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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of MXScarna(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & MXScarna(seed) [.zip] - may take several seconds...


Overview

Metric MaxExpect MXScarna(seed)
MCC 0.603 > 0.539
Average MCC ± 95% Confidence Intervals 0.605 ± 0.124 > 0.525 ± 0.138
Sensitivity 0.560 > 0.501
Positive Predictive Value 0.657 > 0.586
Total TP 220 > 197
Total TN 48795 > 48794
Total FP 123 < 147
Total FP CONTRA 14 < 24
Total FP INCONS 101 < 115
Total FP COMP 8 = 8
Total FN 173 < 196
P-value 3.16042554876e-08

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Performance plots


  1. Comparison of performance of MaxExpect and MXScarna(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and MXScarna(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and MXScarna(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and MXScarna(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and MXScarna(seed)).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 220
Total TN 48795
Total FP 123
Total FP CONTRA 14
Total FP INCONS 101
Total FP COMP 8
Total FN 173
Total Scores
MCC 0.603
Average MCC ± 95% Confidence Intervals 0.605 ± 0.124
Sensitivity 0.560
Positive Predictive Value 0.657
Nr of predictions 17

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00716 -0.01 0.00 0.00 0 2678 24 1 22 1 23
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.86 0.74 1.00 25 4346 1 0 0 1 9
PDB_01092 0.75 0.63 0.89 33 10116 6 0 4 2 19
RFA_00632 0.34 0.36 0.33 10 4065 20 2 18 0 18
RFA_00636 0.41 0.43 0.40 12 3975 18 2 16 0 16
RFA_00767 0.63 0.56 0.71 10 1877 4 0 4 0 8
RFA_00768 0.47 0.44 0.50 8 1875 8 1 7 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 0.63 0.56 0.71 10 2002 7 0 4 3 8
RFA_00773 0.59 0.56 0.63 10 1937 6 1 5 0 8
RFA_00779 0.61 0.56 0.67 10 1938 5 2 3 0 8
RFA_00808 0.62 0.56 0.69 9 2003 4 0 4 0 7
RFA_00809 0.37 0.38 0.38 6 2129 10 1 9 0 10

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Performance of MXScarna(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 197
Total TN 48794
Total FP 147
Total FP CONTRA 24
Total FP INCONS 115
Total FP COMP 8
Total FN 196
Total Scores
MCC 0.539
Average MCC ± 95% Confidence Intervals 0.525 ± 0.138
Sensitivity 0.501
Positive Predictive Value 0.586
Nr of predictions 17

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00716 -0.01 0.00 0.00 0 2681 21 1 19 1 23
PDB_00828 0.82 0.67 1.00 18 2467 0 0 0 0 9
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.81 0.74 0.89 25 4343 4 1 2 1 9
PDB_01092 0.70 0.63 0.79 33 10111 12 2 7 3 19
RFA_00632 0.25 0.25 0.27 7 4069 19 1 18 0 21
RFA_00636 0.35 0.36 0.36 10 3977 18 2 16 0 18
RFA_00767 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00768 0.59 0.56 0.63 10 1875 6 2 4 0 8
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.57 0.56 0.59 10 1999 7 2 5 0 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00779 0.57 0.56 0.59 10 1936 7 2 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2000 19 2 14 3 16
RFA_00809 0.30 0.31 0.29 5 2128 12 1 11 0 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.