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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & Murlet(20) [.zip] - may take several seconds...


Overview

Metric MaxExpect Murlet(20)
MCC 0.783 > 0.741
Average MCC ± 95% Confidence Intervals 0.776 ± 0.247 > 0.748 ± 0.140
Sensitivity 0.677 > 0.594
Positive Predictive Value 0.909 < 0.929
Total TP 90 > 79
Total TN 14634 < 14648
Total FP 11 > 8
Total FP CONTRA 2 > 0
Total FP INCONS 7 > 6
Total FP COMP 2 = 2
Total FN 43 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of MaxExpect and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and Murlet(20)).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 90
Total TN 14634
Total FP 11
Total FP CONTRA 2
Total FP INCONS 7
Total FP COMP 2
Total FN 43
Total Scores
MCC 0.783
Average MCC ± 95% Confidence Intervals 0.776 ± 0.247
Sensitivity 0.677
Positive Predictive Value 0.909
Nr of predictions 5

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.42 0.36 0.50 9 3303 9 2 7 0 16
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.86 0.74 1.00 25 4346 1 0 0 1 9

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 79
Total TN 14648
Total FP 8
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140
Sensitivity 0.594
Positive Predictive Value 0.929
Nr of predictions 5

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.