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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Mastr(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Mastr(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Mastr(20) NanoFolder
MCC 0.456 > 0.144
Average MCC ± 95% Confidence Intervals 0.437 ± 5.638 > 0.145 ± 1.950
Sensitivity 0.404 > 0.173
Positive Predictive Value 0.525 > 0.134
Total TP 21 > 9
Total TN 5766 > 5739
Total FP 20 < 59
Total FP CONTRA 3 < 6
Total FP INCONS 16 < 52
Total FP COMP 1 = 1
Total FN 31 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Mastr(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(20) and NanoFolder).

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Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 21
Total TN 5766
Total FP 20
Total FP CONTRA 3
Total FP INCONS 16
Total FP COMP 1
Total FN 31
Total Scores
MCC 0.456
Average MCC ± 95% Confidence Intervals 0.437 ± 5.638
Sensitivity 0.404
Positive Predictive Value 0.525
Nr of predictions 2

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3302 20 3 16 1 25
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 9
Total TN 5739
Total FP 59
Total FP CONTRA 6
Total FP INCONS 52
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.144
Average MCC ± 95% Confidence Intervals 0.145 ± 1.950
Sensitivity 0.173
Positive Predictive Value 0.134
Nr of predictions 2

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.