79 0.86 19 2256 3 2 1 0 5
PDB_01020 0.82 0.78 0.86 18 2257 4 2 1 1 5
PDB_01073 0.56 0.47 0.67 16 4347 9 1 7 1 18
PDB_01092 0.73 0.69 0.77 36 10106 12 2 9 1 16
RFA_00632 -0.01 0.00 0.00 0 4073 22 0 22 0 28
RFA_00636 0.58 0.57 0.59 16 3978 11 1 10 0 12
RFA_00767 0.21 0.22 0.22 4 1873 14 2 12 0 14
RFA_00768 -0.01 0.00 0.00 0 1875 16 1 15 0 18
RFA_00769 0.50 0.50 0.50 9 1935 9 4 5 0 9
RFA_00770 0.65 0.56 0.77 10 2003 3 3 0 0 8
RFA_00773 -0.01 0.00 0.00 0 1936 19 1 16 2 18
RFA_00779 0.69 0.61 0.79 11 1939 3 3 0 0 7
RFA_00808 1.00 1.00 1.00 16 2000 0 0 0 0 0
RFA_00809 0.45 0.44 0.47 7 2130 8 1 7 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.