CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	McQFold		Vsfold4
MCC	0.594	>	0.423
Average MCC ± 95% Confidence Intervals	0.694 ± 0.092	>	0.477 ± 0.087
Sensitivity	0.583	>	0.380
Positive Predictive Value	0.611	>	0.479
Total TP	687	>	448
Total TN	158382	<	158571
Total FP	456	<	501
Total FP CONTRA	78	>	59
Total FP INCONS	359	<	428
Total FP COMP	19	>	14
Total FN	491	<	730
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of McQFold and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Vsfold4).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Vsfold4).
Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Vsfold4).

^top

Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP	687
Total TN	158382
Total FP	456
Total FP CONTRA	78
Total FP INCONS	359
Total FP COMP	19
Total FN	491

Total Scores
MCC	0.594
Average MCC ± 95% Confidence Intervals	0.694 ± 0.092
Sensitivity	0.583
Positive Predictive Value	0.611
Nr of predictions	53

^top

2. Individual counts for McQFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00018	-	0.19	0.20	0.21	4	1016	15	2	13	0	16
PDB_00020	-	0.75	0.65	0.87	13	765	2	0	2	0	7
PDB_00041	-	1.00	1.00	1.00	12	618	0	0	0	0	0
PDB_00053	-	1.00	1.00	1.00	11	424	0	0	0	0	0
PDB_00056	-	0.93	0.88	1.00	14	616	0	0	0	0	2
PDB_00123	-	0.33	0.33	0.33	12	4150	24	0	24	0	24
PDB_00124	-	0.86	0.90	0.82	9	485	2	2	0	0	1
PDB_00128	-	0.80	0.71	0.91	10	485	1	0	1	0	4
PDB_00134	-	0.79	0.63	1.00	5	373	0	0	0	0	3
PDB_00138	-	0.94	1.00	0.89	8	369	1	1	0	0	0
PDB_00209	-	0.96	1.00	0.92	11	549	1	1	0	0	0
PDB_00243	-	1.00	1.00	1.00	12	618	0	0	0	0	0
PDB_00352	-	0.86	0.79	0.94	15	1209	1	0	1	0	4
PDB_00370	-	0.00	0.00	0.00	0	15181	44	13	31	0	25
PDB_00447	-	0.11	0.11	0.12	5	7097	38	7	31	0	39
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00713	-	0.43	0.43	0.45	9	1996	11	0	11	0	12
PDB_00716	HDV_ribozyme links to Rfam database...	0.68	0.70	0.67	16	2677	9	0	8	1	7
PDB_00804	-	0.00	0.00	0.00	0	15344	56	10	46	0	50
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_00842	-	0.79	0.63	1.00	5	373	0	0	0	0	3
PDB_00851	-	0.49	0.44	0.56	18	4721	14	0	14	0	23
PDB_00857	-	1.00	1.00	1.00	15	1066	0	0	0	0	0
PDB_00874	-	-0.02	0.00	0.00	0	928	18	0	18	0	20
PDB_00886	-	-0.01	0.00	0.00	0	4147	39	0	39	0	40
PDB_00918	-	0.93	1.00	0.88	7	317	1	1	0	0	0
PDB_01009	tRNA links to Rfam database...	0.90	0.90	0.90	19	2464	5	0	2	3	2
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01040	-	0.30	0.30	0.32	6	1109	13	0	13	0	14
PDB_01059	-	0.88	1.00	0.78	7	222	2	2	0	0	0
PDB_01070	-	0.78	0.70	0.86	38	12676	6	0	6	0	16
PDB_01073	SAM links to Rfam database...	0.52	0.47	0.57	16	4343	13	2	10	1	18
PDB_01092	glmS links to Rfam database...	0.81	0.75	0.89	39	10109	6	1	4	1	13
PDB_01194	-	0.89	0.87	0.93	13	482	1	1	0	0	2
PDB_01201	-	0.88	0.77	1.00	17	1111	0	0	0	0	5
PDB_01203	-	0.74	0.68	0.81	13	1160	3	2	1	0	6
PDB_01250	-	0.17	0.15	0.19	6	12059	25	5	20	0	35
PDB_01260	-	0.92	0.92	0.92	23	1805	2	1	1	0	2
PDB_01281	-	-0.04	0.00	0.00	0	365	13	0	13	0	14
PDB_01299	-	0.71	0.67	0.77	10	890	3	1	2	0	5
PDB_01309	-	0.12	0.15	0.10	6	9122	56	12	40	4	33
RFA_00632	HDV_ribozyme links to Rfam database...	0.88	0.89	0.86	25	4066	4	3	1	0	3
RFA_00636	HDV_ribozyme links to Rfam database...	0.73	0.71	0.74	20	3978	7	5	2	0	8
RFA_00767	Corona_pk3 links to Rfam database...	1.00	1.00	1.00	18	1873	0	0	0	0	0
RFA_00768	Corona_pk3 links to Rfam database...	1.00	1.00	1.00	18	1873	0	0	0	0	0
RFA_00769	Corona_pk3 links to Rfam database...	0.85	0.94	0.77	17	1931	5	4	1	0	1
RFA_00770	Corona_pk3 links to Rfam database...	0.88	0.78	1.00	14	2002	4	0	0	4	4
RFA_00773	Corona_pk3 links to Rfam database...	0.97	1.00	0.95	18	1934	5	1	0	4	0
RFA_00779	Corona_pk3 links to Rfam database...	0.97	0.94	1.00	17	1936	0	0	0	0	1
RFA_00808	RydC links to Rfam database...	1.00	1.00	1.00	16	2000	0	0	0	0	0
RFA_00809	RydC links to Rfam database...	0.79	0.81	0.76	13	2128	4	0	4	0	3

^top

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	448
Total TN	158571
Total FP	501
Total FP CONTRA	59
Total FP INCONS	428
Total FP COMP	14
Total FN	730

Total Scores
MCC	0.423
Average MCC ± 95% Confidence Intervals	0.477 ± 0.087
Sensitivity	0.380
Positive Predictive Value	0.479
Nr of predictions	53

^top

2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.84	0.71	1.00	10	936	0	0	0	0	4
PDB_00018	-	0.20	0.20	0.22	4	1017	14	2	12	0	16
PDB_00020	-	0.46	0.35	0.64	7	769	4	0	4	0	13
PDB_00041	-	0.70	0.50	1.00	6	624	0	0	0	0	6
PDB_00053	-	0.73	0.55	1.00	6	429	0	0	0	0	5
PDB_00056	-	-0.02	0.00	0.00	0	618	12	0	12	0	16
PDB_00123	-	0.35	0.33	0.38	12	4154	20	0	20	0	24
PDB_00124	-	0.59	0.50	0.71	5	489	2	0	2	0	5
PDB_00128	-	0.17	0.14	0.25	2	488	6	1	5	0	12
PDB_00134	-	0.79	0.63	1.00	5	373	0	0	0	0	3
PDB_00138	-	0.79	0.63	1.00	5	373	0	0	0	0	3
PDB_00209	-	0.56	0.45	0.71	5	554	2	0	2	0	6
PDB_00243	-	0.76	0.58	1.00	7	623	0	0	0	0	5
PDB_00352	-	0.89	0.79	1.00	15	1210	0	0	0	0	4
PDB_00370	-	0.00	0.00	0.00	0	15188	37	15	22	0	25
PDB_00447	-	0.28	0.23	0.34	10	7111	19	2	17	0	34
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00713	-	0.47	0.43	0.53	9	1999	8	0	8	0	12
PDB_00716	HDV_ribozyme links to Rfam database...	0.17	0.17	0.18	4	2679	19	0	18	1	19
PDB_00804	-	0.41	0.38	0.45	19	15358	25	0	23	2	31
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_00842	-	0.79	0.63	1.00	5	373	0	0	0	0	3
PDB_00851	-	0.56	0.44	0.72	18	4728	7	0	7	0	23
PDB_00857	-	0.77	0.60	1.00	9	1072	0	0	0	0	6
PDB_00874	-	-0.01	0.00	0.00	0	936	10	0	10	0	20
PDB_00886	-	-0.01	0.00	0.00	0	4152	34	0	34	0	40
PDB_00918	-	0.75	0.57	1.00	4	321	0	0	0	0	3
PDB_01009	tRNA links to Rfam database...	0.90	0.90	0.90	19	2464	3	0	2	1	2
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01040	-	0.30	0.30	0.33	6	1110	12	0	12	0	14
PDB_01059	-	0.65	0.43	1.00	3	228	0	0	0	0	4
PDB_01070	-	0.43	0.37	0.50	20	12680	20	0	20	0	34
PDB_01073	SAM links to Rfam database...	0.55	0.47	0.64	16	4346	10	0	9	1	18
PDB_01092	glmS links to Rfam database...	0.66	0.58	0.77	30	10114	10	2	7	1	22
PDB_01194	-	0.44	0.33	0.63	5	488	3	1	2	0	10
PDB_01201	-	0.79	0.64	1.00	14	1114	0	0	0	0	8
PDB_01203	-	0.73	0.63	0.86	12	1162	2	2	0	0	7
PDB_01250	-	0.00	0.00	0.00	0	12061	32	1	28	3	41
PDB_01260	-	0.58	0.44	0.79	11	1816	3	0	3	0	14
PDB_01281	-	-0.03	0.00	0.00	0	366	12	0	12	0	14
PDB_01299	-	0.74	0.67	0.83	10	891	2	1	1	0	5
PDB_01309	-	-0.01	0.00	0.00	0	9124	56	12	44	0	39
RFA_00632	HDV_ribozyme links to Rfam database...	0.36	0.36	0.37	10	4068	17	3	14	0	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.58	0.57	0.59	16	3978	11	1	10	0	12
RFA_00767	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1878	13	1	12	0	18
RFA_00768	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1875	16	1	15	0	18
RFA_00769	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	4	5	0	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	2003	15	2	11	2	18
RFA_00773	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1936	19	1	16	2	18
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	2	1	0	8
RFA_00808	RydC links to Rfam database...	0.62	0.56	0.69	9	2003	4	3	1	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

2. Individual counts for McQFold [ download as .csv ]

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]